Honest Nutrition

Is Resveratrol stable after exposure to air?

2012-01-13T11:16:00.000-06:00

The question of whether the polyphenol Resveratrol will readily oxidize when exposed to air has been addressed scientifically. At the time of this relevant study (Prokop J, Abrman P, Seligson AL, Sovak M. Resveratrol and its glycon piceid are stable polyphenols. J Med Food. 2006 Spring;9(1):11-4. PubMed PMID: 16579722.), there were no published studies suggesting that Resveratrol was unstable, despite contrary claims being made by some. This study solidly confirmed Resveratrol's long-term stability under ambient handling and storage conditions for at least 4 years, as well as being stable for years even under more extreme "accelerated" storage conditions.

I can confidently report at this time that Resveratrol does not deteriorate when exposed to air and therefore does not require any special manufacturing processes that exclude oxygen. This has been confirmed by both this independent study published in a peer-reviewed journal and by stability studies performed on Resveratrol finished products by qualified scientists. Despite the assertion that Resveratrol requires special handling in oxygen-free conditions, we have seen no published data to support that claim.

Antioxidants misunderstood

2011-10-25T15:42:00.001-05:00

In “Radical thinking on antioxidants” (Chicago Tribune, Oct. 6) there is a useful discussion of the controversial role of antioxidant nutrients in our health. While much of the information presented was fair, there were omissions and inaccurate statements made that should be addressed.

To understand the controversy over antioxidant nutrition, it is important to remember that this particular class of nutrients consists of individual substances that, unlike drugs, do not operate independently in the body. The failure to respect that fact has caused many researchers, especially those assembling and publishing statistical models of supposedly similar already-published studies, to veer way off course from reality. The most common errors include the use of the so called “gold standard” model used for pharmaceutical studies that looks at the intake of an individual substance and is randomized, double-blinded, and placebo controlled. But that model often fails to produce meaningful or consistent results when antioxidant nutrients are involved. Why?

One big problem is that antioxidants are synergistic and depend on one another to survive in a healthy state. A classic example is vitamin C, with a half-life of about 30 minutes. We would all die of scurvy in a few hours if we didn’t have a mechanism for recycling and recharging that spent antioxidant vitamin. That mechanism is antioxidant synergy, where other antioxidants recharge the spent ones so they can continue their essential work in our bodies. Antioxidants that have used one of their electrons to stop a dangerous chain reaction of free radicals ripping electrons from healthy cells –an otherwise uncontrolled electrical spark - can themselves become a problem if they over-accumulate, which is a signal that we lack other types of antioxidants that could restore their antioxidant potential.

Another problem is the tendency of supplement critics to exaggerate their opinions. In this article, a cardiologist reportedly claimed that, “there is little to no data supporting the use of antioxidants to protect against disease.” That can be easily disproven by a cursory look at medical journals. For example, the American Journal of Cardiology reported evidence that “coenzyme Q10 supplementation may decrease muscle pain associated with statin treatment... supplementation may offer an alternative to stopping treatment with these vital drugs.” Another issue of that journal noted that “coenzyme Q10 supplementation in patients with worsening diastolic function with statin therapy improved parameters of diastolic function.” And the Journal of the American College of Cardiology published a referenced Expert Consensus Document that listed evidence for cardiovascular health benefits of antioxidants CoQ10, hawthorn extract, and ginkgo leaf extract.

http://articles.chicagotribune.com/2011-10-06/health/ct-met-antioxidants-20111006_1_antioxidants-dietary-supplements-free-radicals

Perimenopause/Menopause Interview notes

2011-08-30T16:03:00.000-05:00

Perimenopause is the time period where the body’s hormone balance is changing; menopause actually marks the one-year anniversary of the cessation of menstrual cycles (menstruation). Most menopause formulas are actually targeted at perimenopause symptoms.

The recent clinical evidence for, and availability of, products that don’t contain soy, isoflavones, or phytoestrogens should greatly help those who won’t or can’t use products containing those components. This now opens the perimenopause category to those who were previously shut out.

This is a strong category but with a lot of competition among products and claims that inevitably leads to some confusion; not only among consumers but for some store personnel, as well. Product information from manufacturers can either clarify or confuse, depending on the message that they’re trying to send: are they trying to tout their own product as better than everyone else’s, or are they accurately representing the science and trying to provide real consumer choice?

Vitex (Vitex agnus castus), or chaste tree berry, contains small amounts of Agnusides, the active component of chaste berry. Chaste berry extract has been researched to corroborate traditional usage for supporting healthy female hormonal levels during menopause.

Dong Quai (Angelica sinensis) root is a traditional herb for female hormonal support, but has not been historically used for perimenopause/menopause.

Ipriflavone (7-isopropoxy-isoflavone) is a natural-identical soy-free isoflavone (bioflavonoid) that supports bone health, helps maintain healthy bone density, and supports post-menopausal calcium metabolism.

Natural Progesterone Skin Cream typically provides 20 mg of Natural Progesterone USP per use. Look for products with no artificial colors or fragrances that are paraben-free. Synthetic progesterone is not nature-identical.

Black Cohosh (Cimicifuga racemosa) is an herb that has been traditionally used by Native Americans to alleviate the symptoms of menopause and other female complaints.

Red Clover (Trifolium pratense) is an herb particularly rich in biologically active compounds called phytoestrogens that are recognized for their role in the support of healthy estrogen levels.

Soy Isoflavones are naturally occurring phytoestrogen plant compounds (Genistein, Daidzein and Glycitein) that are particularly concentrated in soybeans and which support high or low estrogen levels.

Pharmaceutical Drugs, including synthetic forms of female hormones, have side effects that may contraindicate their use since they are isolated synthetic substances, so many women prefer to avoid them. Since the normal change of life is not a disease state, the use of traditional natural substances to manage health makes sense to most people.

Women need to carefully review any label cautions and interactions, as well as the usage suggestions, to avoid any known interactions with medications. Even if no interactions have been noted, caution should be used when adding any new substance, however natural, to a medication regime.

People often mistakenly think that all estrogen compounds are alike. However, phytoestrogens are plant-based food compounds found in virtually all legumes that are about 1,000 times weaker than the usual circulating body-produced estrogen forms. That difference and the source makes plant estrogens much safer. Even soy isoflavones, which are phytoestrogens, have some key differences from endogenous estrogens formed in the body: much like cruciferous vegetables, soy isoflavones may actually prevent the conversion of estrogens into harmful forms (like 16α-hydroxyestrone), promote their breakdown by Phase II detoxification, and increase their excretion in the urine.

Another myth is that symptoms of perimenopause can all be treated the same. Everyone’s hormone levels are unique and complicated, so not every product will work for every person. Some trial and error may be required, and some consumers elect to have their hormone levels checked to help them choose which products are most likely to be right for them.

Fish Oil: Excerpts from a magazine interview with me

2011-08-24T13:16:00.000-05:00

The balance of fatty acids in the body can promote inflammatory or non-inflammatory states. Higher amounts of omega-3 fats in the diet have been shown to modulate inflammation and keep it within healthy ranges. The various cellular and tissue damage that can occur from chronic inflammatory states are certainly not healthful. This basic mechanism of action implies a wide-ranging and powerful effect of omega-3 fats to support wellness. Additionally, these fats are part of brain and nerve structures, so they help to maintain the health of those tissues, as well.

Omega-3 and omega-6 fats have been called “essential fatty acids” since the body can’t manufacture them from other fats, as it typically can for other types of fat. The optimal ratio of omega-6 to omega-3 fats is somewhere between 1:1 and 3:1. The common American diet has been estimated to be over 15:1, a marked deviation from a healthy norm.

The benefits of most other non-omega-3 fatty acids in fish oil are not well-defined in the scientific literature. Fish oil naturally contains a range of fats, including cholesterol, triglycerides, and stearic acid. The ones that are considered less desirable, cholesterol and triglycerides, are sometimes removed from fish oils to further concentrate the omega-3 portion and allow higher strengths in fewer capsules.

All natural oils contain various mixtures of fatty acids in varying amounts. Omega-9 fats are best known as being abundant in Olive Oil, and are considered non-inflammatory and especially healthy if substituted for most omega-6 fats that are pro-inflammatory. Some natural oils are fairly well balanced, such as flax and hemp seed oils, or walnut oil. Others, like fish oil, tend to be predominantly omega-3. Most vegetable oils are mostly omega-6 fats and their predominance in the modern diet has been blamed for some of our poor health.

Some consumers do know about various sources of fish oil, and some have advantages or disadvantages. For example salmon is a favored source of omega-3 fats, though salmon oil typically contains less than other common fish oils. Traditional fish sources may be better accepted by those who won’t or can’t eat shellfish. The fisheries in Norway and Peru are among the best managed traditional fisheries on earth.

Krill, a small crustacean shellfish, is a unique source of omega-3 fats since krill also naturally bonds the fatty acids to phospholipids, which are essential for cell membranes and which enhance the bioavailability of the oil. Krill oil also contains the powerful antioxidant pigment astaxanthin, which is responsible for the color of shrimp and salmon. Krill is considered the best managed fishery in the world, with trained observers on each boat monitoring the harvest. The krill harvest limit can be rapidly adjusted to support a healthy population, and the total world harvest (most of which goes into pet foods) is only a fraction of the allowable sustainable harvest level.

Thyroid supplements

2011-08-01T22:31:00.000-05:00

People typically seek thyroid support nutrients as a way to enhance their energy levels, enable proper control of their body temperature, and support a strong metabolic rate. We take these nutrients, both individually and in formulas, in order to assure adequate levels to support optimal thyroid function, since a deficiency or insufficiency of key nutrients could reduce the operational efficiency of the thyroid gland. Proper thyroid function supports a lean body composition and helps prevent fatigue. Under the control of complex feedback and signals from the hypothalamic-pituitary-thyroid axis, the thyroid gland regulates body temperature and metabolism rates, playing an important role in weight management and energy states. By the same token, if any of the important nutrients are not available to the thyroid in sufficient amounts, metabolic rates and energy levels could suffer. ¹

Natural thyroid support supplements work primarily by providing precursors of thyroid hormones, along with various cofactors, in order to encourage proper thyroid function. In some cases, the lack of adequate nutritional resources prevent the thyroid gland from maintaining optimal efficiencies, and if the gland can’t maintain healthy levels of its important hormones, then it can’t adequately support the body’s metabolism. Unlike medical treatments, nutritional approaches focus on providing what the body needs in order to assure that the thyroid has its particular needs met and can function optimally.

The key nutrients for thyroid function are the mineral Iodine and the natural amino acid L-Tyrosine.

Humans require iodine for cellular metabolism and for normal thyroid function; specifically for the production of thyroid hormones. Thyroid hormones regulate many important biochemical reactions, including protein synthesis and enzymatic activity, and are critical determinants of metabolic activity. Iodine is a nutrient that can sometimes be obtained from the soil, but many soils are deficient. Areas that are mountainous, very rainy, or prone to floods/erosion tend to have soils that are low in iodine, increasing the risk that foods grown in those areas will be iodine-deficient. Table salt is commonly iodized, but those using non-iodized salt or on low-sodium diets can’t rely on that source. Multivitamin formulas, thyroid support formulas, kelp and some other seaweeds, and some multimineral formulas provide supplemental iodine. The U.S. Recommended Dietary Allowance (RDA) is 150 mcg (micrograms) daily for adults ages 18 and older, 220 mcg daily for pregnant women, and 290 mcg daily for lactating women. The Tolerable Upper Intake Levels (UL) for adults ages 18 and older is 1,100 micrograms daily. ^2-3 ^]

The common sources of iodine in dietary supplements include Potassium Iodide, Kelp, and other seaweeds. While kelp and some seaweeds are fine for getting the relatively low RDA level of iodine intake, those seeking much higher levels are usually advised to consider Potassium Iodide. This is because seaweeds typically contain less than 1% iodine, along with a lot of other metals and minerals - including some that we may want to avoid getting too much of - so consuming high doses of seaweeds on a daily basis may not be our safest option. And iodine is a mineral nutrient that needs to be replenished daily.

L-Tyrosine is an amino acid that is important to the structure of most proteins in the body. It is also the precursor of a number of neurotransmitters and hormones, including the major catecholamines dopamine, norepinephrine, and epinephrine (adrenaline), which are stress hormones made by the adrenal glands. In addition to these functions, tyrosine also helps produce melanin (the pigment responsible for hair and skin color) and helps in the function of the adrenal, thyroid, and pituitary glands. Because of these varied responsibilities and the ability of various stresses and dietary deficiencies to reduce tyrosine levels, people sometimes supplement tyrosine (as natural L-Tyrosine) in order to support proper thyroid function. ^4-5

How do Iodine and L-Tyrosine affect thyroid function? The thyroid gland’s epithelial cells prepare large quantities of tyrosine into a glycoprotein “scaffold” that is the structural backbone used to form the thyroid hormones thyroxine (T4) and triiodothyronine (T3). The scaffold and iodine are both secreted into the lumen of the thyroid gland, where an enzyme facilitates the hormone synthesis. Other enzymes then separate the hormones from the scaffolding in steps, liberating them into their circulating forms. A few tyrosines are incorporated into these hormones, but most are left in the scaffolding structure’s remains that will be recycled by the body.

Selenium is an essential mineral nutrient that is necessary for normal thyroid hormone metabolism. Selenium-containing enzymes control the synthesis and degradation of the biologically active thyroid hormone, T3. Selenium deficiency may worsen the effects of iodine deficiency on thyroid function, and adequate selenium nutritional status may help protect against some of the neurological effects of iodine deficiency. Additionally, selenium-based antioxidant enzymes protect the thyroid gland from peroxides produced during the synthesis of these hormones. ^{2, 3, 6}

Zinc, another essential mineral responsible for hundreds of critical chemical reactions in the healthy human, is also important for maintaining normal thyroid homeostasis. Its complex roles include effects on both the synthesis and mode of action of the hormones. Thyroid hormone binding transcription factors, which are essential for modulating gene expression, contain zinc bound to cysteine-related compounds. In some studies, low zinc status was associated with decreased thyroid hormone levels. ³

Copper is believed to have a role in thyroid hormone function, perhaps related to selenium status. ³

Guggul (Commiphora mukul) is an Indian Ayurvedic herb that contains the active compound Guggulsterone, which has been shown to stimulate thyroid activity. ^7-8

These ingredients, both singly and as thyroid support formulas, are in demand by consumers wanting to assure adequate thyroid function in times of dietary insufficiencies and various stresses. Of course, these nutrients and their many functions in the body have a host of potential benefits to those supplementing with them if they may not get adequate amounts from their diet for their individual requirements.

REFERENCES

Zoeller RT, Tan SW, Tyl RW. General background on the hypothalamic-pituitary-thyroid (HPT) axis. Crit Rev Toxicol. 2007 Jan-Feb;37(1-2):11-53. Review. PubMed PMID: 17364704.
http://ods.od.nih.gov/factsheets/Iodine-HealthProfessional/
Arthur JR, Beckett GJ. Thyroid function. Br Med Bull. 1999;55(3):658-68. Review. PubMed PMID: 10746354.
http://www.umm.edu/altmed/articles/tyrosine-000329.htm
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/thyroid/synthesis.html
http://ods.od.nih.gov/factsheets/selenium/
http://www.drugs.com/npp/guggul.html
http://www.peoplespharmacy.com/2005/10/18/guggul/

NYT Hatchet Job on Senator Hatch

2011-07-06T22:48:00.000-05:00

Re: “Support Is Mutual for Senator and Utah Industry” (The Champions, June 20, New York Times)

The article presented an inaccurate impression regarding the nutritional supplement industry. Despite heavy costs, manufacturers supported federal regulations creating more rules/enforcement to enhance accountability and public safety. A 1994 law (DSHEA) regulating the dietary supplement industry allows only FDA-approved ingredients and scientifically-supported claims relating to healthy body structures and functions; besides FDA-approved claims.

Additional regulations supported by industry: DSHEA’s mandatory Good Manufacturing Practices (GMP) requiring safety and identity testing, steroids and their precursors are banned; manufacturers must promptly disclose adverse events requiring medical attention; mandatory safety recall authority.

Senator McCain’s proposed dietary supplement regulation would have subjected each new product introduction to prior FDA approval, expanding the federal bureaucracy with a government takeover of the industry. Importing this Canadian-style regulatory scheme would duplicate that system’s failures: half as many products available; some considered safe in the USA are banned; long waits for variations of existing products; higher prices.

Fortunately, the American people rejected giving government bureaucrats veto authority over all new nutritional products, which already must use preapproved ingredients. We view this as anti-capitalism and un-American.

Neil E. Levin, CCN, DANLA

Clinical Nutritionist

HonestNutrition.com

re:

http://www.nytimes.com/2011/06/21/us/politics/21hatch.html?_r=2&pagewanted=all

My Interview on Memory and Brain Health for a trade magazine

2011-06-15T17:29:00.001-05:00

The brain must be intact and healthy in order for it to perform normal functions like thought and memory. There is evidence that chronic or acute inflammation, or other insults to brain cells/tissues from chemicals or other damaging agents, can provoke negative health effects. In essence, the brain is literally under attack on a daily basis, requiring a constant infusion of supporting protective nutrients to maintain proper brain health and functionality.

Antioxidants and magnesium are key nutrients needed to protect the brain from chemicals called excitotoxins, such as MSG, which are damaging to brain cells when levels of various nutrients are insufficient to control them. The physical damage to brain cells that can be caused by oxidation, sometimes in the form of a bio-electrical spark causing a chain reaction that rips electrons from a string of innocent cells until an antioxidant ‘electron donor’ puts an end to it, can be prevented or stopped by antioxidants. Antioxidants also protect fats from oxidizing (going rancid), and since the brain is nearly half fat it is dependent on both fatty acids and antioxidants to protect its structural integrity.

While it is normally not necessary to see a physician before taking a brain/memory support dietary supplement, people on medications should always check if there are known interactions before using any new supplement and it is wise to always bring a list of your supplements to share with your doctor at your annual check-up. Those with known memory problems should request a medical evaluation to set a baseline level in order to maintain their mental assets and be able to compare future mental performance.

To aid this preservation of our mental faculties, it is obviously best to consume adequate levels of relevant protective nutrients for many years, rather than waiting until the senility of old age creeps up on us and then trying to regain lost abilities. Otherwise, careful eating and appropriate supplementation may be started ‘too little, too late.’

The best mental/brain support nutrients include some surprisingly ordinary ingredients: Lecithin, Vitamins A-E, and Antioxidants. Lecithin provides essential phospholipids for the brain, nerves, and cell membranes; including Choline, Serine, and other brain nutrients that directly support neurotransmitter production and memory. Lecithin’s Phosphatidyl Choline (PC) is a precursor of the neurotransmitter acetylcholine; in the central nervous system acetylcholine is involved in learning, memory, and mood. Phosphatidylserine (PS) also affects the levels of neurotransmitters in the brain related to mood, memory, and mental function.

Lecithin, which is a highly processed extract of soybean oil, does not in itself contain protein (allergens) or genetic material (GMOs), which the original soybeans may have contained. Some Lecithin products are derived from certified non-GMO soybeans or even sunflower seeds.

Another way to get Lecithin’s benefits is in the form of Krill Oil. Krill has its Omega-3 fatty acids bonded to phospholipids similar to those found in soy or egg lecithin. So krill not only supplies EPA, DHA, and phospholipids for brain, nerve, and membrane health but also enhances their bioavailability and access to the brain due to the ability of phospholipids to cross the blood-brain barrier better than ordinary fish oils. Fish Oils providing EPA and DHA should also be considered brain nutrients, as DHA is a significant physical component of the brain.

Vitamin E and its related compounds (the tocotrienols) have been shown to protect neurons (brain and nerve cells) from being damaged or even killed off by excitotoxic chemicals. The antioxidant benefits of this essential vitamin’s “family” of compounds also help to prevent oxidative reactions that can damage brain tissues. Look for gamma-tocopherol along with the usual alpha-tocopherol plus higher amounts of gamma- and delta- form tocotrienols.

Vitamin C directly pumps excitotoxins from neurons, protecting the brain and nerve cells from being damaged by these potentially toxic chemicals. There are several populations with impaired ascorbate absorption; including those with poor insulin sensitivity, those with gut inflammation, those who take aspirin, and those on low sodium diets; all situations where normal vitamin C uptake and utilization is often suboptimal.

Other antioxidants of benefit for brain health include Alpha Lipoic Acid, various carotenoids including Astaxanthin (also found in Krill oil), and Pycnogenol®. In addition to supplementation, it always helps to consume a variety of antioxidants from fruits and vegetables to maintain a good level and balance of antioxidants.

The formation of abnormal structures in the brain may in part be due to oxidative damage that perhaps can be kept within normal acceptable ranges by having a variety of antioxidant nutrients available. Genes in the subject cells are controlled by “switches,” that are in turn modulated by environmental “triggers.” The presence of various protective nutrients helps to maintain proper cellular health; whereas the deficiency of adequate protective nutrients can allow potentially damaging effects, leading to cell death and the subsequent formation of abnormal brain structures.

The presence of excessive amounts of saturated fats in the diet, especially if from an excess of processed foods, inevitably reduces the amount of available long-chain fatty acids EPA and DHA (DHA can be made from EPA) that are essential for brain and nerve health. The deficit of these two fatty acids increases the likelihood of uncontrolled inflammatory processes in the body, as an imbalance of beneficial dietary fats like EPA, DHA and GLA that can reduce the fatty acids needed to make prostaglandins responsible for maintaining a healthy inflammatory response. The fact that EPA is needed for healthy membranes throughout the body and DHA is an important constituent of the brain itself also testify to the importance of these fatty acids for healthy brain structures and functions, including memory.

• Natural antioxidant vitamins Beta-Carotene, C, and E are protective of brain tissues and are available in antioxidant formulas and multiple vitamins..

• Alpha GPC is a form of choline that is bioavailable to the brain; an acetylcholine precursor, it supports memory and cognitive acuity.

• DMAE is a naturally occurring amino metabolite known primarily as a precursor to choline and acetylcholine, chemicals in the brain responsible for nerve transmissions and cognitive function; DMAE has been used most predominantly to improve memory and focus while stimulating neural activity.

• NADH is a metabolite of niacin (vitamin B3) that is directly involved in neurotransmitter production to support mental alertness.

• Ginkgo biloba extract is thought to improve memory and quality of life, and is available in various strengths.

• Acetyl-L-Carnitine is a form of an important amino acid, which in short-term studies has improved memory in older adults.

• Vitamin B1 deficiencies have been associated with confusion and memory loss in seniors deficient in that nutrient.

• High strength fish oils and Krill oil supply the omega-3 fatty acids DHA and EPA that are important brain and nerve components often deficient in the general population.

• Genistein, a phytoestrogen found in Soy Protein Isolates and Soy Isoflavones, has been shown to act as an antioxidant to preserve brain cell integrity.

• Ashwagandha has been shown to be protective of brain cells in non-clinical laboratory experiments.

Prenatal vitamins lower autism risk in children

2011-06-10T17:18:00.001-05:00

Taking prenatal vitamins lowers the risk of having an autistic child by 700% for genetically susceptible mothers. http://www.sciencedaily.com/releases/2011/05/110525112109.htm

Essential Oil Quality and Grades

2011-05-21T22:40:00.000-05:00

Essential oils are by definition produced in one of two ways:

Steam distillation (most herbs)
Cold pressing (citrus and a few herbs)

These two methods produce a single grade of oil called an essential oil. If produced by solvent extraction, a different term is used, such as absolute oil or extract.

Different brands of essential oils made from the same species of plant made appropriately by either of the two methods listed above are by definition the same grade. Of course, like any botanical, the sensory qualities but not the basic chemistry of a species can change a bit depending on where it's grown, just as olives and grapes do, without affecting quality or grade.

There are three basic analytical tests to determine quality and identity of essential oils:

Sensory testing performed by trained testers
Infrared spectrum analysis (IR) that produces a chemical fingerprint of the oil
Gas chromatography (GC) that produces a separation and quantification of individual chemical components in the oil

These techniques are used with all samples having to match strict specifications, official standards and reference samples to pass quality control before they can be sold by manufacturers following strict quality procedures. Reputable reference works used by oil chemists, such as the Guenther series, guide the testing.

If the original plant is edible then the essential oil is by definition food grade. Some examples are the citrus oils, peppermint, oregano, etc. If the plant is not edible then the oil is also not considered food grade; as with cedarwood, pennyroyal, or ylang ylang. Due to the small bottle size and the need for cautions, there is not typically a food label on these oils.

Much caution needs to be taken with these oils, as they are extremely concentrated and most can burn the skin and mouth if not diluted adequately, even if food grade. Don't swig them or apply undiluted to the skin if you don't know how to use the specific type of oil in question.

Neil gives keynote presentation at conference in Beijing

2011-05-21T22:11:00.000-05:00

I gave a presentation on "Health Benefits of Wholegrain Diets" April 20th in Beijing: This 2-day Whole Grain Forum was part of the Third International Nutrition & Healthy Industry Expo organized by the Center for Public Nutrition and Development of China (PNDC) of the National Development and Reform Commission (NDRC), along with US-based Grains for Health Fdtn and Whole Grains Council.

http://www.facebook.com/l.php?u=http%3A%2F%2Fwww.pndc.gov.cn%2Fexpo%2Fenglish%2Fabout.html&h=28a7b

Functional Doses of Vitamins and Minerals for Bones

2011-04-26T11:02:00.000-05:00

• Protein: 0.8 grams per kilogram of body weight

• Calcium: Over 1 gram per day

• Magnesium: 310 – 420 mg per day

• Zinc: 15 mg per day

• Copper: 2.5 to 3 mg per day

• Boron: 3 mg per day

• Manganese: 5 mg per day

• Potassium: 3,500 to 4,000 mg per day

• Vitamin D: over 500 IU daily

• Vitamin K: Levels are not well understood; at least 90 mcg/d for women and 120 mcg/d for men

• Vitamin C: over 500 mg daily

• Vitamin A: 2333 IU in women and 3000 IU in men; avoid low and excessive amounts

Palacios C. The role of nutrients in bone health, from A to Z. Crit Rev Food Sci Nutr. 2006;46(8):621-8. Review. PubMed PMID: 17092827.

Sleep-Stress Interview, Natural Products Marketplace magazine

2011-03-22T15:49:00.000-05:00

Everyone living in our modern world experiences stress, and if our ability to adequately control it diminishes so does our ability to get a good night’s sleep. Sleep time allows repair and recovery to occur, both mental and physical. The inability to recover from chronic stress can increase stress-related eating habits with a subsequent accumulation of abdominal fat on the one hand, and lead to physical and emotional exhaustion on the other. In fact, the deprivation of sound sleep is a common complaint that is associated with a lack of energy. Energy deficits can lead to a diminished immune response. So we see a host of common complaints that can be at least partially attributed to a lack of sleep and the causes thereof.

The lack of a good night’s sleep can be related to a lack of melatonin; a natural hormone made from the amino acid l-tryptophan and its metabolite 5-HTP. Melatonin is formed from serotonin, a metabolite of 5-HTP that is made in the pineal gland during darkness…this means that falling asleep in a bright room, or in front of the TV, may leave one less than fully engaged in sleep and its several stages of healthy brain waves that allow true relaxation to occur. Melatonin is also an antagonist of the aforementioned stress hormone cortisol, and so adequate darkness/sleep/melatonin production is a key factor in controlling chronic stress and its negative effects on the body.

The adrenal glands help the body respond and adjust to stress generated from both internal and external forces. Under chronic stress, cortisol can be overproduced, resulting in weight gain and difficulty in managing healthy blood sugar levels. Adaptogenic herbs help the body to manage the negative effects of stress, such as excess abdominal fat deposition, overeating, and low energy levels.

We see specific sleep solutions that are targeted to enhance certain normal mechanisms; for example, to reduce cortisol and/or increase melatonin to maintain them within healthy levels. Another strategy is to add certain amino acids that are precursors of relaxing or inhibitory neurotransmitters. And some people prefer to utilize individual herbs, while others prefer to take a formula combining multiple mechanisms.

Kava Kava helps people to relax but does not act as a strong sedative. Kava has been used by people to stay calm before taking a test and may support mental focus and calmness.

The essential mineral Magnesium has long been used, sometimes with Calcium, to relax muscles. Magnesium also has an effect to relax overstimulated brain neurons by acting against those excitotoxic states.

L-Theanine is an amino acid found commonly in green tea. L-Theanine promotes relaxation without the drowsiness or negative side effects associated with some other calming agents. L-Theanine also supports healthy cardiovascular function through this relaxing effect, as well as its antioxidant properties.

L-Tryptophan and 5-HTP products are available in various strengths; make sure that the one you buy has been safety, identity, and potency tested. These amino acids are precursors of the important neurotransmitter serotonin, as well as its metabolite melatonin. Melatonin is used by the body to regulate sleep cycles, as an antioxidant, and as an anti-stress aid; in addition to other wide-ranging health effects on the human body.

Relora® is an all-natural proprietary blend of plant extracts from Magnolia officinalis and Phellodendron amurense herbs that helps to control cortisol. Relora® is a safe, non-sedating formula that can help to alleviate symptoms associated with stress such as nervous tension, irritability, concentration difficulties and occasional sleeplessness. The relaxing effect of Relora® can thereby help to control appetite and prevent stress-related eating, aiding in weight control.

100% pure Essential Oils have long been used for aromatherapy, including some oils known to be relaxing. Whether using these oils to sniff, use with reed or other diffusers, blending into carrier oils (almond, olive, apricot kernel, etc.) for massage, or adding a few drops to bath water or potpourri, many people find some of these powerful oils to be very relaxing. Lavender, Chamomile, Marjoram, and Germanium Oils are especially soothing and relaxing.

Some supplements are safe to take daily; for example, the gentler stress vitamins, Chamomile tea, essential oils used in aromatherapy. It is best to be more cautious with stronger herbal and amino formulas, though there’s no strict rule of thumb on how long to take them. Chronic stress may need to be dealt with for many months, resisting a quick fix. On the other hand, one can often cut the melatonin dose down after a month or two of resetting the sleep cycle.

People may not sleep due to a number of factors, and their individual stressors makes it more difficult to figure out which products may help them to normalize their sleep and minimize their stress. Matching the person to the solution is always the biggest challenge, and some trial and error may need to be factored in before a solution is found.

For some products, like melatonin, chewables and liquids may be popular. For herbal formulas, capsules and liquids dominate, but we find that the chewables and capsules sell best for melatonin. Aminos tend to be in powders, chewables, and capsules, with the occasional tablet form.

Sometimes obvious things like limiting caffeine, setting nighttime winding down rituals, and creating a calm space for sleep can be helpful.

Superfruits and ORAC value

2011-03-22T15:10:00.000-05:00

A normal piece of fruit may have hundreds of ORAC units, a laboratory measure of antioxidant activity in a test tube. A “superfruit” may have tens of times higher antioxidant activity than our common fruits. Part of the reason for this is the environmental conditions of superfruits: some of them come from rainforests; others from more arid regions. It has been shown in studies that plants make antioxidants in response to environmental challenges such as droughts, variations in nutrient availability, competition with weeds, attacks by molds or bugs, lack of or excess sunlight, and other substandard conditions that are less common in modern chemical agricultural farming. This makes non-conventional crops more nutritious, especially in antioxidant nutrients like polyphenols that have only been compared to conventional crops for about a decade.

ORAC units, being a measure of test tube activity, may not be an ideal way to measure antioxidant potential in a food. However, it does give us a comparative measure of antioxidant compounds in various foods. The fact that these numbers may not accurately reflect their ability to act as antioxidants in the human body has become an issue, but until we get a better measure, or determine exactly which compounds measured by ORAC are used in what ways, this imperfect method still gives us a useful yardstick for nutritional density related to the foods’ antioxidant potential.

Naturally, numerous factors will affect the price and availability of superfruits including long supply chains, weather, transport costs, supply-and-demand, etc. Several superfruits are predicted to have an enduring market presence: Acai, Goji, Mangosteen, Noni, and Pomegranate. Maqui berries possess among the highest known ORAC value (Oxygen Radical Absorption Capacity) of any superfruit. Maqui berries are purple berries rich in anthocyanins.

It’s important to realize that rainforest fruits play a role in preserving tropical rain forests. If the indigenous people can make a living by harvesting wild fruit from mature trees, rather than finding it advantageous to clear cut to farm corn and soybeans, you can see that their vested interest would lie in protecting that forest from developers. Wildcrafted fruit would tend to be more nutritious in antioxidants than orchard-grown fruit, based on the results of comparative studies showing that environmental diversity protects and challenges the plants to produce protective phytochemicals that serve as human nutrients. Of course, these superfruits are not necessarily locally sourced, but they are extremely nutritious and do help to preserve the rainforests.

It’s important to note that the federal government refuses to recognize “structure-function” claims made on foods, which do not have DSHEA protections. You’ve probably heard that food companies touting the benefits of their own superfoods – cherries, fortified OJ, probiotics, pomegranate juice – have been targeted by federal agencies enforcing their rules that all food claims go through the tedious approval process of publishing in the Federal Register, etc. In this regard one can make more claims on a dietary supplement label – if properly documented – than on a food label.

Iodine and Exposure to Radioactive Nuclear Emissions

2011-03-15T04:58:00.002-05:00

What is iodine?

Iodine (I) is a mineral that is essential to human health, which we use to make the thyroid hormones thyroxine (T3) and triiodothyronine (T4). These hormones regulate our metabolism, synthesis of protein, enzymatic activity, and other biochemical reactions. They are also essential to unborn children’s and infants’ development of skeletal and nervous systems. Iodine deficiencies cause goiter; an enlargement of the gland. In addition to thyroid functions, iodine has a role in immunity, including breast health. [1]

How do we absorb iodine?

The element iodine is a gas, but we ingest it as a solid salt and that compound is known as iodide. For example, the potassium salt form of iodine is known as potassium iodide (KI). Iodine readily absorbs (about 96%) in the upper intestine (stomach and duodenum). [1]

How much iodine should we normally have?

Of the 15-20 mg present in a healthy adult, 70-80% is stored in the thyroid gland. Excess iodine is excreted in the urine. These iodine concentrations are considered adequate in urine samples:

• 100–199 mcg/L in children and adults
• 150–249 mcg/L in pregnant women
• Over 100 mcg/L in lactating women

Values lower than 100 mcg/L in children and non-pregnant adults indicate insufficient iodine intake, and urinary iodine levels lower than 20 mcg/L are considered severe deficiencies.

The US RDA for iodine is:
Table 1: Recommended Dietary Allowances (RDAs) for Iodine [2]

Birth to 6 months 110 mcg*
7-12 months 130 mcg*
1-3 years 90 mcg
4-8 years 90 mcg
9-13 years 120 mcg
14-18 years 150 mcg
14-18 years Pregnant 220 mcg
14-18 years Lactation 290 mcg
19+ years 150 mcg
19+ years Pregnant 220 mcg
19+ years Lactation 290 mcg

* Adequate Intake (AI)
However, international health agencies recommend that pregnant women get 250 mcg daily.

Typically, mountainous areas and areas subject to flooding have lower soil levels of iodine. Cruciferous vegetables are goitrogenic (inhibit the thyroid’s absorption of iodine), as are deficiencies of vitamin A or iron.

It takes numerous grams (one gram = 1,000 mg or 1,000,000 mcg) of iodine to cause overt toxicity, though side effects are possible at lower amounts. As with some other vitamins and minerals, symptoms of excess mimic those of deficiency. For iodine, these include goiter, elevated thyroid stimulating hormone (TSH) from the pituitary gland, and hypothyroidism (low thyroid function).

This table from the Institute of Medicine lists maximum recommended levels of supplemental iodine. These levels reflect a comfortable safety margin and few people would have side effects from taking iodine up to the amounts shown. In the event of a radiation emergency, higher amounts may be recommended by public health authorities.
Table 3: Tolerable Upper Intake Levels (ULs) for Iodine [2]

Birth to 6 months Not possible to establish*
7–12 months Not possible to establish*
1–3 years 200 mcg
4–8 years 300 mcg
9–13 years 600 mcg
14–18 years 900 mcg
19+ years 1,100 mcg

* Formula and food should be the only sources of iodine for infants.

Additionally, potassium iodide supplements may interact with some drugs including anti-thyroid medications used to fight overactive thyroid (hyperthyroidism), certain blood pressure medicines (angiotensin-converting enzyme (ACE) inhibitors), and potassium-sparing diuretics. [1]

What are the causes of possible exposure to radioactive iodine?

Radioactive iodine-129 (I-129) and iodine-131 (I-131) are produced by the fission of uranium atoms during the operation of nuclear reactors. Iodine-129 is also formed as a result of nuclear weapon explosions, the source of most of the radioactive iodine in our environment. [1]

How is radioactive iodine dangerous to human and animal health?

The body uses both normal (“stable”) and radioactive iodine, not being able to distinguish between them. Radioactive iodine can cause thyroid problems, yet it is also used to help diagnose and treat certain thyroid problems. Long-term exposure to radioactive iodine can cause nodules or cancer of the thyroid, but treatment with high doses of I-131 (the rapidly decaying one) may be used to treat thyroid cancer. Doctors also use lower doses of I-131 to treat overactive thyroids. [1]

How long is radioactive iodine dangerous?

While iodine-129 persists in the environment for millions of years, iodine-131 has a half-life (the time it takes for it to decay to 50% of the original amount) of only 8 days and will decay completely within months. Radioactive iodine is water soluble and can be ingested by drinking it in contaminated water, inhaling it as an airborne gas, eating produce that has it on the surface, eating fish that have absorbed it from the water, or from consuming milk or meat from animals that have eaten plants exposed to radioactive iodine. While iodine mainly collects in the thyroid gland, where it has a half-life of about 100 days, there are iodine receptors in other parts of the body - such as bone, kidney, spleen, and reproductive organs – where it has much shorter half-lives. [1]

What do public health authorities recommend to limit absorption of radioactive iodine?

In emergencies large doses of stable iodine are used to flood the bloodstream to help prevent the thyroid gland from taking up radioactive iodine, since raising the concentration of stable iodine in circulation would make it far less likely that the gland will absorb much radioactive iodine. These very high doses of stable iodine are not intended for daily use and may be hazardous for some people. [1]

What are good sources of stable iodine?

High dose potassium iodide in pills or capsules is the form given when public health authorities distribute iodine to populations at risk of radiation exposure.

Seafood, including fish and seaweed, and dairy products (due to fortified feed and iodine-based sanitation products used in milking, but the use of both of these are reportedly on the decline) provide significant amounts of stable iodine in the diet, but not enough to block the entry of radioactive iodine into the thyroid gland when an emergency is present.

Seaweeds have a flaw in that they typically contain less that 1% iodine by dry weight and also may contain undesirable heavy metals that are considered safe at recommended levels. In other words, don’t rely on kelp or dulse for much more than the RDA, or at most the UL (see above), because the levels of arsenic or other metals might also rise enough to become potential health hazards.

Iodized salt also provides essential iodine that can compete with radioactive iodine; a 1.5 gram serving (about ¼ teaspoon) provides about 71 mcg of iodine. Processed foods rarely use iodized salt, which must be declared on the label. However, there is only enough iodine in iodized salt to nourish the thyroid gland, not enough to exclude radioactive iodine from entering and causing harm. [1, 3]

Large doses of stable iodine reportedly protect the thyroid from accumulating radioactive iodine by competitively excluding that form because the thyroid is already full of stable iodine.

How much iodine should I take, and when?

“According to the FDA, the following doses are appropriate to take after internal contamination with (or likely internal contamination with) radioactive iodine:

•Adults should take 130 mg (one 130 mg tablet OR two 65 mg tablets OR two mL of solution).
•Women who are breastfeeding should take the adult dose of 130 mg.
•Children between 3 and 18 years of age should take 65 mg (one 65 mg tablet OR 1 mL of solution). Children who are adult size (greater than or equal to 150 pounds) should take the full adult dose, regardless of their age.
•Infants and children between 1 month and 3 years of age should take 32 mg (½ of a 65 mg tablet OR ½ mL of solution). This dose is for both nursing and non-nursing infants and children.
•Newborns from birth to 1 month of age should be given 16 mg (¼ of a 65 mg tablet or ¼ mL of solution). This dose is for both nursing and non-nursing newborn infants.
A single dose of KI protects the thyroid gland for 24 hours. A one-time dose at the levels recommended in this fact sheet is usually all that is needed to protect the thyroid gland. In some cases, radioactive iodine might be in the environment for more than 24 hours. If that happens, local emergency management or public health officials may tell you to take one dose of KI every 24 hours for a few days. You should do this only on the advice of emergency management officials, public health officials, or your doctor. Avoid repeat dosing with KI for pregnant and breastfeeding women and newborn infants. Those individuals may need to be evacuated until levels of radioactive iodine in the environment fall.” [3]

Taking a higher dose of KI, or taking KI more often than recommended, does not offer more protection and can cause severe illness or death.

When public health or emergency management officials tell the public to take KI following a radiologic or nuclear event, the benefits of taking this drug outweigh the risks. This is true for all age groups. Some general side effects caused by KI may include intestinal upset, allergic reactions (possibly severe), rashes, and inflammation of the salivary glands.

When taken as recommended, KI causes only rare adverse health effects that specifically involve the thyroid gland. In general, you are more likely to have an adverse health effect involving the thyroid gland if you

•take a higher than recommended dose of KI,
•take the drug for several days, or
•have pre-existing thyroid disease.

Newborn infants (less than 1 month old) who receive more than one dose of KI are at particular risk for developing a condition known as hypothyroidism (thyroid hormone levels that are too low). If not treated, hypothyroidism can cause brain damage. Infants who receive KI should have their thyroid hormone levels checked and monitored by a doctor. Avoid repeat dosing of KI to newborns.

Limitations of large dose stable iodine [3]

• Stable iodine may protect the thyroid if taken at the right time and at a high dose. However, it is not proven to protect other parts of the body and stable iodine does not block the radioactive form from the body.
• That limited protection for the thyroid from taking high dose stable iodine only lasts for about 24 hours.
• Stable iodine does not protect the body from any other radioactive materials that may be in the environment.

Final thoughts

People in other countries, such as the United States, will not experience the amount of radiation that those in the immediate vicinity of the nuclear plants could. Since the high-dose potassium iodide (KI) works to protect the thyroid gland only for about 24 hours, it is probably wise to wait for a specific event to actually take that pill. Meanwhile, a reasonable daily dose of iodine within tolerable upper limit (UL) levels (between 200-1,100 mcg; see above) is probably wise to maintain some level of protection against potential low level increases in airborne radioactive iodine and to assure adequate levels in the thyroid so it’s not so anxious to take in whatever form is circulating in the body and there is plenty of the stable form available. High-dose seaweeds like kelp and dulse may also provide heavy metals in excess of safety recommendations and should only be taken at levels closer to the RDA.

REFERENCES:

Essential fatty Acids (EFAs) interview, Natural Products Marketplace magazine, January, 2011

2011-03-07T13:03:00.000-06:00

The awareness of EFAs, especially the Omega-3 fatty acids EPA and DHA, is large and growing larger. The accumulating mountain of evidence and the endorsement by popular health “gurus” assures continued growth in this important product category. As the benefits of specific fatty acids for regulation of various healthy body functions – such as inflammatory processes, hormonal health, and maintaining brain/nerve/cellular structures – becomes even more well known, more and more people recognize the potential for EFAs to positively affect their health.

While there are combination products that deliver Omega-3, Omega-6, and Omega-9 fatty acids together, the focus has been more on specific sources such as fish or flax, along with some more unusual ones. Of course, natural oil sources are not comprised of a single fatty acid. For example, natural fish oil can not only supply EPA and DHA but also originally supplies ALA, cholesterol, triglycerides, and other fatty acids; though many of these components can be removed during processing to provide purer and stronger materials that are richer in EPA and DHA to require far fewer capsules to reach desired levels of these two fractions. Flax oil is best known as a vegetarian source of the omega-3 fatty acid ALA (alpha-linolenic acid), but ALA levels are only about 55% of the total; flax oil also contains about 19% omega-9 as oleic acid, 14% omega-6 as linoleic acid, and 12% saturated fats. The conversion of ALA to EPA is a significant metabolic hurdle. Women do this conversion better than men; people who consume the most omega-6 in their diets have a more difficult time converting ALA to EPA. Typically between 5% and 15% of ALA converts to EPA and about 2% to 5% of ALA converts to DHA, making flax a much more dilute and less certain source of EPA-DHA.

Fish oil is subject to environmental concerns related to both sustainability and contaminants. Manufacturers audit their suppliers and set strict identity/safety specifications to assure the quality of products.

Most fish oils are molecularly distilled to remove contaminants, manufactured under strict quality assurance standards, and screened to be free of potentially harmful levels of contaminants and heavy metals, such as mercury, PCB’s, dioxins, and others.

Other types of EFAs include Flax seed oil, Evening Primrose Oil, Pumpkin seed oil, Black Currant seed oil, Wheat Germ oil, Castor Oil, and Virgin Coconut Oil.

Purity, potency, and freshness are always the challenges with EFAs.

The trend is toward more concentrated products of higher purity that allow people to get their EPA and DHA with smaller quantities of capsules or less volume of liquid. Liquids and smaller capsule sizes allow more children and seniors to enjoy the benefits of fish oils, while high strength capsules better hit the main demographic in between.

All fish oil supplements are typically hundreds of times safer than eating a serving of fish in relation to environmental factors; and typical esterified products have the added benefit of being free of cholesterol and triglycerides, which are undesirable food components for those with high cholesterol. By far, most of the studies proving the health benefits of supplemental fish oils have been with the esterified (ethyl ester) form, rather than the triglyceride form found in cold water fatty fish. There is very strong science supporting the use of this form.

Esterified fish oils also have been shown to sustain human serum levels better than the triglyceride form, over both a 24-hour period and a one-month period, which better supports a healthy heart rhythm. Notably, the most concentrated products are available only as esterified fatty acids. The ability of a consumer to get the 1-3 grams daily of EPA + DHA recommended by many health experts is enhanced by modern formulas that concentrate these essential fatty acids into fewer capsules and smaller serving sizes with fewer undesirable components, thus increasing customer compliance with a healthy nutritional protocol.

Both triglyceride and esterified ethyl ester fish oils are available in the marketplace, and both forms have their advocates. In the body, both forms must first be digested, stripping off the triglycerides or ethyl esters and leaving only free fatty acids that can be readily absorbed. These free fatty acids are then combined with triglycerides present in the liver before entering general circulation; so the circulating form will actually be the triglyceride form, no matter which form of fish oil one consumes. Both forms provide great value and important nutrients for the consumer; but the triglyceride form has no more proven value than the ethyl ester form, despite some excessive marketing claims.

ADULT WEIGHT MANAGEMENT interview, Vitamin Retailer magazine, February, 2011

2011-03-07T12:51:00.000-06:00

Weight management products have long been an important category for natural product retailers, partially because it is such a problem for many people to control their weight but also since many people shop in these stores because they want to use natural products that are free of potentially risky pharmaceuticals. As a gateway category for transitional shoppers that may be new to health food stores, weight management products become an important gauge of a commitment to meeting these people’s needs and thus keeping them as customers willing to try other products. Of course, nutritionists will suggest a comprehensive diet and supplement plan, rather than relying on “magic bullet” single products.

Good Manufacturing Practices (GMP) regulations have gone into effect over the past several years, raising the bar on manufacturers’ quality control practices. At the same time, mandatory Adverse Event Reporting (AER) was also implemented. Both of these regulatory mechanisms should increase consumer confidence and belie the myth that the industry is “unregulated”.

I believe that the glut of stories about Americans being overweight tends to make people more aware of their own lack of exercise and dietary restraint, which contribute to their excess weight. Of course, health scares and medical crises also alert people to their mortality and tend to motivate healthy dietary and other lifestyle changes. Today’s youth-obsessed media makes people want to look young and fit even past middle age. Plastic surgery, being expensive and with some risks, is far from a perfect solution. There are no shortcuts to health, only natural aids to good health. The very visible failures of both diet drugs and illegal products pretending to be dietary supplements illustrate the depth of the market and the need for effective natural weight management products.

Consumers tend to look for something that was recommended to them, either by a person or an authority. The person could be a family member, co-worker, or an acquaintance. The authority could be someone cited in the media, on the Internet, or a trusted trainer or health professional. Top categories are controlling appetite (satiety), increasing metabolism (thermogenics), and blocking the absorption of certain food components such as carbohydrates or fats (nutrient blockers).

Natural foods and fibers are part of the solution to maintaining healthy weight and blood sugar. These foods would include whole grains as well as fibers from various sources. Some of these fibers are gluten-free and/or organic, such as Flax, Acacia, Inulin, and Psyllium. Fibers also help satiety, the feeling of being full.

Consumers today are more concerned about the quality and safety of diet support products, so are looking for assurances of adequate quality controls and testing. Some parts of this process include method validation and development, stability testing, identity testing, microbiological testing, heavy metal testing, specification development, overseeing production, procuring samples and preparing them for testing, and even raw material vendor audits.

2011-03-04T10:10:00.000-06:00

A study found that about 1/4 of all otherwise normal infants have evidence of infantile rickets while still in the womb. It is likely that tens of thousands of infants are being sent home from the hospital with multiple fractures because no one has ever done a study looking for asymptomatic fractures.

Mahon P, et al. Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res. 2010 Jan;25(1):14-9.

Nutrients for Bone and Joint Health Interview

2011-02-08T17:04:00.000-06:00

This interview was given to Whole Foods Magazine, excerpts were published in the February 2011 issue:

Despite evidence in recent medical journals, including several review studies calling for a far higher RDA and UL (upper limit) that would be five times the previous levels, the IOM held true to its conservative bent and raised the RDA and the UL; but only by 50% by only 100%, respectively . Observers are somewhat disappointed, but not really surprised. The most controversial part of the IOM committee’s report is that the only proven role for vitamin D is in bone and calcium metabolism, combined with its finding that most Americans already get enough for those benefits. That should come as news to researchers from Mayo Clinic operating under an NIH grant who recently reported that “Vitamin D insufficiency is common globally and in the United States. Approximately 25-50% of patients seen in routine clinical practice have vitamin D levels below the optimal range…” It also should be news to European regulators that recognize vitamin D’s beneficial effects on muscles, immunity, inflammation, cellular health, and reproduction. We recognize the new increased recommendations for vitamin D and the new higher safety recommendation, but believe that these numbers are insufficient to support vitamin D’s roles that go beyond calcium and bone health.

The need for joint and bone health nutrients in general increases with age. Aging also tends to reduce absorption of nutrients, forcing us to take higher amounts and better forms in order to assure adequate nutrition. The tendency of many seniors to cut back on meals, for reasons such as loss of taste or smell or interest in cooking, may also increase the need for supplementation of essential nutrients. The major joint and bone problems increase with age, and studies have shown the ability of relevant nutrients to maintain healthy bone and joint structures during these vulnerable times of life. Older customers that are more likely to take calcium supplements also tend to have diminished stomach acid available for digesting calcium from food and non-chelated (predigested) forms, so tend to do better with the predigested forms. These include calcium as citrate, malate, ascorbate, or bonded to specific amino acids; all are weak acidic sources that form a stable bond with the alkaline calcium and the resulting compound simulates the calcium complexes formed naturally during proper digestion.

While calcium and vitamin D are known for their role in bone and calcium metabolism, there are other nutrients necessary for bone health. These include silica, boron, magnesium, vitamins C and K, etc. protein. Comprehensive bone formulas include over a dozen nutrients, which are also available singly.

Children need to get sunshine, exercise, and a variety of calcium from food sources to ensure the body’s needs for bone health. If the child does not eat ample amounts milk and dark green leafy vegetables, they may need to complement the diet with appropriate dietary supplements.

Adults need to take care of their bodies and not impact the joints too much with hard exercises or excess weight. Support the joints nutritionally with glucosamine, vitamin C, a good multivitamin, and natural substances that modulate inflammation.

One should not neglect the long-term benefits of glucosamine to maintain joint distances that may otherwise erode, for example, while seeking fast-term temporary relief of aches and pains. By providing those products in both categories as well as overlapping combination products, we can supply a more holistic and sustainable nutritional joint support program.

Many of the Joint Structural Support Products contain varying amounts of glucosamine and/or chondroitin, as well as MSM, Hyaluronic Acid, and other well-known ingredients.

2011-01-27T15:21:00.000-06:00

Dear reader,

I've had comments from readers wanting me to look at or debate specific studies that are perhaps contradictory to ones that I cited. I sometimes think that this not really productive; in the sense of 'why debate how much phytoestrogens are in foods?' when the questioner's intention seems be to help people avoid these benign/beneficial substances which are shown (at the highest levels of intake!) to prevent cancer (lowers risk of certain cancers by about 30%) and heart disease while blocking the truly harmful xenoestrogens (external sources like agricultural and industrial chemicals or plastics) from docking to cellular receptors.

And I don't really want to publish people's comments that include links that send people to other websites; especially if they are not authoritative and non-commercial. In most cases I provide my own references and will happily publish relevant comments that avoid such links; though I of course reserve the right to debate these comments with a follow up comment of my own if I disagree with the point(s) being made.

I also don't want to debate the merits of whatever "expert" someone wants to throw at me because we all know that there are plenty of voices of all levels of credibility on the Internet; many do not list references (or data-dump bogus (irrelevant or unsupportive) ones as soy critics often do), evidently preferring to hear themselves pontificate rather than to review topics from a real scientific curiosity that allows for minds to expand and change. Even the real experts often disagree, since that is the nature of the scientific method; though I have seen the rare term "proven" applied to research on soy's benefits for heart health.

I believe that YOU are smart enough to compare arguments and consider the merits of everyone's "facts" and opinions. As you see from the published comments from readers on my own blog, I do respect, read, and reply to your comments and even appreciate a "healthy" debate on topics that are also important to you. While no one is perfect (especially me), at least I aspire to know my limitations and try to do the right thing. Hopefully, you will carefully read my blog and consider me to be a trusted source providing "Honest Nutrition". Thanks for letting me share this page with you!

Nutrients for Heart Health interview

2011-01-27T14:38:00.000-06:00

From an interview of me by Whole Foods Magazine, february 2011:

Our aging population will naturally turn to nutrients as a core defense of their heart and cardiovascular (CV) health. Research continues to pile up to support the benefits of various vitamins, minerals, amino acids, herbs, antioxidants, and other dietary supplements to optimize heart health. The trick is to communicate clear benefits associated with specific nutrients and formulas while treading on the right side of the label claims limits.

There are products that support various aspects of CV health. These include circulation, vascular health, heart energetics, fat metabolism, stress and cortisol control targeting abdominal fat, electrolyte metabolism, etc.

Additional heart support could be associated with blood sugar health, since diabetics disproportionately suffer and die from cardiovascular disease. Supporting nutrients to maintain healthy glucose metabolism include alpha lipoic acid, chromium, cinnamon, biotin, Gymnema sylvestre, corosolic acid, and others. The use of stevia as a sweetener can also be helpful in cutting carbohydrate intake; the whole herb, not the “Reb A” fraction commonly sold as a mass market sweetener, also has been shown to have supportive effects on pancreatic function, insulin sensitivity, and antioxidant benefits.

Many isolated nutrients have historically been used to support cardiovascular health, including amino acids (l-arginine, l-citrulline, l-carnitine), lecithin, vitamin E complex, CoQ10, B complex vitamins, methylators like TMG and SAMe, magnesium, antioxidants, plant sterols, sugar cane policosanol, and nattokinase. At the same time there are many botanicals for the same purpose such as hawthorn leaf and flower extract (not the berries, which are not shown to help the heart), and prickly ash bark. Whole foods or botanicals that support heart health include cayenne, garlic, ginger, cayenne, and whole fermented organic red yeast rice. And let’s not forget the benefits of fish oils and fiber, which do have FDA-approved qualified health claims.

Vitamin D also has a role in heart health, a benefit which the Institute of Medicine’s committee that released the new dietary recommendations did not endorse. By contrast, the FDA’s European counterpart EFSA (the European Food Safety Agency) has acknowledged a role for vitamin D in heart health: "The Panel concludes that a cause and effect relationship has been established between the dietary intake of vitamin D and contribution to the normal function of the immune system and healthy inflammatory response, and maintenance of normal muscle function." The heart, of course, is a muscle; the body’s control of inflammation, calcium metabolism, and muscle function are all intimately related to heart health.

I'm now on Twitter

2011-01-23T21:38:00.000-06:00

Look for a few messages a week related to nutrition from my Twitter tweets:

http://twitter.com/#!/neilelevin

2011-01-10T10:16:00.000-06:00

Keyboard shortcuts for commonly used symbols in science and math

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What's the difference between non-GMO and organic?

2011-01-10T09:40:00.000-06:00

IP-Certified Organics are produced without GMOs (genetically modified organisms) but are not tested for potential GMO contamination by pollen drift, etc. The IP stands for 'identity preserved"; in other words, there is an audit trail documenting the production and process inputs and a third party certifier overseeing and signing off on the paperwork. All crops and foods produced under this designation meet U.S. Department of Agriculture (USDA) regulations under its National Organic Program (USDA-NOP) that include allowable and non-allowable agricultural and food production inputs. Such inputs include irradiation (not allowed), agricultural chemicals (only natural source ones allowed), and GMOs (not allowed). Theer are also lists of allowed/not allowed food addititives and rules for making label claims for organics.

IP-non-GMO certification is similar, but this certification is only for processes that exclude introducing GMO substances or seeds. The difference is that there are other restrictions as to what is allowed to be used with organics that don't apply to non-GMO conventional foods. For example, agricultural chemicals, synthetic food additives, etc are allowed with non-GMO but not for certified organics.

Testing is another issue. Testing of such products is not widely done, and studies have shown that there is less GMO contamination of certified organics than conventional crops when neither is supposed to contain GMOs. Exports to Europe may require GMO testing to be done and results must be under a threshold (typically 0.5% maximum). But most certified organic and non-GMO certified ingredients are not tested for residual GMOs that could have gotten in by seed contamination, pollen drift, handling errors, etc. and this is usually not considered to be a significant problem that requires testing.

Mercola, Weston Price wrong on Soy "dangers"

2010-12-16T16:59:00.000-06:00

I regularly see research on soy and the vast majority of research papers prove the health benefits of soy. Based on the body of science and the errors evident in his "Facts", what Dr. Mercola has stated is undocumented, unreferenced bull recycled from Weston Price.

All legumes contain significant levels of phytoestrogens; why is soy singled out for this abuse using cherry-picked out-of-context "facts" that aren't really backed them up when the research is reviewed. Do you ever hear such slanders against the #2 source of phytoestrogens (pinto beans)?

In fact, many of the negative studies cited come from the animal feed industry and refer to raw defatted soy meal, the pulp left over after extracting soybean oil. This is not what humans eat! We aren't fed raw defatted soy meal as the major protein source in our diet, and many of the negative issues with raw dried soybeans disappear with proper food preparation (i.e., cooking). They also don't apply to edamame (raw soybean pods with the beans inside), since some of these "anti-nutrient" factors form during drying and are removed during cooking (except for genetically engineered soy that contains exceptionally heat-resistant anti-nutrient compounds).

Here are some actual facts about soy (in contrast to the Mercola/Weston Price data dump of uncritically collected studies); and I have the studies to back this up:

Phytates are common in grains, less in legumes; the supplement IP-6 is this exact compound, useful to stimulate NK cells and immunity
Trypsin inhibitors are only a problem in raw soy flour and GMO soy products, not the typical uses of non-GMO soy
Phytoestrogens such as isoflavones are not endocrine disruptors, this is nonsense; have you ever heard of these problems with pinto beans, the #2 most abundant food source and a major component of the Mexican diet? Of course not.
Soy, like cruciferous vegetablles, only affects thyroid function if one is iodine deficient and the addition of iodine to the diet corrects this symptom. The real problem is a nutrient deficiency.
Most plant foods are known to be poor sources of bioavailable B-12, not just soy, and this is common knowledge so why single soy out? Bias?
D-2 is a natural compound found in the food supply and is neither toxic nor a synthetic form; all vitamin D is produced by chemical synthesis, whether in the body or in a lab, but the forms of D-2 and D-3 utilized in supplements and food fortification are both nature-identical natural forms synthesized in labs.
Most soy protein isolate is not denatured; by the way, another term for denaturing is "digestion" and this is good unless you need intact proteins from food (as in whey protein isolate's valuable immunoglobulins).
All proteins when digested produce free glutamates; this is natural. Only susceptible people who have had severe chemical exposure or are low in protective nutrients like antioxidants and magnesium suffer from this. I have spoken with and attended lectures by Russ Blaylock for about 20 years and am well versed in this mechanism and its causes and solutions.
Soy proteins do not test high in heavy metals; rice protein is actually far higher in actual tests at parts-per-billion detection levels.
Asians consume far more soy products than is claimed by your sources; the typical isolflavone content of the diet there is established to be about 50 mg daily, the amount found in a couple ounces of soy protein at 90% strength, which represents several ounces of unconcentrated soy at about 30% protein.
Soy is not carcinogenic; review studies confirm that soy protein isolate, not fermented soy, has been proven to reduce cancer rates from breast, prostate, and colorectal cancers by about 30%.
Soy upregulates Phase 2 liver detoxification, much like cruciferous vegetables, and is actually a detox aid rather than a source of toxins.
Long term studies of infants fed soy formula find no differences in age of puberty, sexual maturity, or other hormonal measures; soy is 'implicated" only by those unwilling to openmindedly review the research to confirm or prove false their wild theories.
PS, I was in China recently and they eat plenty of tofu and edamame, both unfermented soy foods, in greater quantities than fermented soy.

Some of Weston A. Price Foundation's citations listed as "evidence" of soy's "toxicity" include these titles that obviously don't fit the negative label; that's why I characterize their list as a "data dump":

"Salt poisoning due to ingestion of soy sauce." (How does this prove that non-fermented soy is toxic?)
"Hypothesized health benefits of soybean isoflavones." (A study that is positive of soy's health benefits)
"Rhinitis and dermatitis caused by exotic woods." (This is a non-soy herb: Pterocarpus soyauxii)
"A nutritional comparison of rapeseed oil and soybean oil."
"[Concerning the absence of goitrogenic factors in soybean oil for cooking.]" (Exonerates soybean oil from thyroid issues)
"Eastern black nightshade: An increasing concern for soybean and forage producers." (A farming issue, not a nutritional one)
"Medicinal Plants of lndia and Pakistan." (Actually refers to a non-soy plant: Indian red wood tree, Soymida febrifuga Adr. Juss.)

Increased US Vitamin D Recommendations

2010-12-16T16:37:00.000-06:00

Chicago Tribune’s report “Don’t overdo vitamin D, calcium, experts warn” focused only on the risks of taking very high doses of these essential nutrients but missed the most important part of the new NIH Institute of Medicine (IOM) report by omitting that there are now higher daily recommended allowances (RDA) for vitamin D intake. It’s uncommon to take toxic amounts of vitamin D but far more common for some to be deficient, with resultant health deficits and increased healthcare costs.

Trib readers didn’t learn that the IOM panel raised vitamin D’s RDA by 50% to 600 IU (800 IU if over age 70), while doubling the tolerable Upper Limit (UL) to 4,000 IU.

In Chicago, it’s already been months since we could make any of the “sunshine vitamin” from sunlight, since the sun must be high enough in the sky so one’s shadow is shorter than his/her height. Darker skin allows less vitamin D production even with adequate sunlight; sunscreen blocks it. Chicagoland residents must rely on fortified foods and dietary supplements as primary sources of vitamin D for over half the year.

The IOM statement that people get enough vitamin D refers only to its conclusion that bone health is the only as yet proven role for this nutrient. Yet the IOM’s European counterpart, the European Food Safety Agency, recognizes an established cause and effect relationship between vitamin D and normal muscle health, immunity, inflammation, reproduction, and cellular health. Researchers have estimated that these additional benefits occur when people take 1,000-2,000 IU daily. Scientific toxicity reviews show safety up to intakes of 10,000 - 20,000 IU daily; multiples of the recently doubled UL.

By ignoring vitamin D’s increased RDAs and other benefits, and publishing broad statements that focus primarily on the unlikely “risks” of vitamin D and calcium supplementation, Tribune readers missed important parts of the IOM report.

New evidence that many Americans don't get sufficient vitamin D!

2010-12-07T14:39:00.002-06:00

These quotes are from an NIH-funded study at Mayo Clinic, just published by the the American Society of Hematology in its medical journal "Blood" (Shanafelt TD, et al. Vitamin D insufficiency and prognosis in chronic lymphocytic leukemia (CLL). Blood. 2010 Nov 3. PMID: 21048153). It suggests that 30-40% of the general population is deficient in vitamin D, and that this vitamin has a "central role" in the body beyond bone health:

"Vitamin D insufficiency is common globally and in the United States. Approximately 25-50% of patients seen in routine clinical practice have vitamin D levels below the optimal range, and it is estimated that up to 1 billion people worldwide have vitamin D insufficiency." 1-3

"Vitamin D has a central role in maintaining serum calcium and skeletal homeostasis as well as multiple other cellular effects including regulation of differentiation, proliferation, apoptosis, metastatic potential, and angiogenesis.5 Several reports now suggest low serum 25(OH)D levels may be associated with increased incidence of colorectal,6,7 breast,8,9 and other cancers.10 Consistent with these results, one population based, double-blind, randomized placebo-controlled trial found women who increased their daily vitamin D intake by 1100 IU reduced their risk of cancer by 60-77%." 11

"Consistent with the prevalence of hypovitaminosis D in the general population,1-3 30-40% of CLL patients in the two observational cohorts studied had vitamin D insufficiency."

These quotes cited the following references in the statements posted above:

1.Thomas MK, Lloyd-Jones DM, Thadhani RI, et al. Hypovitaminosis D in medical inpatients. N Engl J Med. 1998;338(12):777-783.
2. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006;81(3):353-373.
3. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357(3):266-281.
5. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab. 2009;94(1):26-34.

6. Gorham ED, Garland CF, Garland FC, et al. Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol. 2005;97(1-2):179-194.
7. Yin L, Grandi N, Raum E, Haug U, Arndt V, Brenner H. Meta-analysis: longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther. 2009;30(2):113-125.
8. Crew KD, Shane E, Cremers S, McMahon DJ, Irani D, Hershman DL. High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy. J Clin Oncol. 2009;27(13):2151-2156.
9. Chen P, Hu P, Xie D, Qin Y, Wang F, Wang H. Meta-analysis of vitamin D, calcium and the prevention of breast cancer. Breast Cancer Res Treat. 2009.
10. Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: global
perspective. Ann Epidemiol. 2009;19(7):468-483.
11. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium
supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007;85(6):1586-
1591.

European regulators recognize effects of vitamin D beyond bone health

2010-12-06T10:36:00.000-06:00

To date EFSA (the European Food Safety Agency), has published positive opinions on article 13.1 health claims relating to beneficial effects of vitamin D supplements not only on bones and teeth, but also relating to muscles, immunity, inflammation, and reproduction. * Yet the United States' Institute of Medcicine (IOM) committee did not reach similar conclusions and therefore did not consider the need for amounts higher than needed just for bone health when recently resetting the recommended and upper limits for vitamin D. (* from nutraingredients.com). For more on the FDA decision, see:
http://honestnutrition.blogspot.com/2010/11/us-increases-recommendations-for.html

Here's what the EFSA has published about these positive benefits (I bolded some text to highlight these points):

"The Panel concludes that a cause and effect relationship has been established between the dietary intake of vitamin D and contribution to the normal function of the immune system and healthy inflammatory response, and maintenance of normal muscle function."
http://www.efsa.europa.eu/en/scdocs/scdoc/1468.htm

"The Panel concludes that a cause and effect relationship has been established between the dietary intake of vitamin D and maintenance of normal bone and teeth, absorption and utilisation of calcium and phosphorus and normal blood calcium concentrations, and normal cell division."
http://www.efsa.europa.eu/en/scdocs/scdoc/1227.htm

U.S. Increases Recommendations for Vitamin D Intake but Misses the Mark

2010-11-30T18:15:00.001-06:00

U.S. Increases Recommendations for Vitamin D Intake but Misses the Mark

As you probably know from news reports, the recommendations for individual consumption of vitamin D has now increased, as has the tolerable Upper Limit (UL) that indicates a higher intake level at which the vast majority of people will not suffer any unpleasant side effects. But these recommendations are controversial for being too conservative, and at the same time the report has been sensationalized in the popular media with an inappropriate emphasis on possible side effects of megadoses.

The Institute of Medicine (IOM), the health arm of the National Academy of Sciences, is an independent, nonprofit organization that works outside of government to provide unbiased and authoritative advice to decision makers and the public. Through more than three dozen sets of guidelines, known as Dietary Reference Intakes (DRIs), IOM provides estimates of the amounts of nutrients that individuals need to consume each day. Health care professionals and policy makers, including federal nutrition officials who develop nutrition programs as well as the food industry, rely on this guidance from the IOM. The reference numbers that you see on food and dietary supplement labels, such as Daily Values (DV), DRIs, and Recommended Daily Allowances (RDAs), are generated by IOM. (1) These values are also utilized by some foreign governments as authoritative references on which to base their own food and supplement regulations.

The good news is that, in a report issued by IOM on November 30, 2010, the RDA has now increased by 50% (from 400 IU to 600 IU) and the tolerable Upper Limit has now doubled (from 2,000 IU to 4,000 IU). Also, the RDA for adults over 71 years old has increased to 800 IU daily. (2) This means that the new recommendations are often higher than the 400 IU that is found in a typical multivitamin or calcium+D formula, thus requiring additional supplementation to meet the RDA. And the leeway for safe use at the upper end is now double what it was before, making such supplementation at higher levels still within a margin generally accepted as safe; at least up to 4,000 IU, though as usual that number is deliberately set low and has a large safety margin.

IOM’s report stating that most Americans have adequate circulating levels of vitamin D is somewhat controversial, as it utilizes a standard of 20 ng/mL (equivalent to a measure of 50 nmol/L) (3) that is not universally accepted as adequate for optimal health by many modern vitamin D researchers. While that amount may adequately support bone health, which was (as usual) the primary focus of the IOM committee, there are vitamin D receptors on many other human cells and this vitamin reportedly plays an important role in cardiovascular disease (4), immune health (5), prostate and breast health (7), blood sugar metabolism (6), cancer prevention (7,8) , and a host of natural processes. One recent report stated that, “The desirable serum 25 (OH) D levels is at least 100 nmol/L, a level that has generally been found to provide most of the health benefits of vitamin D.” (9) This recommendation is twice as high as the new RDA, evidencing the controversial nature of IOM’s RDA process.

However, the IOM committee admittedly based its recommendations solely on vitamin D’s effects on bone health after reviewing numerous studies on other benefits and concluding that more study is required to generate the level of evidence that IOM requires to set its recommendations. Committee chair Catharine Ross was quoted as saying, “Amounts higher than those specified in this report are not necessary to maintain bone health.” (10) As the amount of science in these other areas grows, so should the levels recommended for general health. But statements such as that by Dr. Ross that “people don't need more than the amounts established in this report” refer only to bone health and should not be construed as denying the fact that other benefits at higher levels of intake have been reported, though not as consistently as the IOM committee would need to accept them as conclusive enough to revise its recommended levels upward.

Based on current research, natural health advocates typically recommend levels 50-100% higher than the IOM report recommends in order for people to obtain the full protective benefits of vitamin D, and many physicians who test for this vitamin ask their patients to meet or exceed that higher level. This is perhaps the most controversial part of the report, and I predict that a barrage of higher numbers appearing in medical reports as protective will force another overdue round of RDA changes in perhaps another 10-15 years. In my opinion, the IOM is always behind the times in the area of nutrient recommendations, being by nature super cautious. We dared to hope, but nobody really expected the IOM panel to accept the evidence of recent published review studies in medical journals and raise both the RDA and UL to the recommended five times their previous levels, and frankly we were not surprised that they didn't. These special panels are typically very conservative and hesitant to make dramatic changes, and are comprised with well-qualified general nutrition experts but not with experts in the particular area in question who might push for acceptance of higher levels.

People have already been taking over 2,000 IU daily, the old tolerable Upper Limit, without apparent harm and will probably continue to take over the new 4,000 IU UL as well. Clinical science indicates that higher levels are still quite safe, at least up to 10,000 IU daily for most adults. In 2007 a review published in the American Journal of Clinical Nutrition applied the same risk assessment methodology used by the Food and Nutrition Board (FNB) to derive a proposed revision of the safe Tolerable Upper Intake Level (UL) for vitamin D. (11) Noting an absence of toxicity in trials conducted in healthy adults that used a vitamin D dose ≥250 µg/d (up to 10,000 IU of vitamin D3), a new UL of 10,000 IU was confidently proposed, but was apparently not accepted by the IOM. Nor was the recommendation for a new RDA to be raised to 2,000 IU.

In fact, the 10,000 IU daily UL proposal may have been conservatively low; so what does that make the revised tolerable UL of only 4,000 IU? According to a report in the journal Nutrition Reviews, "The input needed for efficacy, in addition to typical food and cutaneous [sunlight] inputs, will usually be 1000-2000 IU/day of supplemental cholecalciferol [vitamin D3]. Toxicity is associated only with excessive supplemental intake (usually well above 20,000 IU/day)." (12) [Italicized words added for clarity]

Dietary supplement manufacturers already were not allowed to make disease claims on dietary supplements without (always reluctant) FDA approval, so the IOM’s report that vitamin D has not been proven to prevent various diseases is not news for them. However, consumers will continue to be exposed to positive reports on the vitamin and most will understand that just because it has not yet been "proven" to prevent certain diseases doesn't mean that it doesn't, especially at levels higher than needed purely for bone health, nor does it suggest that there is no supporting evidence that it still may be an important preventative factor.

The government standard of proof in the dietary supplement area has been frequently criticized and the FDA in fact has lost several federal court cases, where courts have ordered the agency to comply with the law allowing such claims where substantial evidence already exists for some supplements’ role in disease prevention (for example, selenium and cancer). (13,14) Of course, almost never is anything "proven" in a scientific field; theories rule most scientific endeavors. But that should not suffice to allow the government to muzzle legitimate science nor to prevent the public from taking natural nutrients at levels that they may require due to their own individual biochemistry and relevant environmental factors. In this case, the new RDA and UL are simply baby steps in the right direction, but perhaps the full knowledge of vitamin D’s health benefits is still in its infancy.

REFERENCES:

http://www.iom.edu/About-IOM.aspx Accessed November 30, 2010
Dietary Reference Intakes for Calcium and Vitamin D. Food and Nutrition Board, Institute of Medicine, National Academies. Released: November 30, 2010
http://ods.od.nih.gov/factsheets/VitaminD-Consumer/ Accessed November 30, 2010
Wallis DE, Penckofer S, Sizemore GW. The "sunshine deficit" and cardiovascular disease. Circulation. 2008 Sep 30;118(14):1476-85. Review. Erratum in: Circulation. 2009 Jun 2;119(21):e550. PubMed PMID: 18824654.
Cannell JJ, Zasloff M, Garland CF, Scragg R, Giovannucci E. On the epidemiology of influenza. Virol J. 2008 Feb 25;5:29. Review. PubMed PMID: 18298852; PubMed Central PMCID: PMC2279112.
de Boer IH. Vitamin D and glucose metabolism in chronic kidney disease. Curr Opin Nephrol Hypertens. 2008 Nov;17(6):566-72. Review. PubMed PMID: 18941348; PubMed Central PMCID: PMC2882033.
Skinner HG, Michaud DS, Giovannucci E, Willett WC, Colditz GA, Fuchs CS. Vitamin D intake and the risk for pancreatic cancer in two cohort studies. Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1688-95. PubMed PMID: 16985031.
Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, Holick MF. The role of vitamin D in cancer prevention. Am J Public Health. 2006 Feb;96(2):252-61. Epub 2005 Dec 27. Review. PubMed PMID: 16380576; PubMed Central PMCID: PMC1470481.
Grant WB, Schwalfenberg GK, Genuis SJ, Whiting SJ. An estimate of the economic burden and premature deaths due to vitamin D deficiency in Canada. Mol Nutr Food Res. 2010 Aug;54(8):1172-81. PubMed PMID: 20352622.
http://www8.nationalacademies.org/onpinews/newsitem.aspx?RecordID=13050 Accessed November 30, 2010
Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin Nutr. 2007 Jan;85(1):6-18. Review. PubMed PMID: 17209171.
Heaney RP. Vitamin D: criteria for safety and efficacy. Nutr Rev. 2008. Oct;66(10 Suppl 2):S178-81. Review. PubMed PMID: 18844846.
http://www.emord.com/FDA_Agrees_to_Allow_Selenium_Qualified_Health_Claims.html Accessed November 30, 2010
http://www.kelleydrye.com/publications/client_advisories/0576 Accessed November 30, 2010

Bitter Orange Safety Concerns Are Overblown: study

2010-11-20T22:01:00.000-06:00

A review of bitter orange safety was published in a peerr-reviewed journal. Analyzing the adverse event reports (AERs) submitted to the FDA, Sidney J. Stohs, dean emeritus of the Creighton University School of Pharmacy and Health Professions, reported that, “The belief that p-synephrine exerts serious cardiovascular and other events continues to be believed by the lay public as well as healthcare professionals, in spite of the lack of clearly defined supportive evidence for this supposition, as well as extensive evidence to the contrary.”

"An 8 oz glass of Californian mandarin orange juice may contain up to 35 mg p-synephrine (USDA). A sweet orange typically contains about 6 mg p-synephrine."

http://www.nutraingredients-usa.com/Industry/Bitter-orange-concerns-unwarranted-and-unjustified-Review/?c=Fe5usULeGc2A9I8d6ljtPw%3D%3D&utm_source=newsletter_daily&utm_medium=email&utm_campaign=Newsletter%2BDaily

Source: Journal of Functional Foods. Published online ahead of print, doi: 10.1016/j.jff.2010.10.003
“Assessment of the adverse event reports associated with Citrus aurantium (bitter orange) from April 2004 to October 2009” Author: S.J. Stohs

Cholesterol measures

2010-11-11T12:53:00.000-06:00

Total cholesterol means nothing in terms of health. Just as many people have fatal heart attacks with low total cholesterol as high, and there are additional health risks if it is too low. Flipping a coin gives you just as good data. I have seen people whose total cholesterol is high but who seem to have little risk. There may also be a genetic component to the baseline total cholesterol number that defies easy changes.

The main relevant and meaningful cholesterol number today is the ratio of total cholesterol to HDL cholesterol (over 5 is not good; lower means lower risk). This means that, if you have high total cholesterol but your ratio is good, your HDL number is high and that makes you better protected than someone whose HDL is low. Routine blood screenings now tend to include this important number. Homocysteine is another number that indicates your risk of inflammatory conditions affecting the brain and cardiovascular system.

Women's Health Interview, October 2010

2010-11-03T23:57:00.000-05:00

Women’s biggest health challenges tend to be related to three general areas: hormonal health (including PMS and menopause issues), pregnancy, and maintaining health as they age (bone health and avoiding chronic degenerative conditions).

Women do seem to suffer more from certain problems related to inflammatory challenges and hormonal changes. Because of their regular, or sometimes irregular hormonal cycles, there are both advantages and disadvantages compared with men; at least until menopause tends to even the field regarding heart disease, for example. Regular menstruation lowers iron stores, reducing health problems related to oxidative and microbial challenges from free radicals that can be elevated due to the actions of uncontrolled free iron. Because of this, premenopausal women tend to have lower levels of heart disease than either post-menopausal women or adult men.

Also, because of their greater reliance on three major forms of natural estrogen as a dominant hormone complex, women seem to have greater risks of getting hormonal abnormalities and elevated cancer rates related to breast, endometrial tissues, etc. There are numerous factors involved, but oxidation of estrogens into more dangerous forms has been suggested as a major contributor to those risks. The fact that certain volatile plastics containing free BPA and specific other chemicals are known to be strong estrogen mimics makes exposure to those substances very dangerous to women, in particular.

Men do share some of those risks; for example, some estrogenic agricultural chemicals widely used on lawns, golf courses, and farms (herbicides, pesticides) are suggested to elevate the risk of prostate abnormalities. But men’s consequences tend to be more subtle and drawn out than the very real risks that women face from both these exposures and lack of protective nutrients such as a range of antioxidants and detoxification aids such as silymarin, broccoli and cruciferous vegetable consumption, and various liver supporting herbs and nutrients. The regular use of NSAID anti-inflammatory drugs – often utilized for PMS and other aches and pains – is associated with side effects that similar-acting nutrients and herbs lack: negative effects include reducing availability of some important nutrients, upregulation of pain triggers, negative effects on mood, stomach and GI problems, and degenerative cascades. Bless their hearts; many women don’t have it easy.

Women who eat enough legumes, flax seeds, and other sources of plant estrogens (phytoestrogens) tend to have more manageable menstrual cycles. Certain signs, like menstrual-related migraine headaches, indicate a deficiency of adequate natural progesterone levels that can be helped either by supplying the herb Vitex (chaste berry) if premenopausal or by applying natural progesterone cream to the skin. Certain herbal formulas and isoflavones from foods are utilized to preserve healthy and more comfortable menstrual cycles.

One thing that women should do to prepare for menopause is to maintain their bone mass by exercise and getting adequate supplies of not only calcium but also vitamins C, D, and K, magnesium, boron, and other bone support nutrients. The value of an alkalinizing whole food diet is of primary importance. The presence in the diet of legumes and flax seeds eases the transition to menopause, which is a normal part of a women’s life cycle.

The existence of biofilms informs our understanding of areas where bacteria and microbes can gown in the body. The fact that certain organisms – helpful or harmful – can create a mass that is layered like chainmail to resist removal is a powerful visual image that aids in understanding why it takes so long to effect changes in our inner ecology. Ideally, we have friendly probiotic bacteria coating our GI and urinary tracts to crowd out undesirable organisms. In fact, it was recently discovered that the purpose of the appendix was to serve as a reservoir of such probiotics to help “reboot” the system in case of problems that kill off the good bacteria; of course, with antibiotics, high sugar diets, stress, and other factors lowering the vitality of our probiotics, some people will grow the nasty stuff in their appendixes, presenting a serious health risk. The ability of Candida albicans live yeast and other organisms to overgrow at undesirable levels at the expense of more beneficial probiotic microbes means that some of our layered biomass colonies are undesirable and difficult to remove quickly. D-Mannose and cranberry (blueberries, too) tend to help prevent the spread of these colonies by preventing undesirable particles from adhering to the urinary tract walls but don’t kill off existing colonies. Still, these natural substances are helpful in curtailing their spread while other strategies are implemented, such as low sugar intake or even pharmaceuticals.

To support breast health it is wise to avoid BPA plastics, don’t microwave food in plastic, don’t consume agricultural chemicals on food, eat a plant-based diet providing antioxidant-rich produce, and eat plenty of broccoli, cruciferous vegetables, and non-GMO legumes, especially soy.

Various experts warn us against eating soy, with the suggestion that plant estrogens are dangerous. I have investigated the scientific literature to determine the risk and found that the scientific consensus is that there is no risk for healthy women, and even no indication that soy foods are unsafe for women who have had breast cancer! That is amazing when you consider all of the negative theories being hyped on the Internet. Soy prevents oxidation and conversion of estrogen into its more dangerous forms, aids in liver metabolism of these hormones and various toxins, and has been “proven” to protect against heart disease (soy actually has an FDA-approved qualified health claim related to this benefit).

The Truth About Fructose Dangers

2010-11-03T23:39:00.000-05:00

Pure crystalline fructose is an alternative natural sweetener that has long been used in the natural products industry as a common sugar substitute. Its major claim to fame is that in the short term fructose raises blood sugar far less than sucrose, the primary sugar found in white sugar that is made from sugar cane or sugar beets. Crystalline fructose should not be confused with the synthesized liquid sweetener called high fructose corn syrup (HFCS), which is made by a different process and is a mixture of roughly half fructose and half glucose (dextrose) that is widely used in the beverage and processed food industries. Unlike HFCS, fructose is a naturally occurring sugar made by plant photosynthesis that is a primary sugar in many healthy fruits. Being about 50% sweeter than sucrose, fructose can also be used more sparingly in recipes to cut their caloric intake by about 1/3.

Because of the unique challenges of formulating natural products without the use of artificial sweeteners or flavorings, sometimes a small amount of fructose is the best match for the flavorings in a product. For example, liquid vitamin B-12 has a distinct flavor profile and other sweeteners do not mask it quite as well as fructose can. Often a mixture of sweeteners may be used to create a “mouth feel” that is acceptable to consumers, who often use white sugar as their sensory standard for sweeteners. While some people may intellectually prefer other sweeteners or even white sugar, in sensory tests the fructose mixture often gets higher marks from consumers, and this leads to high compliance with recommended label uses.

I appreciate the concerns over the use of fructose. It has certainly been abused in the Western diet, especially in the form of HFCS. Americans' fructose consumption on average has tripled over the past century. But increased consumption of fruit juice and sucrose itself also are implicated in our national health decline; certainly not fructose alone, nor fructose in low doses.

According to Dr. Lustig*, an authority on fructose metabolism, human studies have not consistently shown the effect of fructose to induce insulin resistance; a negative effect reported in some animal and preliminary human studies related to altered liver metabolism. Dr. Lustig also admits that not all human studies show a negative effect of fructose on liver health or metabolic syndrome. There appear to be certain individual factors involved that make such effects somewhat idiosyncratic. Many of the studies cited are cell studies, animal studies giving high doses of fructose to mutant mice, or human studies where consumption of a lot of soft drinks were involved that provided a large number of calories comprising an unhealthy proportion (25% or more) of total daily caloric intake (about 500 calories as fructose every day). Contrast this with a healthy nutritional product that provides only a few calories, a very low percent versus those unhealthy diets!

Dr. Lustig notes that "In the hypocaloric (eg, starvation) state, fructose is as beneficial as glucose"; while also noting it has ill effects in the "hypercaloric state". He also discusses how a small amount of ethanol, a substance with similar liver effects to high fructose diets, is actually health-promoting while large amounts have the opposite effect. This reinforces that the ability of substances to elicit ill effects on the liver are typically dose dependent and require larger-than-normal amounts. In effect, 'the dose makes the poison;' as has been noted for many substances throughout history.

Dr. Lustig specifically cites three what he calls "antidotes" to the negative hepatic (liver) effects of fructose:

1. reduce the amount consumed

2. exercise

3. increase fiber intake.

So, upon reviewing these facts, the consumption of a small amount of fructose is unlikely to be harmful to the general public. Additionally, consumption of reasonable amounts may also be quite harmless if the person gets enough fiber and/or exercise. And the accepted fact that fructose does not directly raise blood glucose still gives it some short term advantages over certain other sweeteners for many people, if consumed at appropriate levels. Faster acting sugars that are higher on the Glycemic Index like glucose (which represents close to half of the sugar content of HFCS) would more immediately impact one's blood sugar, with chronic overuse eventually leading to insufficient/reduced insulin sensitivity (increased insulin resistance) that is associated with a loss of blood sugar control. Higher Glycemic sugars would affect this blood glucose control system much faster than an equivalent amount of pure fructose. And a lack of insulin sensitivity also indicates a problem in properly absorbing and recycling vitamin C in many of our body's cells; especially immune, muscle, and bone cells.

There are a variety of natural sweeteners to fit into most individuals' personalized dietary regime; but I do not promote the indiscriminate use of any sweetener, especially refined or synthetic ones. People like to have choices and will select sweeteners according to their own taste and health issues. For example, some avoid barley malt because of gluten sensitivity or certain other sweeteners because of corn allergies. People on limited diets need to scrutinize the available sweeteners and select what seems right for their own situation. But it's clear that a small amount of almost any natural sweetener, say to sweeten a cup of tea, does not seem to have any demonstrable health risk. For overly large amounts, the potential risks do increase. But a demonstrated risk level typically represents consumption of several hundred calories a day of refined sugars, including fructose, and it obviously is unwise to take in most of our daily carbohydrates in the form of refined sugars of any kind.

Consumption of small amounts of pure crystalline fructose simply doesn’t have a measureable effect on health and doesn’t need to be avoided. It’s the fructose consumed in large quantities in processed foods and beverages, where it comprises perhaps the major source of carbohydrates in the modern diet, that is the real health concern.

* Lustig RH. Fructose: metabolic, hedonic, and societal parallels with ethanol. J Am Diet Assoc. 2010 Sep;110(9):1307-21. PubMed PMID: 20800122.

NHRI Symposium on Cost-Effectiveness & Safety of Dietary Supplements

2010-09-07T14:27:00.001-05:00

The NHRI (Natural Health Research Institute) is a non-profit institute dedicated to research in natural cost effective dietary supplements and natural products.

NHRI will be hosting a scientific symposium in November in the local area. Click on this link for more details:

NHRI symposium announcement

We hope that this symposium "Natural Products – Cost-Effectiveness & Safety of Dietary Supplements" will help boost awareness of the safety and cost effectiveness of dietary supplements and natural products.

Calcium & Cardiovascular Health: My review of the latest meta-analysis

2010-08-03T23:31:00.000-05:00

At the end of July (2010) there was another nasty swipe at dietary supplements (Natural Health Products, for our Canadian friends). Again, the negative report came not from a single study, but from a particularly troubling type of report called a meta-analysis. Rising like a spider on a lethal web, this type of report keeps popping out of nowhere, attempting to make connections between studies where none may have been found before. In fact, we rarely see a competently designed meta-analysis on nutrients because there are many variables that come into play that simply don’t exist for isolated pharmaceutical drugs that aren’t (or at least aren’t supposed to be) present in our normal food supply. The interplay of nutrients affects each others’ metabolism, serum levels, and activities in a live human body. So when I see yet another meta-analysis getting major press coverage based on fairly flimsy evidence, I cringe and wonder why researchers and journalists fail to see the obvious flaws in their big story. Perhaps drug researchers are trying to branch out into nutrient research and just get in over their heads because they fail to see the complexity of nutrient research design.

The alleged danger this time: supplemental calcium was associated with a 30% increased risk of myocardial infarction, so the risks now outweigh the benefits. But was this proven? NO! Absolutely not. Nada. Zilch. Even the authors of this analysis know better than to claim that their report was definitive proof of these alleged dangers.

First of all, there was no increase in deaths in the groups given supplemental calcium. There was an increase in non-fatal heart attacks; but only in people who had already high calcium intake from their diets and also took high doses of supplemental calcium that they apparently didn’t need. And there was no problem demonstrated when calcium was given along with supplemental vitamin D, so maybe the problem was really that some folks had inadequate levels of that essential vitamin to deal with a high calcium intake.

But since vitamin D is both in the diet (as is calcium) and made from sunshine under the right conditions, these meta-analysis authors don’t really know how much vitamin D these people actually had, confounding their data. They don’t know because it would have required a rigorous study design that looked at all three intakes: food, supplements, and sunlight exposure at the times of day and year where vitamin D could be internally produced. Or at least measuring the serum before treatment to detect vitamin D levels and eliminate that as a variable. But that wasn’t done, perhaps because these researchers only looked at other people’s studies rather than running a human clinical trial themselves.

This points out perhaps the major problem with this type of study: since a meta-analysis is only a statistical model that cannibalizes previously published work to “mine” data in ways that were not planned by the original study designers, it has many built-in limitations. For example, cardiovascular outcomes were admittedly not intended as the primary endpoints in any of the 15 studies ‘Mixmastered’ together to make up this meta-analysis, so data on cardiovascular events were not gathered in the usual standardized manner. In plain English: the few cherry-picked studies included in this report had not done the type of standardization and control of variables needed to properly design a robust cardiovascular study because the original studies actually were looking at calcium’s effects on bone health, not heart health. This was, in fact, an admitted limitation of the current meta-analysis.

A good meta-analysis tries to pick the largest possible number of studies with similar designs to pool their results and in effect try to get a larger, hopefully more significant number of virtual test subjects. The farther from that model the meta-analysis gets, the more variables get introduced to confound the researchers. And since control of variables is the essential competence of the scientific method, we unfortunately find that an inexpertly executed meta-analysis is a misleading and erroneous scientific tool; like a ruler that has not been calibrated correctly and implies that our measurements are accurate when they may be way off the mark.

Researchers utilizing the imprecise tool of meta-analysis should not delude themselves that their work is definitive, because it almost never is. Nor should they become media darlings because they have espoused new theories - based on an unproven brew of mathematical models - that usually are already contradicted by a lot of better designed primary science. Nor should their attempts to re-examine previously published studies for results which were never intended to be measured scare us away from taking essential nutrients, which are commonly more healthful than harmful. As the current meta-analysis reported, the problem was that people who ate a lot of calcium who also took a lot of supplemental calcium without the benefits of taking vitamin D or other bone-forming cofactors had more non-fatal heart attacks. No one died. This implies that, at the most, one should not take a single nutrient in excess as if it were a magic drug, especially when they probably already get plenty in the diet. Don’t most of us know that already?

Nutrients are synergistic; therefore an imbalanced diet, including unneeded supplements that may tilt one even more into imbalance, may not properly support good health. Heck, I could have told you that before all this media fuss. But, with enough vitamin D the problem magically disappeared!. Supplementation of vitamin D apparently re-established good calcium metabolism, even at high levels of intake. The true issue then isn’t so much related to variations in calcium and vitamin D supplies, not to mention the unknown availability of other essential bone nutrients. It’s the misapplication of a drug model to a nutrient while ignoring known variables that affect the body’s proper use of that nutrient. One shouldn’t give a lot of calcium to those with adequate dietary intake, nor to those with insufficient vitamin D (and K, magnesium, et al) intake. This type of thought process is elementary to a nutritionist, of course, but apparently not to the well credentialed authors of many flawed drug model meta-analyses and their often overreaching conclusions.

You may be interested to know that a world-class researcher who has been working on calcium metabolism and osteoporosis for more than 50 years, the respected scientist who drafted the World Health Organization’s dietary calcium recommendations, strongly opposed the conclusions of the current calcium meta-analysis. Professor Chris Nordin from the Royal Adelaide Hospital in Australia was interviewed by ABC News. This news report cited Professor Nordin as saying that the meta-analysis was misleading because it improperly included studies involving a mixture of men and women, and the findings were not statistically significant. "Men are much more liable to heart attacks than women but women need calcium far more than men, so it is absurd to publish a study of the effect of calcium on the heart without separating men from women," he was quoted. Professor Nordin noted the fact that calcium supplements are predominantly recommended for and used by postmenopausal women because their bone loss is due to an increase in bone breakdown, which responds well to calcium supplementation (and vitamin D, if necessary). But he reports that calcium is seldom recommended for elderly men because their bone loss has a different cause, which is seldom caused by a need for more of that mineral. "Concluding that calcium supplements can lead to a 30 per cent increase in heart attack risk is quite premature and alarmist and can only set back the cause of osteoporosis prevention which should be our primary objective," he said.

According to ABC News, Osteoporosis Australia has also questioned the findings of the meta-analysis because many long-term studies have shown calcium supplements are safe and effective. In a statement posted on its website, Osteoporosis Australia says the weight of evidence to date indicates no increased risk of heart attacks from taking calcium supplements, which it says are an effective way of reducing fracture risk and bone loss in older men and women who have diets low in calcium.

This should point out the folly of well-meaning researchers who design studies to investigate topics that they don’t properly understand. In those cases, they simply don’t realize that there are other essential factors that can change everything and require a completely different and more comprehensive study design. That’s par for the course when meta-analyses are used to sort through previously published nutrient studies. Basic design flaws often make meta-analyses fatally flawed, despite the apparently sophisticated mathematical models and methods that researchers incorrectly try to apply to the data. Is it any wonder that we’re so confused about nutrition when researchers gain worldwide prominence for issuing highly questionable sensational reports that contradict the scientific consensus - but never have to say they’re sorry?

Calcium does not cause more heart attacks in well-designed primary human clinical studies. Healthy people should not be concerned about taking essential nutrients just because certain studies were flawed or performed on sick or at-risk populations and may have had negative results. Many of those negative reports have been challenged and may not have been verified and replicated in well designed clinical trails. The conclusions of such reports are sensational and well publicized precisely because they seem to negate our previous scientific consensus; which should make them more, not less, suspect. But the modern news cycle seems to thrive on such controversy, without caring how confused we get about what’s healthy and what’s not. But don’t worry; you have Honest Nutrition to help you sort it all out!

REFERENCES:

Bolland MJ, Avenell A, Baron JA, Grey A, Maclennan GS, Gamble GD, Reid IR. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ. 2010 Jul 29;341:c3691. doi: 10.1136/bmj.c3691. PubMed PMID: 20671013.

http://www.bmj.com/cgi/content/full/341/jul29_1/c3691?view=long&pmid=20671013

http://www.abc.net.au/news/stories/2010/08/03/2972399.htm?section=justin

My report on regulation of health claims

2010-07-23T11:10:00.000-05:00

On April 24, 2010, I was asked as a representative of the American Nutrition Association to participate in a panel discussion at the annual conference in Chicago called Health Journalism 2010, held by the Association of Health Care Journalists. The panelists presented short statements and slides, then answered audience questions. This is a link to my report and slides from that event:

http://americannutritionassociation.org/newsletter/assessing-claims-functional-foods-nutritional-supplements

Dietary Supplements are now Safely Regulated

2010-07-23T09:51:00.002-05:00

TIMELINE:

1994 The Dietary Supplement Health and Education Act (DSHEA)

• Requires manufacturers to follow Good Manufacturing Practices (GMP) set by the FDA

     o GMPs were fully implemented between June 2008 and June 2010

• Continues to define dietary supplements as Food

• Regulates labels

     o All claims must be truthful and not misleading

     o All ingredients must be on the labels

     o Documentation to prove claims must be maintained

• Approves pre-existing dietary ingredients already on the market as of October 15, 1994

     o Common vitamins, minerals, herbs

     o “Grandfathering” was twice applied to pharmaceuticals already on the market:

     o The 1938 Food, Drug and Cosmetic Act & 1962 Kefauver-Harris Amendments

• Requires pre-market submission to the FDA of all New Dietary Ingredients marketed after October 15, 1994

     o The agency questions the majority of submissions

     o The agency has the power to reject applications; and has done so

     o This is analogous to pharmaceuticals where all drugs entering the market after October 10, 1962 require an FDA submission/approval process

1997 Food and Drug Administration Modernization Act (FDAMA)

• Provides for health claims based on an authoritative statement by a scientific body of the U.S. government or the National Academy of Sciences

• Such claims may be used only after submission of a health claim notification to FDA

2002 The Public Health Security and Bioterrorism Preparedness and Response Act

• All food manufacturers, including dietary supplement manufacturers, are required to be registered with the government and give advance notification of raw materials imports

2003 The FDA Consumer Health Information for Better Nutrition Initiative

• Provides for qualified health claims where the quality and strength of the scientific evidence falls below that required for FDA to issue an authorizing regulation

     o Such health claims must be qualified to assure accuracy and non-misleading presentation to consumers

2004 The Anabolic Steroid Control Act amendment

• Bans steroid precursors sold as dietary supplements

     o The FDA and DEA have authority to take action against adulterated products

2006 The Dietary Supplement and Nonprescription Drug Consumer Protection Act

• Requires reporting of all serious adverse events (AERs) for both dietary supplements and OTC drugs

The Food Allergen Labeling and Consumer Protection Act

• Requires label disclosure of the 8 major allergens that cause 90% of all food allergies

2010 The most recent annual report of the American Association of Poison Control Centers

• Published in the journal Clinical Toxicology

• Reports zero reports of accidental deaths from dietary supplements

     Full implementation of mandatory federal cGMPs was completed in June

• All manufacturers & suppliers are now bound by FDA standards of safety and documentation

     The Dietary Supplement Full Implementation and Enforcement Act

• Introduced in Congress to increase funding for FDA enforcement of dietary supplement laws

     The Food Safety bill

• Includes enhanced mandatory recall authority for all foods, including dietary supplements

• Expected to pass Congress soon

How proteins are digested to liberate amino acids

2010-07-20T15:19:00.001-05:00

Digestion is obtained by actions of stomach acid (low pH) and enzymes both in the stomach & intestines (pancreatic protease). In the acidic environment of the stomach, the negatively charged side chains are removed by pepsin. In the more alkaline environment of the intestine, the positively charged side chains are removed by trypsin. In the stomach, Pepsin helps to "unwind" the proteins and breaks the bonds between the amino acids in certain places. In the small intestine other enzymes break the bonds between different amino acids than pepsin does. Because proteins are such complicated molecules it takes a long time and more than one enzyme to completely break them down into amino acids. Digestion results in about 60% small peptides (or peptide bound), which are longer chains of amino acids, and 40% free amino acids (free form). Peptides can be further broken down by hydrolysis in enterocytes (intestinal absorptive cells, simple columnar epithelial cells found in the small intestines and colon).

All proteins are naturally hydrolyzed by stomach acid during normal digestion and the amounts in mineral chelates are in milligram, not gram, strengths. Fermentation to make healthy foods like cheese, vinegar, yogurt, miso, etc. also digests proteins and liberates amino acids, which are of course essential to human nutrition.

Although the excitatory amino acids aspartic acid and glutamic acid are not essential amino acids, the body can create them from numerous sources. In fact, glutamine is the major circulating amino acid and the brain will break down muscles to get it for fuel if the blood sugar is too low to support brain function. Glutamine also fuels some intestinal cells.

Sports Supplements Are Regulated

2010-07-14T13:25:00.001-05:00

To the editor (Times Herald-Record, Hudson Valley, New York state):

Your special report, “Supplements for athletes stir serious debate” (June 29, 2010) is interesting but presents some misleading ideas.

For example, the quote that “18.8 percent of supplements are tainted with steroids or other illegal, potentially dangerous ingredients” is seriously flawed, since the percentage actually refers to 240 sports supplements tested, a tiny fraction of the tens of thousands of dietary supplements on the market. These products were actually tested 9 years ago when steroid precursors were legal; spiking them with steroids was always illegal. Today, thanks in part to the dietary supplement industry lobbying for a federal ban on steroid precursors, that product category is dead and this inflammatory quote does not reflect the present market. If any illegal drug is present in a product it is defined by law as an unapproved drug, not a dietary supplement, subject to FDA and DEA enforcement.

Regarding Senator McCain’s bill to more strictly regulate supplements: I met with him after the bill was introduced to present the inconsistencies between the actual bill and how he described it. Under the anti-bioterrorism bill of 2003 all dietary supplement manufacturers are already required to register with the FDA; as do all domestic or foreign food manufacturers selling in the US. Under several federal laws all ingredients already must be on dietary supplement labels. Failure to do so makes the products adulterated and subject to a range of FDA actions. His bill would actually have subjected each new product introduction to prior FDA approval, expanding the federal bureaucracy and amounting to a government takeover of the entire dietary supplement industry. Importing this Canadian-style regulatory scheme would duplicate that system’s failures: half as many products on the Canadian market, products considered safe in the US are effectively banned, waits of over 4 years to introduce variations of existing products, higher prices, etc.

Your series promises to disclose how the dietary supplement industry “is opposed to regulations.” That is absolute nonsense! The dietary supplement industry has long supported new laws and regulations that are reasonable, with these already in place: all vitamin companies must follow FDA-audited Good Manufacturing Practices requiring safety and identity testing, only FDA-approved ingredients can be used, steroid precursors are banned, and companies must disclose all complaints of adverse events requiring medical attention to the FDA within 15 days. The dietary supplement industry supports increased government authority to mandate product recalls in the Food Safety Bill. But the American people won’t stand for a major expansion of government power that gives bureaucrats absolute veto authority over each new consumer product, stifling innovation. That’s not only anti-capitalism, it’s un-American.

Original story
http://www.recordonline.com/apps/pbcs.dll/article?AID=/20100629/SPORTS/6290316/-1/SPORTS

This reply published:
http://www.recordonline.com/apps/pbcs.dll/article?AID=/20100709/OPINION/7090312

Reference:
http://multimedia.olympic.org/pdf/en_report_324.pdf

Still Fighting to Protect Our Access to Vitamins!

2010-06-24T14:36:00.001-05:00

Over the last week or two, a joint House-Senate conference committee has been considering ways to reconcile two competing federal Wall Street reform bills and turn them into a single bill that both chambers can support. The US House’s Wall Street Reform and Consumer Protection Act of 2009 (HR.4173) and the US Senate’s Restoring American Financial Stability Act of 2010 (S.3217) differ in cost and content, most notably for us in that the Senate version does not give the broad new regulatory powers to the Federal Trade Commission (FTC) that the House version would. By removing limits on its power that are enshrined in current laws, the FTC could impose harsh new requirements on all businesses, even those completely unrelated to Wall Street, banking, or the financial sector; including NOW Foods and other food and dietary supplement manufacturers.

How do we expect that the FTC would act if given such new power? The agency has indicated that it wants to impose stricter standards on any advertising of dietary supplements. Past consent decrees that settled disputes with supplement companies have required strong disclaimers and much more evidence to support any future promotional claims. Consumer advocate organizations have urged the agency to require that multiple clinical trails be done on any advertised product, not just on its ingredients, to support advertising claims. However, such trials take many months, are very expensive, and are not required by current law allowing claims to be based on the body of science backing the active ingredients in a product. If the FTC and anti-business consumer advocates have their way, label claims and advertising will be far more restricted than is presently allowed. Of course, ads already have to be truthful and not misleading, so that’s not really an issue. But the FTC still wants more power so it can unilaterally impose a new regulatory scheme that bypasses today’s requirements for hearings, public comments, and due process before it can change the rules that we operate under.

Do you support another government takeover of an American industry? But this time, for an industry that is not hurting or asking for federal bailouts? One whose products are overwhelmingly proven in the real world to be safe and that helps Americans to maintain good health? Do you believe in freedom of speech for commercial interests like vitamin makers, as long as their ads continue to be honest and not misleading? If so, we are fighting to be protected from a big federal power grab.

Take action now to tell your Senators and Representative in Congress that you want to continue to impose Congress’ reasonable limits on the FTC, rather than expanding its powers. Go to http://www.csofh.org/ to learn how to Take Action and express your concerns!

Following is a list of the people on the joint Congressional committee deciding how the bill will be reconciled. They have the most immediate say on how the reconciled bill will read. However, all Senators and representatives will be asked to vote on the final reconciled bill, so it doesn't hurt to ask them to tell the negotiators to pull the FTC provision out of the bill even if they're not on the joint committee!

House of Representative members on Conference Committee: Frank (D-Massachusetts); Kanjorski (D-Pennsylvania); Waters (D California); Maloney (D-New York), Gutierrez (D-Illinois); Watt (D-North Carolina); Meeks (D-New York); Moore (D-Kansas); Kilroy (D-Ohio) and Peters (D-Michigan); Bachus (R-Alabama); Barton (R-Texas); Graves (R-Missouri); Issa (D-California); Lucas (R- Oklahoma); Smith (R-Texas); Royce (R-California); Biggert (R-Illinois); Capito (R-West Virginia); Hensarling (R-Texas) and Garrett (R-New Jersey).

Senate conferees: Dodd (D-Connecticut); Shelby (R-Alabama); Johnson (D-South Dakota); Reed (D-Rhode Island); Schumer (D-New York); Corker (R-Tennessee); Crapo (R-Idaho); and Gregg (R-New Hampshire). Also appointed as negotiators are Senators Lincoln (D-Arkansas); Chambliss (R-Georgia); Leahy (D-Vermont); and Harkin (D-Iowa).

Excerpts from an iterview with me about natural sweeteners

2010-05-27T15:49:00.000-05:00

A whole leaf, full spectrum extraction of stevia preserves the many phytonutrients naturally present in the plant. One study reported over 100 natural stevia phytonutrients; the majority being polyphenols and other plant antioxidants. By contrast, there are about 9 steviosides. But the new “Reb A” fraction products being sold as food sweeteners (PureVia™, Truvia™) represent only a single chemical isolated from the stevia plant, though these two sweeteners are actually sold with added sugar alcohol (Erythritol, see below) and “natural flavors”.

Some artificial sweeteners cannot be used in cooking; for example, aspartame. By contrast, natural sweeteners typically do not lose their sweetness when cooked. And studies have indicated that artificial sweeteners may backfire by shutting down the satiety signals that tell us when we’re full…in those studies the groups fed artificial sweeteners ate up to 3 times the calories as control groups.

Sugar alcohols don’t raise blood sugar as rapidly as sugar does, yet they’re as bulky as sugar so they can be used “spoon - for - spoon” to replace sugar. But their level of sweetness may vary, with xylitol being the closest to sugar. Sugar alcohols have a range of sweetness and absorption; the amount that is absorbed from the GI tract affects the possibility of it being somewhat laxative at high levels, which can vary from person to person. Sorbitol may be laxative at moderate levels of 10 grams or more, mannitol at over 20 grams; xylitol at over 30 grams. Erythritol is virtually free of a laxative side affect even at higher levels, but is expensive. Also, sugar alcohols tend to have a cooling effect in the mouth and actually taste better when combined with a different type of sweetener.

Sugar alcohols also boast an FDA-approved health claim: “Frequent between-meal consumption of foods high in sugars and starches promotes tooth decay. The sugar alcohols in [name of food] do not promote tooth decay.”

I think that organic maple syrup, agave and xylitol are doing quite well as natural sweeteners, with erythritol a more recent option that is catching up. The recent crossover of a certain isolated fraction of stevia (Reb A) as a mass market sweetener has some drawbacks: it doesn’t taste like whole leaf extract, and is combined with both erythritol and natural flavors. And there are certified organic full spectrum extractions without the typical bitter aftertaste or added flavoring agents.

Many stevia products are still only legal to sell as herbal dietary supplements, not as sweeteners. Some companies may think that all stevia products are now approved for use in foods, but that is not true. Retailers should take their cues from the packaging, and only carry reputable brands that strictly follow labeling laws. It is primarily the isolated “Reb A” fraction of stevia that can be used in foods. Most other stevias have not been approved for food use, with some exceptions.

Excerpts from my interview about nutrition and diabetes

2010-05-27T15:19:00.001-05:00

Fasting blood sugar tests are how doctors have long checked patients for blood sugar issues. A person’s options are greatest when they first discover that their blood sugar has gone out of balance. If they wait until after they’re on insulin or other medications, any natural means for improvement in blood sugar control could cause a dose of medicine to become an overdose. It is very important that your physician knows if you are going to try to control your blood sugar naturally, and that you test your blood sugar levels every time before taking medication in order to avoid dangerous interactions.

It normally takes several years to progress to full diabetes, and many people make diet and lifestyle changes that can control their blood sugar and prevent the development of diabetes without the use of drugs. But prolonged pre-diabetes weakens the system, being inflammatory and unsustainable over the long term. Of course, progression to full-blown diabetes is the biggest risk; meaning medications for the rest of your life, circulatory problems that can lead to blindness, neuropathy and amputations, more risks from infections, inflammatory problems, and even premature death. Adjustments to medications are needed and there is the possibility of insulin shock or diabetic comas. Frequent urination, high blood pressure, even the elevated risk of heart attack and stroke are other serious issues that diabetics face.

It’s a positive development that more people address health conditions when they first have indications of a growing problem. This may be partly because of high health care costs, but many people are motivated to improve their health for its own sake.

Metabolic Syndrome is a pre-diabetes condition defined as a combination of three or more of these symptoms: waist circumference over 40” for men and over 38” for women, high blood sugar (defined as a fasting blood glucose level over 100 mg/dL), high triglycerides (over 150 mg/dL), low high-density lipoprotein (HDL, the "good" cholesterol, levels below 40 mm Hg for men and under 50 for women), and hypertension (high blood pressure; the top number (systolic) over 130 and/or the bottom number (diastolic) over 85). Medical treatment for one or more of these symptoms is also considered a risk factor. Metabolic Syndrome increases belly fat and is a step on the path towards developing adult-onset diabetes. Low blood sugar (hypoglycemia) may be a symptom of yo-yo blood sugar regulation, a loss of control that could develop into pre-diabetes and diabetes.

There are a number of factors, but lifestyle choices are controllable, whereas a genetic predisposition is not. Most gene expression, the way that genetics actually plays out in real life, responds to environmental factors. For the gene itself, nutrients are part of its environment that trigger or suppress specific genetic responses.

Dr. Thomas A. Barringer of Carolinas Medical Center in Charlotte, North Carolina reports that his studies show that multiple vitamins benefit our diabetic population. He states that “any population at risk of having marginally inadequate nutrition, such as the elderly in general, might also benefit." Dr Barringer adds: “all obese people might benefit." He pointed out that supplements are safe and relatively inexpensive, so taking a daily multivitamin is "a reasonable option" for people who are overweight, who have any type of diabetes, who may not receive adequate nutrition or whose immune system is weak. (March 4th 2003 Annals of Internal Medicine)

Take a good multiple vitamin with a fat-containing meal in order to absorb the fat soluble nutrients. If you take green foods or other nutritionally dense dietary supplements, take them with a meal to help increase the total nutritional value of that meal.

Alpha Lipoic Acid (ALA) is a potent antioxidant that reduces insulin resistance. Insulin resistance occurs from swings in blood sugar from poor diets high in refined carbohydrates (white flour, white sugar, high fructose corn syrup) that eventually lead to the hormone Insulin becoming ineffective at moving carbohydrates out of the bloodstream into the cells. ALA has the additional benefit of protecting cells from oxidative damage, including liver cells.

Chromium is available in several forms. While much of the current evidence is on the form called chromium picolinate, other forms may be gentler and more active in controlling cholesterol, such as chromium nicotinate that’s bonded to niacin (Vitamin B-3). This mineral helps us to properly manage blood sugar and is a component of Glucose Tolerance Factor. Chromium may also help maintain lean body mass (muscle) during calorie-restricted dieting.

Citrin® helps to limit the liver's production of fat from carbohydrate.

GlucoFit® is a source of corosolic acid for proper insulin sensitivity to allow sugars to be moved from the bloodstream into cells.

Gymnema sylvestre improves uptake of glucose into cells, may block ability to taste “sweet” and may be useful for maintaining healthy cholesterol and triglyceride levels

HCA (-Hydroxycitric acid) is an extract from the fruit rind of Garcinia cambogia may reduce the body’s ability to convert carbohydrates into stored fats.

Stevia extract is a natural herbal product that is non-caloric, may support pancreatic function and promote insulin sensitivity.

Agave Nectar Dangers; facts and myths

2010-04-19T09:10:00.000-05:00

The people claiming that fructose is worse than sucrose are ignorant and plain wrong. HFCS is typically 42% fructose, mostly glucose; some is 55% fructose.

Is blood sugar no longer an important issue? Diabetes statistics would seem to insist that it is still relevant. In that regard alone, fructose (with a Glycemic Index rating of 20, versus 100 for 100% sucrose white sugar) is far better than sucrose in terms of not provoking high blood sugar and the resulting insulin reactions.

And the repetition that agave nectar production is analogous to HFCS production is mind numbingly simplistic and misleading. In terms of agave production, taking inulin that's made of chains of fructose, adding non-GMO "plant enzymes" to free the fructose, then heating and filtering is not really that unnatural a process; in fact, in some ways quite similar to human digestion. HFCS production involves converting 100% sucrose corn syrup into fructose and then adding pure corn syrup to achieve the 42% or 55% fructose syrup (the rest of the 100% in each form is pure corn syrup as sucrose). There is no corn used to make agave nectar, and sugars are not converted into other forms or blended.

Studies showing that getting 25% of daily calories, around 500 calories, solely from fructose is related to obesity begs the question of why getting nearly all of our carbs from a single sugar, rather than from a mix of sugars along with fiber and starches, is anything other than a fast food worst case scenario. This is not relevant to those taking a little agave nectar in place of other sweeteners. Trying to frighten people who now won't even take a piece of whole fruit or a couple of calories worth of fructose in a chewable or liquid dietary supplement (this is actually happening!) is in my opinion both cynical and misleading. That is not honest nutrition. Common sense should be more common.

To My Canadian friends and colleagues

2010-04-13T23:19:00.000-05:00

Thanks for your hospitality last week while I was in Edmonton, Calgary and Winnipeg. Everyone was very friendly and courteous. I appreciate your being willing to share your time with me and to discuss nutritional issues.

If any of you will be in Vancouver at Expo West in May, please come see me on Friday morning for the organic program http://honestnutrition.blogspot.com/2010/04/neil-to-speak-at-organic-program-in.html
and also at the Puresource booth. I look forward to seeing you!

Neil to be on radio in Las Vegas, also streaming live on Internet

2010-04-13T23:13:00.000-05:00

Monday, April 19, 2010

8 am Pacific, 10 am Central time

KLAV 1230AM

Neil to speak at organic program in Vancouver, BC

2010-04-13T23:08:00.000-05:00

Canadian Health Food Association's Expo West trade show

Expo West, Organic Program, Friday, May 14th, 10:30 am – Noon

PLAYING WITH OUR FOOD: NUTRIENT DIFFERENCES OF ORGANIC, CONVENTIONAL AND BIOTECH (GMO) CROPS

By Neil E. Levin, CCN, DANLA

The method by which similar types of crops are grown - organic, conventional or genetically engineered (GE, biotech, GMO) – can produce food with different nutritional profiles. Are organics really no more nutritious than conventionally grown crops? Do currently grown biotech foods really provide more nutrients than similar types of conventional foods? What do we know about the heavy metal content of foods grown by different methods? Are USDA food nutrient tables even accurate in this era of changing agricultural practices? Learn the secrets of how our foods are changing, for better or for worse.

http://www.chfa.ca/LinkClick.aspx?fileticket=FGY6Nxakm%2bc%3d&tabid=399&language=en-US

Neil to Speak to Health Journalists: Assessing claims of functional foods and nutritional supplements

2010-04-13T23:01:00.000-05:00

The Association of Health Care Journalists meeting in Chicago on April 24, 2010

"Health Journalism 2010"
Program: "Assessing claims of functional foods and nutritional supplements"

Panel:
• Neil E. Levin, C.C.N., D.A.N.L.A., programs chair, American Nutrition Association; nutrition education manager, NOW Foods

• Marilynn Marchione, medical writer, The Associated Press

• Bruce Silverglade, legal director, Center for Science in the Public Interest

• Moderator: Bianca Alexander, chief executive officer, Conscious Planet Media

Neil will be giving a presentation in the Oak Park, Illinois area on 4/28/2010

2010-04-13T22:52:00.000-05:00

Less of You to Love: A Nutritionist's Secrets for Successful Weight Management

Lecture presented by Neil E. Levin, CCN, DANLA

•Principles for gradual & sustainable natural weight loss

•What to eat: Including the one essential metabolism boosting component of every meal

•When to eat: How often and how many meals a day

•How to eat: Conscious eating and digestive tips

Wednesday, April 28th - 7:00pm Meet & Greet, Lecture 7:30pm

LOCATION: Concordia University, Christopher Center, 7400 Augusta St., River Forest, IL 60305

Call 708.246.FOOD (3663) or email Contact@AmericanNutritionAssociation.org for tickets

Admission $20 - Free for ANA Members & Concordia Students / Employees

http://americannutritionassociation.org/upcomingevents

Lecture presented by the American Nutrition Association® with the cooperation of Concordia University

Risk factors in developing Type 2 (adult-onset) diabetes

2010-04-04T17:29:00.000-05:00

Improper diet and lack of exercise are major risk factors in developing Type 2 (adult-onset) diabetes. Prolonged stress and too high proportions of carbohydrates (carbs) in the diet also contribute to blood sugar problems. The problem carbs are excess levels of sugars – especially simple sugars - and starches. Complex carbs from vegetables, whole fruits, whole grains and beans are used to fuel brain activity and other body functions without excessively elevating our blood sugar. Fiber content will also help the ability of food to make us feel full. Fiber also helps to slow the introduction of other carbohydrates into the bloodstream, reducing blood sugar “peaks” after a meal. Another bonus of whole foods is that fiber can absorb cholesterol-containing bile salts, a key way to dump excess cholesterol from the body.

Eating a diet composed largely of processed/refined foods means that the carb level is probably too high while nutrients that help us to deal with blood sugar (B vitamins, fiber, chromium, etc.) are stripped from our food supply. This leaves us defenseless against weight gain, abdominal obesity, high blood pressure, high blood sugar and elevated stress hormones.

Many of us are literally drowning in excess empty calories that affect our metabolism. But skipping meals doesn’t help, nor does eating meals that lack adequate protein. Both habits discourage calorie burning.

Spikes in blood sugar are the main enemy of dieters and those with blood sugar control issues. Elevated blood sugar triggers the release of the hormone insulin, which can cause low blood sugar (hypoglycemia), which makes us fatigued after a meal. If this happens too often it can create insulin resistance, eventually causing a loss of blood sugar control that can result in Metabolic Syndrome. This is a pre-diabetes condition defined as a combination of two or more of these symptoms: insulin resistance, glucose intolerance, abnormally high insulin levels, high triglycerides, low high-density lipoprotein (the "good" cholesterol), and hypertension (high blood pressure). Metabolic Syndrome increases belly fat and is a step towards developing adult-onset diabetes.

Your options are greatest when you first discover that your blood sugar has gone out of balance. If you wait until after you're on insulin or other medications, any natural means for improvement in blood sugar control could cause a dose of medicine to become an overdose. It is very important that your physician knows if you are going to try to control your blood sugar naturally, and that you test your blood sugar levels every time before taking medication in order to avoid dangerous interactions.

Going on a low-carbohydrate (low-carb) diet is the next step. The worst carbs are the simple sugars, found in processed foods, sweets, table sugar and soda pop. Processed grains and starchy vegetables are sometimes a problem, especially in excess. Flours (especially white flour) are more of a problem than whole cooked or sprouted grains. Even carrot juice is high in sugar!

If you tend to have weight gain and blood sugar problems in middle age, the good news is that you are genetically programmed to survive a famine. The bad news is that it's a prolonged feast which can kill you! Portion control and exercise are important for your health. Controlling stress will also help your sugar balance.

The balance of nutritional components within a meal regulates fat storage and fat burning. Try to balance each meal using the ZONE diet, where at least 30% of the calories in every meal are from protein, about 30% from healthy fats and about 40% from complex carbohydrates such as whole grains, fruits or vegetables. This balance will minimize blood sugar increases. Blood sugar spikes can lead to more fat storage and less fat burning, especially without enough protein to start the calorie burning cycle after a meal.

To improve the insulin response that moves sugar out of the blood and into cells for fuel instead of turning into fat, supplements of Omega-3 fish oil (or flax oil for vegetarians), Alpha Lipoic Acid and Chromium may be helpful. Phase 2®, from a white kidney bean extract, will block some digestion of starches to sugar and therefore effectively lower your carb and calorie intake. Antioxidants of all kinds are very protective for people having blood sugar issues.

Take a good multiple vitamin with a fat-containing meal to enhance absorption of the fat-soluble nutrients. If you take green foods or other nutritionally dense dietary supplements, also take them with a meal to help increase the total nutritional value of that meal.

In Defense of Natural Foods: Fish Oils

2010-03-03T11:25:00.000-06:00

In Defense of Natural Foods

By Neil E. Levin, CCN, DANLA

A public debate is now raging over the safety of natural fish oils. In truth, though, this should be more properly recognized as a narrowly focused legal debate rather than representing any real question as to whether these natural food products are good for us to eat; because health authorities around the world have already acknowledged that it is generally better to eat natural fish and fish oils than to avoid them. Yet a quirk in California law makes it possible for some environmental lawyers to argue that the general scientific and medical consensus on the known health benefits of natural fish products be ignored; instead touting zero tolerance for pollutants that are widespread in our food supply and advocating that only highly processed oils be sold.

I am certainly not in favor of pollutants; my bona fides are clear. As a student I led environmental classes in my school on the first Earth Day on April 22, 1970 and have broken whole grain bread with the late Earth Day founder Senator Gaylord Nelson at a natural food Thanksgiving dinner. I spent a day with Al Gore at a solar symposium that he hosted in Tennessee in the late 1970’s. My wife and I live on a 4-acre wooded hillside that is a National Wildlife Federation Certified Wildlife Habitat™. We have recycled, grown and bought organic food, used primarily natural and biodegradable products in our home, politically and financially supported several environmental groups, and otherwise have been ardent environmentalists for some 40 years. I’ve worked in the natural food industry for my entire adult life and am so into it that I became a clinical nutritionist who reads complex nutrition studies for kicks. So when I question other environmentalists for creating a public panic that may turn people off from eating foods that provide scientifically demonstrated health benefits despite the possibility of tiny amounts of pollutants being in them, it may merit some attention.

The attorneys argue that only highly processed fish oils are acceptable; all other fish oil products should have label warnings that they may contain parts-per-billion (ppb) amounts of PCBs, a banned industrial chemical that is still so widespread in the environment that the native people of the far north have it in their bodies from the wild fish that is the base of their traditional diet.

According to the Food and Drug Administration (FDA), “Small amounts of PCBs can be found in almost all outdoor and indoor air, soil, sediments, surface water, and animals. However, PCB levels have generally decreased since PCB production stopped in 1977. People are exposed to PCBs primarily from contaminated food and breathing contaminated air. The major dietary sources of PCBs are fish (especially sportfish that were caught in contaminated lakes or rivers), meat, and dairy products.”

What are the health impacts of PCBs? That is really hard to say. Most negative reports are from rodent studies, where the animals are fed huge amounts for long periods. The FDA reports that, “PCBs are not known to cause birth defects,” and has no cases on record, so that concern seems unfounded, despite the claims of the current private lawsuit. The agency does report that PCBs are probable carcinogens based on such animal studies and cases of industrial workers exposed to substantial amounts of the chemicals. It also reports developmental problems in children of mothers exposed to “high” amounts, but not specifically birth defects and not at significantly harmful levels. “Some studies have estimated that an infant who is breast fed for 6 months may accumulate in this period 6–12% of the total PCBs that will accumulate during its lifetime. However, in most cases, the benefits of breast-feeding outweigh any risks from exposure to PCBs in mother’s milk.”

Fortunately, the FDA has also estimated that the amount of PCBs in food is steadily declining since the chemicals were banned. Between 1978 and 1991, the estimated daily intake of PCBs in adults from dietary sources declined by about 62%. “Meat and dairy products are other important sources of PCBs in food, with PCB levels in meat and dairy products usually ranging from less than 1 part in a billion parts (ppb) of food to a few ppb.” That means a Quarter Pound burger weighing about 113 grams could lawfully contain hundreds of nanograms (billionths of a gram, or parts-per-billion) of PCBs, approaching about half a microgram (a microgram is one-millionth of a gram, or one part-per-million). If you got somewhat less from a natural fish oil, plus enjoyed the added cardiovascular benefits of the essential Omega-3 fatty acids it provides versus the known cardiovascular risks of beef and other animal fats, should that really be a great concern, especially when heart disease is blamed for about half the deaths in this country?

The official Health Canada federal agency reports that, “Exposure to these low levels does not appear to affect human health. Based on recent results from Total Diet Studies (a series of studies organized by Health Canada), the average daily dietary intake of PCBs is thought to be less than half of one microgram (one microgram = one-millionth of a gram). People who eat large amounts of sports fish, wildlife or marine mammals may be exposed to higher dietary levels of PCBs…Media reports have raised concerns about PCBs in farmed salmon. Health Canada and the Canadian Food Inspection Agency recently completed a survey of farmed and wild fish. The survey analyzed a large number of samples for PCBs. The results showed that eating salmon from the commercial food supply (whether farmed or wild) does not pose a health risk to consumers.”

The UK Food Standards Agency has reported that the health benefits of eating moderate amounts of fish, including salmon, as part of a healthy balanced diet outweighed any potential risk from PCBs. Based on 21 surveys carried out by the Agency results found that exposure to these contaminants from the diet has fallen by about 75% between 1982 and 1997.

How has the U.S. federal government determined safe levels of PCBs in foods? “The FDA has set residue limits for PCBs in various foods to protect from harmful health effects. FDA required limits include 0.2 parts of PCBs per million parts (ppm) in infant and junior foods, 0.3 ppm in eggs, 1.5 ppm in milk and other dairy products (fat basis), 2 ppm in fish and shellfish (edible portions), and 3 ppm in poultry and red meat (fat basis).” Two ppm in fish is equivalent to 2,000 ppb (parts-per-billion) in fish. The fish oil products in question today contain less as a percentage by weight than is allowed even in baby food, and are taken in far smaller amounts by total weight per serving than whole fish. Yet these fish oils are now being targeted for added label warnings that they are known by the state of California to contain toxins with the false implication that these minute dietary amounts are proved to be harmful and should be avoided at all costs.

What are the alternatives? Apparently eating actual fish won’t do; they would be consumed at far larger serving weights and naturally contain far more PCBs than a serving of natural fish oil. Yes, some fish oils are highly purified, which is what the lawyers argue as a reasonable alternative to the natural oils. Yet there are legitimate critics who argue against chemically processing and refining natural food products such as this, even for reasons of purity. And some of the oils most likely to have accumulated PCBs are from long-lived fish which are higher in the ocean food chain and have been long valued as health foods with strong evidence of enhancing human health, like cod liver and salmon oils.

If we force all foods to either have disproportionally scary warnings or be processed out of their natural states, pushing only the least natural products as the “best” choices, this has serious implications for the nature of our food supply and how it impacts our nutritional status. We have seen degenerative disease rates soar as the amount of refined foods in the diet increases, and natural food advocates have long argued that we return to unrefined whole foods in order to naturally maintain health. This current fish oil scare is capable of needlessly frightening people away from taking safe healthy fish oils that could improve their health. That would be the real crime.

References:

Agency for Toxic Substances and Disease Registry (ATSDR). 2000. Toxicological profile for Polychlorinated Biphenyls (PCBs). Atlanta, GA: U.S. Department of Health and Human Services, Public Health Service. http://www.atsdr.cdc.gov/toxprofiles/phs17.html

Health Canada http://www.enotalone.com/article/10328.html

The UK Food Standards Agency

Vitamins Are FDA-Regulated

2010-03-02T09:46:00.000-06:00

Contrary to popular myth and The Healthy Skeptic (LA Times 3/1/10), the federal FDA (Food and Drug Administration) already regulates dietary supplements such as vitamins, minerals and herbs. These are NOT “unregulated” products. What actually makes critics’ teeth grind is the fact that vitamin formulas do not need specific pre-approval from the federal regulators, which is the true endgame of many skeptics. But all ingredients used in nutritional supplements before mid-October of 1994 are already pre-approved by the FDA under an often-misrepresented law called DSHEA, which also requires all new dietary ingredients to be submitted to the FDA for pre-market review before a product is sold. This gives the agency a chance to review the required submission of safety and efficacy data before any new ingredient can be sold, and the power to veto its introduction.

Dietary supplement manufacturers are already required to submit label claims along with scientific documentation to the FDA, but are paradoxically required to use a label disclaimer that the agency has not evaluated the formula. Vitamin makers are already registered with the government, are already prohibited from making medical/drug claims for dietary supplements, and are already required to identity-test and list all ingredients on product labels. A recent adverse event reporting law promptly lets the FDA know of virtually any problem requiring medical attention in order to trigger recalls and new label warnings. Under DSHEA, the FDA can regulate the manufacture of all dietary supplements, an oversight that was dramatically improved over the past 3 years with the rollout of mandatory Good Manufacturing Practices. Obviously, this is not an “unregulated” industry, even if enforcement can be improved in some areas.

Advocates of pre-approval of dietary supplement formulas want to import a highly flawed and controversial Canadian health care program in a misguided effort to give our own unelected government bureaucrats absolute power over already-regulated vitamin products. Many Canadians now cross the border to buy American supplements because their own government arbitrarily delays entry of new products for years at a time, miserly approving only 42% of products that have been submitted with all of the required safety and efficacy documentation. This is not a free market model, does not work well, and is not worth copying.

A permanent government takeover will strangle a preventive health industry that, in America’s free market, has added jobs and exports during our recent recession. Vitamins help Americans meet basic nutritional needs in a cost-effective manner without government funding; and probably decreased some Medicare spending, according to the conclusions of authoritative Lewin Group reports. There is a complex regulatory structure for vitamins and other dietary supplements in the U.S. that is working quite well; there were ZERO deaths officially reported from these products last year even though about 2/3 of Americans use them. Claims that “vitamins are unregulated” are woefully inaccurate and should not be published by news outlets with competent fact checkers.

http://www.latimes.com/features/health/la-he-0301-skeptic-20100301,0,2486837.story

Neil was interviewed about CoQ10 for a trade magazine

2010-02-25T13:33:00.003-06:00

* How would you rate consumer awareness of the health benefits of CoQ10? Neil: There is actually a fair amount of consistently positive press on CoEnzyme Q10 (CoQ10), with a significant part of that because of this antioxidant nutrient’s role in cardiovascular and heart health. Many cardiologists recommend CoQ10 to their patients and popular books, such as by Dr. Sinatra, promote the healthful effects of CoQ10 to at-risk people. I would go so far as to suggest that CoQ10 has picked up some of the wide popularity as a heart nutrient that vitamin E had several years ago (but lost due to consumer confusion caused by unwarranted negative publicity). The fact that CoQ10 is so obviously safe, versatile, and useful has propelled it to a high place on the list of cardiovascular nutrients. * What is driving consumer interest in CoQ10 products? Neil: The multiple roles of CoQ10 in the human body make it uniquely useful in protecting cells and energizing essential processes such as heart action and immunity. Energy supports the constant pumping of the heart muscle, but also supports immune functions and antioxidant activity. Lack of energy is a common complaint heard by doctors, and active people need good sources of energy, so nutrients that promise to improve the energetics of the body are always in demand. In addition, new technologies to improve the historically poor absorption of CoQ10 have expanded the product category as prices have moderated, which is a perfect place for people selling CoQ10 to be in. Tell us more about CoQ10: Neil: Ubiquinol doubles as an antioxidant, and like other antioxidants the body can convert from one to the other and back again. Although Ubiquinol lacks much in the way of human clinical trials, supplemental Ubiquinone mostly converts to Ubiquinol during transport from the gut to the circulatory system. Ubiquinol is the primary form of the nutrient that circulates in the body. Ubiquinol converts to Ubiquinone to stimulate the production of cellular energy. CoQ10 is a fat-soluble nutrient and therefore should only be taken with meals containing significant amounts of fat. That has traditionally been the main limiting factor in absorption. Blending CoQ10 into an oily base to make softgel capsules is somewhat superior to dry capsules because a little oil is provided, but again there just isn’t enough oil in a capsule to make a big difference when the nutrient is not dissolved into the oil. When CoQ10 is completely dissolved into an oil, forming a crystal-free solution, it does make it several times more absorbable. But all oily solvents are not created equal! Some manufacturers use the synthetic chemical polysorbate 80 as the base and main ingredient in the softgel capsule, whereas others use only natural citrus or coconut oil fractions to do the same job because we prefer to have natural bases.

My response to Bill O’Reilly’s program “Suzanne Somers' 'No Spin' on Vitamins”

2010-02-25T13:24:00.002-06:00

,On Friday, February 19, 2010, Bill O’Reilly discussed recent legislation introduced by Arizona Senator John McCain (the Dietary Supplement Safety Act; S.3002) to impose new regulations on dietary supplements (vitamins, etc.) with Suzanne Somers. He made several points that are quite reasonable: that there should be warnings on labels, that we should know what is in the products, that manufacturers should be registered with the FDA, that ingredients should be disclosed, and that the FDA should have recall authority. I heartily agree with these common sense statements but need to point out that these elements are already mandated by current federal regulations that simply may be inadequately enforced. As in other fields, a few shady operators ignore laws when profits can be made by cheating. The answer to the occasional scofflaw is strict enforcement of existing law; without enforcement, both current and new laws would be equally worthless. But Mr. McCain’s proposed new law will severely decimate law-abiding companies in a misguided effort to import an unpopular regulatory scheme from Canada that gives unelected government bureaucrats absolute power over already-regulated vitamin products. Canadians now cross the border to buy American vitamins because their own government arbitrarily delays entry of new products for years at a time, miserly approving only 42% of products that have been submitted with all the required safety and efficacy documentation. Current laws can accomplish Mr. O’Reilly’s goals, if they are enforced. Dietary supplement manufacturers are already registered with the government, are already required to submit label claims to the FDA, are already prohibited from making medical claims for dietary supplements, and are already required to identity-test and list all ingredients on product labels. Ingredients that have been on the market for many years are already pre-approved by the FDA and all new ingredients must be specially pre-approved before going to market. All mislabeled products are considered adulterated and subject to mandatory recall. A recent adverse event reporting law promptly lets the FDA know of virtually any problem requiring medical attention in order to trigger recalls and new label warnings, This does not sound like an unregulated industry, even if enforcement can be improved in some areas. What we don’t want is the FDA, an agency that is cozy with pharmaceutical interests, to have complete power over every new vitamin formula that is merely a variation of already-approved ingredients. That kind of permanent government takeover will strangle an important health industry that in a free market added jobs and exports during the recession. Vitamins help Americans meet basic nutritional needs in a cost-effective manner without government funding and may have actually decreased some Medicare spending, according to the conclusions of authoritative Lewin Group reports. Understand and enforce the current laws before proposing a virtual federal takeover of an industry that is law-abiding, has welcomed recent regulations that have empowered federal authority over it, and would suffer great harm from a huge increase in unnecessary government interference. Think about it: If you were driving on the highway at 55 miles per hour and occasionally some jerk speeds by at 90, would dropping the speed limit to 45 correct the problem? Of course not. It obviously makes more sense to station additional cops along that stretch of highway to enforce current traffic laws than to collectively punish all drivers. Why is enforcement of vitamin laws any different? Target the outlaws, not the innocent! Neil E. Levin, CCN, DANLA www.honestnutrition.com

NATURAL and ALTERNATIVE SWEETENERS

2009-11-30T10:41:00.001-06:00

Some artificial sweeteners cannot be used in cooking; for example, aspartame. By contrast, natural sweeteners typically do not lose their sweetness when cooked. And studies have indicated that artificial sweeteners may backfire by shutting down the satiety signals that tell us when we’re full…in those studies the groups fed artificial sweeteners ate up to 3 times the calories as control groups. Sugar alcohols don’t raise blood sugar as rapidly as sugar does, yet they’re as bulky as sugar so they can be used “spoon - for - spoon” to replace sugar. But their level of sweetness may vary, with xylitol being the closest to sugar. Sugar alcohols have a range of sweetness and absorption; the amount that is absorbed from the GI tract affects the possibility of it being somewhat laxative at high levels, which can vary from person to person. Sorbitol may be laxative at moderate levels of 10 grams or more, mannitol at over 20 grams; xylitol at over 30 grams. Erythritol is virtually free of a laxative side affect even at higher levels, but is expensive. Also, sugar alcohols tend to have a cooling effect in the mouth and actually taste better when combined with a different type of sweetener. Sugar alcohols also boast an FDA-approved health claim: “Frequent between-meal consumption of foods high in sugars and starches promotes tooth decay. The sugar alcohols in [name of food] do not promote tooth decay.” A whole leaf, full spectrum extraction of Stevia should preserve the many phytonutrients naturally present in the plant. One study reported over 100 natural Stevia phytonutrients; the majority being polyphenols and other plant antioxidants. By contrast, there are about 9 steviosides. And the new Reb A fraction products being sold as food sweeteners are only a single chemical isolated from the stevia plant. There is a bitter aftertaste associated with traditional Stevia products. Some mix Stevia with sugar alcohols like erythritol in order for the sweetener to mask the bitter aftertaste. The recent crossover of a certain isolated fraction of Stevia (Reb A) as a mass market sweetener has some drawbacks: it doesn’t taste like either whole leaf or other traditional Stevia extracts, and is combined with both erythritol and natural flavors. Many stevia products are still only legal to sell as herbal dietary supplements, not as sweeteners. Some companies may think that all stevia products are now approved for use in foods, but that is not true. Retailers should take their cues from the packaging, and only carry reputable brands that strictly follow labeling laws. It is primarily the isolated “Reb A” fraction of stevia that can be used in foods. Most other stevias have not been approved for food use. There is a wide selection of natural/alternative sweeteners: Organic Agave Nectar, Barley Malt powder, Organic Brown Rice Syrup (some have no gluten [usually barley malt] added; some do), Beet Sugar (for those with cane allergies), Date Sugar (look for pure dried date pieces with no oat flour added), Dextrose, Fructose, Lactose, Organic Maple Syrup, Organic Sucanat®, and Organic Turbinado Sugar.

Boston Globe wrong on Vitamins, Supplements

2009-11-09T00:58:00.002-06:00

Dietary Supplements Are Regulated In its Nov. 2 editorial, the Globe complained that the FDA is “powerless” to police dietary supplements and called for a repeal of the Dietary Supplement Health and Education Act of 1994. Health and Education Act of 1994. I suggest that the editors read the law and see what it is that they would lose by doing so. Mandatory Good Manufacturing Practices (GMP) were authorized by this law. GMPs control the manufacturing of all supplements, requiring quality controls, identity and safety testing. Federal GMPs are currently being implemented. No one in their right mind wants this to go away right when it is just getting started. Federal pre-approval of all new dietary ingredients (NDIs) is also required by DSHEA. Isn’t that close to what the editors suggest when they want pre-market approval of all new supplements? Adulterated products are already banned by this law. And steroids and steroid precursors are specifically banned under another more recent law that was supported by the dietary supplement industry. DSHEA bans misbranded products, such as those containing hidden drugs, and offers them absolutely no protection. In fact, the misbranded products that the editors complained about are actually defined as unlabeled drugs by the FDA, not as dietary supplements, so technically DSHEA does not even apply to them. Let’s leave out the evildoers who deliberately hide illegal drugs in bottles misbranded as dietary supplements. What does that leave us with? The vast majority of dietary supplement companies responsibly follow the law and do not have poor quality products. There are rarely cases of serious injuries or deaths from dietary supplements when you take away the products that are really illegal drugs made by outlaws who don’t care about the law or their own customers’ health. Responsible brands follow the new FDA dietary supplement GMPs, checking all ingredients for identity and purity and looking for contaminants and known adulterants. They truthfully declare all ingredients and correct dosages on the labels. They monitor product usage for adverse events and report serious ones to the FDA when they occur. They are not the criminals counterfeiting illegal drugs disguised as dietary supplements. What part of this cries out for such severe regulation that pre-market approval of new formulas is needed? How will new laws stop lawbreakers when their actions are already clearly illegal? Pre-market approval in Canada is a joke; many ingredients and formulas are not available there even though American citizens freely enjoy their use without serious issues. Some American manufacturers have already pulled out of the Canadian market, while others offer only small selections of their lines because of the bureaucratic hoop jumping required for government approval. If DSHEA is repealed, many safe legal products providing much-needed nutrients will disappear while the lawbreakers continue to do business, with a net harm to public health. http://www.boston.com/bostonglobe/editorial_opinion/editorials/articles/2009/11/02/police_these_pills_and_powders/

How Nutrition Affects Swine Flu (Influenza) and Immunity

2009-10-27T13:36:00.003-05:00

Why are the Public Health authorities silent on the role of nutrition to protect us during an official national health emergency? Do they not know, or simply not care? Is either answer acceptable to citizens concerned about their health and wanting to get practical/real/fair/impartial information that we can utilize to help protect our families? Here's what the experts are not telling us:

Did you know that if you had the seasonal flu vaccine last year it may make you more vulnerable to the swine flu this year? Vaccines create antibodies that actually make you more susceptible to other organisms, like viruses and bacteria. (Four Canadian studies reported by CBC News, 9/23/09)
Did you know that side effects of vaccines can be minimized if there are adequate levels of vitamin D in the person? (Epidemic influenza and vitamin D. Epidemiol Infect. 2006 Dec;134(6):1129-40. Review.)
Did you know that a lack of vitamin D makes people far more likely to have respiratory infections? (On the epidemiology of influenza. Virol J. 2008 Feb 25;5:29. Review.) Did you know that the virus itself can become less aggressive and less prone to mutating into more dangerous forms if a person has adequate levels of nutrients, especially antioxidants? (Host nutritional status: the neglected virulence factor. Trends Microbiol. 2004 Sep;12(9):417-23. Review.)
Did you know that antioxidants, like selenium, not only reduce our vulnerability to getting influenza but also reduce the chances that it will progress into pneumonia! (Host nutritional status: the neglected virulence factor. Trends Microbiol. 2004 Sep;12(9):417-23. Review.)

Nutrition, Eye Health & Diseases of Aging Eyes

2009-10-12T09:43:00.004-05:00

Glaucoma is pressure in the eyes and can be from different causes such as narrow/inflamed tear duct drainage or a type of high blood pressure type problem. Since synthetic prostaglandin eye drops (travatan, etc) are sometimes used to maintain normal pressure, it implies that natural prostaglandins (GLA, fish oil) might prevent certain forms of glaucoma. Cataracts and macular degeneration are caused by oxidative damage. http://www.ncbi.nlm.nih.gov/pubmed/17478338?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum Lutein is the key but not sole antioxidant. It does take about 5 grams of fat to absorb 10 milligrams of lutein (usually found in a complex also containing zeaxanthin), so lutein only absorbs well if taken with a meal. Eye formulas are also very good to supply multiple antioxidants and eye nutrients. These should also be taken with meals. Lutein is also the yellow pigment in egg whites, dark green leafy vegetables, yellow corn, orange peppers and squash. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=9828775

Glutamine, MSG & excitotoxins, and protective nutrients

2009-09-09T09:15:00.001-05:00

Clinicians giving several grams a day of pure L-Glutamine do not report excitotoxic reactions. The main one is for the synthetic chemical MSG. Sometimes people react to fermented foods, which indicates a problem in containment and nutritional status. Vitamin C removes glutamate from the neurons, which are additionally protected by antioxidants (tocotrienols, tocopherols, et al) and by magnesium. Branched-chain amino acids help to compartmentalize glutamates. Glutamine is fine with other aminos; the main competition is between the arginine pathway aminos (arginine, ornithine, and lysine); with another noted competition to get through the Blood Brain Barrier between the Large Neutral Amino Acids: aromatic aminos (tyrosine, phenylalanine, and tryptophan) and the BCAAs (leucine, isoleucine, and valine).

How are vitamins C, D and K in supplements made?

2009-09-09T09:08:00.004-05:00

Almost all D’s on the market are nature-identical synthesized forms. D3 and D2 are both naturally occurring in foods, but in supplements the same forms are usually from synthesized sources. So D3 synthesized from sheep lanolin is no more natural than D2 from plants or fungi. In fact, the D3 made in the skin-liver-kidneys from cholesterol and sunlight is also literally synthesized. Either plant sterols or animal sterols (cholesterol in humans, lanolin from sheep) are irradiated with UV-B light to make D2 or D3, respectively. It is a synthetic process, either internally or to produce the supplemental form; in much the same way that vitamin C can be synthesized by most mammals (not humans) from blood glucose in a process that mirrors the commercially synthesized nature-identical form. By the way, Vitamin K is also synthesized as the exact same form found in green foods (K1). Fermented foods like cheese can also contain K2 (MK-4), which is synthesized by microbes like bacteria.

Mislabeled Vegan Supplements?

2009-08-10T22:37:00.007-05:00

It appears that some vitamin brands are listing their products as Vegan, yet formulating them with vitamin D3 synthesized from Sheep's Lanolin. There is no Vegan source of vitamin D3, which is produced by chemical synthesis when animal fats called sterols are exposed to Ultraviolet light (UVB rays). D3, or cholecalciferol, is always made from animal fat. The other form, vitamin D2, or ergocalciferol, is from a Vegan source; though one has to watch out for animal gelatin stabilizers and microbeads in microencapsulated dry forms, especially. Vegan microencapsulation for dry forms of fat-soluble nutrients including beta-carotene and lutein was only perfected in mid-2005, so it is possible that some products made before then were mislabeled as Vegetarian if the company did not investigate its raw material sources carefully. (Many brands do not manufacture their own vitamin supplements, relying on contract manufacturers to make their outsourced formulas for them. In many cases, the brands do not normally have access to the full ingredient and finished product specifications of the actual manufacturer. This can lead to ignorance and errors when making label claims related to the presence or absence of allergens and animal products.) The D2 form is synthesized from plant sterols exposed to the same kind of light. Plant sterols, by the way, have an FDA-approved health claim that they "may reduce the risk of heart disease" and are considered healthy. http://www.fda.gov/Food/GuidanceComplianceRegulatoryInformation/GuidanceDocuments/FoodLabelingNutrition/FoodLabelingGuide/ucm064919.htm There is also a controversy over whether D3 is much better than D2. D3 is the form found in fish liver oils and is often added to fortify foods such as milk and orange juice. D3 is also the form that we synthesize in our own bodies when cholesterol (that animal sterol aforementioned) is exposed to UVB rays. D2 is likewise made by plants when their oils (plant sterols, or phytosterols) are exposed to UVB light. In modern studies, both forms are equally well absorbed and both are good at preventing rickets and maintaining bone mass. Both forms equally maintain the level of the active compound serum 25(OH)D3 levels. "Therefore, vitamin D2 is equally as effective as vitamin D3 in maintaining 25-hydroxyvitamin D status." http://www.sciencedaily.com/releases/2008/01/080102122306.htm It appears that D3 tests better than D2 in an occasional dosing schedule, like if you got it once a month from a doctor's office. But the assay is apparently flawed and is now known to not measure D2 very well, underestimating its circulating level. For everyday supplementation and fortification, both forms work equally well by all current measures. Some brands with "cultured" or "fermented" ingredients apparently believe that adding lanolin-sourced vitamin D3 to a yeast culture, then drying the whole thing and using it to make vitamins, somehow transmutes the animal fat form of the vitamin into a Vegan-friendly ingredient. They say that the yeast consumes the lanolin-derived vitamin and that the yeast is Vegan no matter what it is fed. But they present no evidence that yeast consumes vitamin D or changes it in any way. Quite the contrary; they brag about providing vitamin D3 – a known animal product - in a supposedly Vegan supplement. This indicates that they know that the form is not changed in any significant way by the yeast culture. One major brand, when asked by me only today, said that they do not disclose their D3 source for their vitamin labeled as Vegan because the source is both "irrelevant" and "proprietary". In other words, they won't tell us and we don't need to know. That pisses me off, pardon me for taking this apparent contempt for Vegans personally. I am not a Vegan but have been a vegetarian since 1972. I do not eat any type of flesh; avoiding not only all forms of meat but also animal broths, gelatin and leather. I scrutinize labels to assure that I am getting no animal products except for dairy, eggs, and honey. Now the Honest Nutritionist in me wants to sound the alarm that some companies are using animal products like gelatin and lanolin in their Vegan-claimed dietary supplements. Whether it's an honest (though sloppy) mistake or a deliberate attempt to have their cake and eat it too is hard to say for sure, but either way this is not fair to Vegans. I tend to fear the worst since they claim the supposedly superior and more popular D3 form in a product whose label also appeals to Vegans and Vegetarians who are being led to erroneously believe that there is now a Vegan-friendly source of D3. There isn't. It is just not true. We are being misled. D3 is not Vegan. D2 is, and is not a bad form as some try to claim. Some medical experts even want to routinely fortify the food supply with D3 because of the largely mythical superiority of that form; that would deprive all Vegetarians and Vegans of their right to avoid hidden animal products in our food. I believe that we have a fundamental right to select our diets based on individual religious, ethical, and cultural beliefs. It is wrong for a corporation to take that right away from us by incorrectly labeling their products that are marketed to Vegetarians and marked as Vegan. Mislabeled products are considered to be adulterated. Obviously, there is no safety issue here and it does not seem as if this matter has attracted much attention, as of yet. But these jokers have attracted my attention and I think that they deserve to get grassroots attention to their attempt to sell non-Vegetarian products to Vegetarians and Vegans. I am not naming names here but will not buy products made by any companies which suggest that animal-source D3 can ethically be sold to Vegans. If you are of the Vegetarian or Vegan persuasion, please check your product labels. If I see vitamin D3 in a product labeled as Vegetarian, I’d feel free to return it to the store as a mislabeled product and get my money back. Vote with your dollars and read product labels carefully before buying anything. If enough people do this, the companies with questionable products will have to deal with a lot of returns from unhappy customers and stores, combined with a drop in sales. Eventually, they will be forced to either correct their labels or change their formulas.

Vioxx withdrawn

2009-08-06T08:34:00.003-05:00

ARTHRITIS DRUG WITHDRAWN, PEOPLE ARE LOOKING FOR ALTERNATIVES By Neil E. Levin, CCN, DANLA A major pharmaceutical company has announced a worldwide recall of its top arthritis drug due to cardiovascular problems seen in long-term users. Merck has withdrawn Vioxx from the market after a study was halted because users of the drug had 200% as much risk of getting heart attacks than participants taking a placebo. Medical experts are advising patients taking Vioxx to consult with their physicians about a substitute. If you are one of these people, there is no better time than now to discussthe use of natural alternatives to drugs with your doctor. If you can get temporary relief of aches and pains by using natural herbs and foods with minimal side effects rather than with more dangerous prescription drugs, why not? After all, dangerous side effects are one reason why drugs have restrictions on their sale in the first place. You have three basic choices to inhibit inflammation. Here they are, one at a time: PRESCRIPTION COX-2 INHIBITORS COX-2 Inhibitors help to prevent inflammation from developing by blocking the action of a certain chemical called COX-2. These drugs are noted for reducing "risk of clinically important GI (gastrointestinal) events" by some 50-60% versus non-steroidal anti-inflammatory drugs like aspirin and ibuprofen. However, most of the COX-2 Inhibitor drugs are also associated with an increased risk of cardiovascular problems. And there are still a goodly number of GI complaints in the COX-2 groups. Now one of the most prominent COX-2 inhibitor drugs has been pulled off the market for doubling the rate of heart attacks. Over-The-Counter NSAIDs (non-steroidal anti-inflammatory drugs) Doctors reportedly recommend NSAIDs, which are COX inhibitor drugs like aspirin and ibuprofen, more than they prescribe COX-2 inhibitor drugs like Celebrex and Vioxx. But there are also problems with NSAIDs. Gideon Bosker, MD, Assistant Clinical Professor at Yale University School of Medicine, reports on the use of NSAIDs for Osteoarthritis (OA) and Rheumatoid Arthritis (RA): "As every primary care practitioner knows, NSAID-associated GI toxicity has become a public health problem, especially among older patients with OA and RA. Gastrointestinal intolerance has been reported in up to 50% of patients on long-term NSAIDs. "NSAIDs cause irritations in the gastrointestinal tract, leading to bleeding and iron loss. (Bjarnason I, Macpherson AJ. Intestinal toxicity of non-steroidalanti-inflammatory drugs. Pharmacol Ther 1994;62:145-57) Going off drugs like aspirin and ibuprofen often causes a rebound effect that creates a cascade of inflammation in the Cox and Lox enzyme pathways. In one report the levels of these inflammatory markers was over 500% higher even two weeks after going off aspirin and ibuprofen! (Endres S. Oral aspirin and ibuprofen increase cytokin-induced synthesis of IL-1 beta and of tumour necrosis factor-alpha ex vivo. Immunology 1996;87(2): 264-270) Ibuprofen has caused kidney dysfunction and water retention. (Threlkeld DS, ed. Central Nervous System Drugs, Nonsteroidal Anti-Inflammatory Agents, Facts and Comparisons Drug Information. St. Louis,MO: Mar 1993, 251j-1l) There are about 16,000 deaths a year from NSAIDs, and 100,000 people hospitalized with serious complications. NSAIDs are blamed for over half of all liver failures in this country. These serious side effects have caused a demand for the COX-2 inhibitor drugs, which do not inhibit the COX-1 enzyme like some NSAIDs do. Two recent large studies (called CLASS and VIGOR) looked at the relative safety of NSAIDs versus COX-2 drugs. NSAIDs were shown to be associated with significantly more upper G.I. tract complications, including ulcers and bleeding. Partly because of such studies, COX-2 drugs have become a major success story for pharmaceutical companies over the past few years, becoming a multi-billion dollar a year business. Research published in the British Medical Journal found that 21% of adults with asthma are sensitive to aspirin. Aspirin may trigger a deadly reaction; as may ibuprofen, diclofenac and naproxen. The doctors recommend new warning labels on all products containing these drugs. DIETARY SUPPLEMENTS There are dietary supplements that may help control the inflammation associated with osteoarthritis. In some cases these will block the inflammatory COX-2 enzyme while not blocking the beneficial COX-1 enzyme. Some of these supplements will also block the 5-LOX inflammatory enzyme that is not blocked by many of the arthritis symptom relief drugs. SAMe (S-Adenosylmethionine) has been studied for depression, arthritis, and a host of other ills. Pronounced "Sam-ee", this substance was deemed effective enough to be studied in comparison to the COX-2 Inhibitor drug celecoxib (Celebrex), reportedly the least dangerous COX-2 drug in terms of cardiovascular risks. In this study 61 patients were enrolled in a randomized, double-blind, cross-over trial over a 4-month period. The researchers found that "SAMe is equivalent in almost all measures to COX-2 inhibitors (celecoxib) in relieving pain and improving function in subjects with osteoarthritis of the knee." Their functional parameters included depression, pain, impairment of physical activity and knee mobility and strength. The anti-inflammatory effects of aspirin and other drugs can also be achieved more safely with concentrated blends of spices and herbs that have a wide range of benefits. These formulas will block the COX-2 enzyme, which triggers inflammation in tissues as a response to chemical signals. NSAIDs block not only the inflammatory enzyme COX-2, but also the beneficial enzyme COX-1. The natural ingredients do not have this problem, because they block only the inflammatory enzymes. These natural ingredients will prevent the actions of not only the COX-2 inflammatory enzyme, but also of the 5-LOX inflammatory enzyme that the drugs do not usually affect. Look for an herbal formula that uses ingredients that have been shown to be helpful for inflammation and joint health, and also promoting normal cell growth (preventing abnormal growth). It should contain highly concentrated common spices like ginger and turmeric, which have been naturally extracted to contain the therapeutic chemicals in the plants. Other ingredients that will enhance an herbal formula are holy basil, EGCg-rich green tea extract, Boswellia, the antioxidant resveratrol and the enzyme bromelain (which helps digest damaged tissues so the inflammation can subside and you can rebuild). The herbs also serve as antioxidants and mild anticoagulants (bloodthinners). RELATIVE SAFETY The tremendous safety difference between dietary supplements and drugs is staggering. There are over 100,000 deaths a year from drugs versus a handful from all dietary supplements, which are far safer than any other category offered. Our risk of dying from eating dinner is far greater than from taking any dietary supplement. originally published September 30, 2004

Advice on Diet for Cancer Survivors

2009-07-09T10:45:00.004-05:00

avoid all animal proteins, they trigger cancer cell activity (esp. the milk protein: casein)
organic diet
plant based diet
no microwaving, esp. in plastics!!!
fish oil (molecularly distilled)
mixed carotenoids (vs. beta-carotene) from food or supplements
medicinal mushrooms (the common white button and portabella mushrooms will not hurt but won't help)
low temp saunas for detoxification

Nature's Own Synthetic Vitamins

2009-07-06T14:48:00.007-05:00

Yes, Nature does produce vitamins by chemical synthesis; and thus these are literally "synthetic" vitamins: "Carotenoids are colorful fat-soluble pigments that are synthesized in nature by photosynthetic microorganisms." Components of variation in serum carotenoid concentrations: the Polyp Prevention Trial M R Forman, C B Borkowf, M M Cantwell, S Steck, A Schatzkin, P S Albert and E Lanza Eur J Clin Nutr 63: 763-770; advance online publication, April 16, 2008; doi:10.1038/ejcn.2008.26

HonestNutrition.com Google Search rankings

2009-06-29T09:17:00.001-05:00

Results 5 of about 25,600,000 for pitfalls of meta-analyses Google NZ Results 2 of about 180,000 for swine flu and nutritional supplements Google Results 8 of about 48,500 for plu code organic gm Google Results 4 of about 600,000 for l-taurine vs taurine Google Results 1 - of about 958,000 for 5 milligram is what microgram Google

Bias Against Natural Products

2009-06-09T15:06:00.003-05:00

Bias Against Natural Products By Neil E. Levin, CCN, DANLA www.honestnutrition.com June 8, 2009 Once again, a widely distributed article has savagely attacked the safety and efficacy of natural products; including vitamins, minerals, and herbs. That this article may be more commentary than journalism is immediately revealed by the author inexplicably linking energy medicine (with admitted health benefits for patients) with a concocted image of “shooing evil spirits”, even when performed by technicians in a top trauma hospital. The ignorance of journalists and medical experts is exposed when they claim that natural products are intended as cures and treatments. These products are actually prohibited by law from claiming this; allowed only documented claims to support healthy body structures and functions. Ironically, this is the same law – the Dietary Supplement Health and Education Act, DSHEA - that is falsely mischaracterized as “deregulation” of the industry. In fact, this law prohibits new ingredients without FDA pre-approval; empowers the agency to regulate manufacturing, advertising, and label claims; prohibits unsafe, adulterated, and mislabeled products; and even allows banning a product based on only theoretical risks. A recent companion law requires all serious adverse events be reported to the FDA; generating far fewer reports than expected. The erroneous assumption that dietary supplements should be considered as potential treatments or cures has resulted in many negative reports. One problem is that some medical researchers, perhaps too used to drug studies using novel substances, sometimes base reports mainly on supplementation levels but fail to properly understand or explain other relevant variables such as dietary intake and relationships to other nutrients that affect body levels and functions of the targeted nutrient. The synergies of natural substances in the diet are complex and interactive, but many researchers design simplistic studies that generate incomplete or misleading data; often leading to dramatic conclusions that the pharmaceutical advertising-dependent press eats up. A press that fails to investigate and present all of the relevant facts and perspectives in a sensational negative report may be accused of laziness, if not bias. Rigorous studies refuting negative reports about the safety of vitamin E, beta-carotene, herbs, the use of supplements with cancer treatments, and drug-nutrient interactions have been noticeably absent from the same media that eagerly broadcasts reports attacking nature’s own nourishing substances. Sadly, there is no matching eagerness to set the record straight. Let’s keep this in perspective. We have all seen drugs pulled from the market because of unforeseen safety issues, medical schools and authors of articles published in peer-reviewed journals accused of being on the take from pharmaceutical companies, contaminated drugs as well as hundreds of thousands of deaths and millions of hospitalizations caused by pharmaceutical side effects each year. Foods cause hundreds of deaths and millions of illnesses annually. Compare this to dietary supplement safety, where proven deaths are extremely rare. Supplement users believe in the healing power of nature, at odds with the often unproven treatments of conventional medicine. The goal of Integrative Medicine is putting aside traditional institutional medical bias to allow science to dictate the comprehensive treatment of an individual patient, including quality of life issues. Many millions of Americans choose to use natural products in order to protect and improve their own health and vitality. Reasonable people will reject these sensational assaults on natural health (including dietary supplements), recognizing that conventional medicine sometimes fails without a little help from Mother Nature. References: Cancer patients may very well tolerate the use of certain dietary supplements http://caonline.amcancersoc.org/cgi/eletters/55/5/319#176 The truth about Vitamin E - Vitamin E is safer than implied http://www.bmj.com/cgi/eletters/330/7490/0-f#99008 Scientists to discuss benefits of vitamin E http://www.nutraingredients-usa.com/Research/Scientists-to-discuss-benefits-of-vitamin-E Vitamin review offers balanced perspective to recent negative findings http://www.worldhealth.net/news/vitamin_review_offers_balanced_perspecti Antioxidant supplements - myth or misunderstood? http://www.nutraingredients.com/Research/Antioxidant-supplements-myth-or-misunderstood Prominent Nutritionist Sets The Record Straight http://www.the-health-gazette.com/health-gazette-blog/nutrition/prominent-nutritionist-sets-the-record-straight FDA regulation of dietary supplements is sufficient http://www.journalgazette.net/apps/pbcs.dll/article?AID=/20090131/EDIT09/301319890/-1/AP05 Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Block KI, Koch AC, Mead MN, Tothy PK, Newman RA, Gyllenhaal C. Cancer Treat Rev. 2007 Aug;33(5):407-18. Epub 2007 Mar 23. Review. PMID: 17367938 Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Simone CB 2nd, Simone NL, Simone V, Simone CB. Altern Ther Health Med. 2007 Jan-Feb;13(1):22-8. Review. PMID: 17283738 Should patients undergoing chemotherapy and radiotherapy be prescribed antioxidants? Moss RW. Integr Cancer Ther. 2006 Mar;5(1):63-82. Review. PMID: 16484715 Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity. Prasad KN. Integr Cancer Ther. 2004 Dec;3(4):310-22. Review. PMID: 15523102 The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: a systematic review for a National Institutes of Health state-of-the-science conference. Huang HY, Caballero B, Chang S, Alberg AJ, Semba RD, Schneyer CR, Wilson RF, Cheng TY, Vassy J, Prokopowicz G, Barnes GJ 2nd, Bass EB. Ann Intern Med. 2006 Sep 5;145(5):372-85. Epub 2006 Jul 31. Review. PMID: 16880453 Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Margaret E Wright, Karla A Lawson, Stephanie J Weinstein, Pirjo Pietinen, Philip R Taylor, Jarmo Virtamo and Demetrius Albanes. American Journal of Clinical Nutrition, Vol. 84, No. 5, 1200-1207, November 2006. (Researchers were from the Nutritional Epidemiology and the Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, and the Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, and the Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland) Vitamins E and C are safe across a broad range of intakes. John N Hathcock, et al. REVIEW ARTICLE: American Journal of Clinical Nutrition, Vol. 81, No. 4, 736-745, April 2005. Potential for interactions between dietary supplements and prescription medications. Sood A, Sood R, Brinker FJ, Mann R, Loehrer LL, Wahner-Roedler DL; (Mayo Clinic). Am J Med. 2008 Mar;121(3):207-11. PMID: 18328304 Acute adverse effects of radiation therapy and local recurrence in relation to dietary and plasma beta carotene and alpha tocopherol in head and neck cancer patients. Meyer F, Bairati I, Jobin E, Gélinas M, Fortin A, Nabid A, Têtu B. Nutr Cancer. 2007;59(1):29-35. PMID: 17927499 Interaction between antioxidant vitamin supplementation and cigarette smoking during radiation therapy in relation to long-term effects on recurrence and mortality: a randomized trial among head and neck cancer patients. Meyer F, Bairati I, Fortin A, Gélinas M, Nabid A, Brochet F, Têtu B. Int J Cancer. 2008 Apr 1;122(7):1679-83. PMID: 18059031 The total antioxidant capacity of the diet is an independent predictor of plasma beta-carotene. Valtueña S, et al. Eur J Clin Nutr. 2007 Jan;61(1):69-76. Epub 2006 Jul 12. PMID: 16835597 [Supported by the European Community IST-2001–33204 'Healthy Market', the Italian Ministry of University and Research COFIN 2001 and the National Research Council CU01.00923.CT26 research projects.] No influence of beta carotene on oxidative DNA damage in male smokers. van Poppel G, Poulsen H, Loft S, Verhagen H. J Natl Cancer Inst. 1995 Feb 15;87(4):310-1. PMID: 7707423 Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. Hennekens CH, Buring JE, Manson JE, et al. N Engl J Med. 1996 May 2;334(18):1145-9. PMID: 8602179 Lee IM, Cook NR, Manson JE, Buring JE, Hennekens CH. Beta-carotene supplementation and incidence of cancer and cardiovascular disease: the Women's Health Study. J Natl Cancer Inst. 1999 Dec 15;91(24):2102-6. PMID: 10601381 The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994 Apr 14;330(15):1029-35. PMID: 8127329 Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers. Wright ME, et al. Am J Epidemiol. 2004 Jul 1;160(1):68-76. PMID: 15229119 Plasma carotene and alpha-tocopherol in relation to 10-y all-cause and cause-specific mortality in European elderly: the Survey in Europe on Nutrition and the Elderly, a Concerted Action (SENECA). Buijsse B, et al. Am J Clin Nutr. 2005 Oct;82(4):879-86. PMID: 16210720 Effect of multivitamin and mineral supplementation on episodes of infection in nursing home residents: a randomized, placebo-controlled study. Liu BA, et al. J Am Geriatr Soc. 2007 Jan;55(1):35-42. Erratum in: J Am Geriatr Soc. 2007 Mar;55(3):478. PMID: 17233683 Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. Blot WI, Li IY, Taylor PR, et al. J Natl Cancer Inst 1993:8ı:1483-92 Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia. Li JY, Taylor PR, et al. J Natl Cancer Inst. 1993 Sep 15;85(18):1492-8. PMID: 8360932 The Linxian trials: mortality rates by vitamin-mineral intervention group. Blot WI, et al. Am J Clin Nutr. 1995 Dec;62(6 Suppl):1424S-1426S. PMID: 7495242 Vitamins for Chronic Disease Prevention in Adults: clinical applications. Fairfield KM, Fletcher RH. JAMA. 2002;287:3127-3129.) Food-related illness and death in the United States. Mead PS, et al. Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25. Review. PMID: 10511517 American Association of Poison Control Centers annual reports FROM THE CENTERS FOR DISEASE CONTROL AND PREVENTION: Unintentional Poisoning Deaths—United States, 1999-2004. JAMA, March 28, 2007; 297: 1309 - 1311. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. Lazarou J, Pomeranz BH, Corey PN. JAMA. 1998 Apr 15;279(15):1200-5. PMID: 9555760 Washington Post reported in its 7/21/06 edition on an Institute of Medicine study released a day earlier on the toll of improperly prescribed drugs. http://www.youtube.com/watch?v=qxAR7waukVc

Nutrients of interest to stroke victims

2009-05-17T19:53:00.004-05:00

Sorry there's not much detail but this is a list that I made of nutrients that may be useful for someone who has had a stroke. I would suggest that you look each one up at a reputable online database, if interested. Of course, there are often difficulties at getting stroke survivors to take nutritional pills/caps; everything from swallowing to drug interactions. In no particular order: Vinpocetine Pycnogenol Nattokinase Rosemary Thyme Proline CoQ10 Phosphatidyl Choline Acetyl-l-carnitine vitamin E (all 8 tocopherols and tocotrienols) alpha-lipoic acid silymarin magnesium acetylcholine precursors: choline, PC, B5, huperzine

Acid-Alkaline Food Chart

2009-05-04T16:46:00.006-05:00

This chart comes from Russell Jaffe, MD, and he retains all rights.

Prepared by Dr. Russell Jaffe, Fellow, Health Studies Collegium. Reprints available from ELISAIACT Biotechnologies. 14 Pidgeon Hill, #300, Sterling,VA 20 165. Sources include USDA food data base (Rev 9 & 10), Food & Nutrition Encyclopedia; Nutrition Applied Personally by M.Walczak; Acid & Alkaline by H.Aihara. Food growth, transport, storage, processing, preparation, combination, & assimilation influence effect Intensity. Thanks to Hank Liers for his original work. (Rev 6/0 1]

Swine Flu: Does Nutritional Status Aid Immunity?

2009-05-03T17:37:00.005-05:00

Swine Flu: Does Nutritional Status Aid Immunity? By Neil E. Levin, CCN, DANLA A new health threat has arrived in our shrinking world: the swine flu. It is an organism for which there is no preventive vaccine; the commonly available flu vaccine does not include this strain, so offers no protection. Likewise, antibiotics target only bacterial strains so are useless to stop the viruses responsible for colds and flus. There are a couple of drugs (Tamiflu® and Relenza®) which are prescribed for those who have actually come down with the flu, and sometimes recommended for those who may come into contact with flu sufferers. However, they are expensive and typically work if you have one at home and take it at the first sign of illness. For example, the Tamiflu® website reports that, if taken within 48 hours of the first appearance of symptoms, adults may feel better about 1.5 days faster than patients who did not take it. When the avian flu (another Type A Influenza, the most common type) scare was around two or three years ago (remember SARS? Avian Flu? Bird Flu?), our family physician offered both my wife and me precautionary prescriptions of Tamiflu®, for which we would have had to pay about $200 out of pocket for a two person one-time supply. It wouldn’t be covered by insurance since we didn’t have an actual diagnosis of influenza. Besides that, there is a shortage and these drugs typically have a relatively short shelf life of only about a year. We respectfully declined the offer. While that is certainly an option for those who want to or need to pay to see a physician and get a prescription, and it may be covered by your insurance, it is not a practical option for most of us just wanting to improve our natural resistance to a known threat; and certainly not a cure. Besides, drugs have their own side effects (including shrinkage of the wallet) that should be noted by potential users. That’s precisely why they are controlled substances that are only available from medical professionals. What is the swine flu and what can we do to protect ourselves from it? According to Dr. Joe Bresee, Chief of the Epidemiology and Prevention Branch of the CDC (Centers for Disease Control and Prevention) Influenza Division, “Swine flu is a respiratory disease of pigs caused by Type A Influenza viruses. The symptoms of [swine] flu in people are similar to the symptoms of regular human flu and include fever, cough, sore throat, body aches, headache, chills and fatigue. Some people have reported diarrhea and [vomiting] associated with swine flu as well. There is no vaccine available right now to protect against swine flu. However, there are everyday actions that people can take to help prevent the spread of germs that cause respiratory illnesses like influenza. Take these everyday steps to protect your health. Cover your nose and mouth with a tissue when you cough or sneeze. Throw the tissue in the trash can after you use it. Wash your hands often with soap and water, especially after you cough or sneeze. Alcohol-based hand cleaners are also effective. Try to avoid contact with sick people.” Well, that is helpful, but only to a point. Also seemingly important is the fact that Americans who have come down with swine flu to date have had only one death - compared to well over a hundred Mexican deaths - and seem to have had contracted a much milder form of the illness than our unfortunate neighbors to the south. I speculate that the American diet, despite its known shortcomings, may in some ways still be superior in its content of some important nutrients to the average diet of many Mexican citizens, and perhaps support a better immune response. At the time of this writing though, only 20 of the 140 Mexican deaths attributed to pneumonia-like symptoms have actually been confirmed as the swine flu. No doubt new information will be coming in daily. But there are reportedly an estimated 36,000 deaths from the common flu every year, mostly the very old and the very young. After reviewing a number of scientific papers to assess the potential of foods and food supplements to improve our bodies’ natural response to the flu, there are a number of things that you and your physician may want to consider. In the battle to maintain healthy respiratory function and properly modulate immune response, natural nutritional substances can be helpful. Various vitamins, minerals, herbs and amino acids support optimal immune function and respiratory health. In fact, there is evidence that nutrient status of the host even affects the genetic expression of viruses; that is, an unsuitable environment (the well-nourished body) inhibits the ability of the virus to freely replicate and thrive. This is not a list of cures; it is a list of natural substances that have shown promise in improving survival or resistance to influenza as recorded in published studies. Those who want to support their immune system should investigate these with the knowledge and consent of your physician; physicians may want to note these natural products that may support the nutritional status of your patients. · AHCC In a recent study, supplementation with AHCC resulted in a dose-dependent increase in survival in mice in response to acute influenza infection (influenza A virus: avian flu, H1N1, PR8). · Andrographis paniculata has been shown in studies to support a healthy and balanced immune response by modulating the immune system’s production of immune cells (Interferon gamma (IFNg), Interleukin-2 (IL-2), and T-cells). Numerous clinical studies have demonstrated its ability to significantly increase cell-mediated immunity in response to stresses, such as those encountered during seasonal changes. · Astragalus (Astragalus membranaceous) is an Oriental herb well known for aiding the immune system. Astragalus has been shown in non-clinical studies to support a number of aspects of healthy immune function, including the enhancement of T-Cell and Natural Killer (NK) cell activity. Natural killer cells destroy unhealthy cells in the body virtually on contact. · Black Elderberry (Sambucus nigra) standardized extract may provide protection against oxidative stress and modulate inflammatory cytokines to protect respiratory function. Elderberry provides Vitamins A and C, as well as anthocyanins, which are potent free radical scavengers. Clinical and non-clinical studies have demonstrated Elderberry's immune-supporting properties. One article reported that, “Constituents of European elderberry neutralize the hemagglutinin spikes found on the surface of viruses, including flu viruses, preventing the viruses from piercing cell walls and replicating. European elderberry extracts also enhance immune function by increasing cytokine production.” It also reported that two randomized, double-blind, placebo-controlled clinical trials have shown that a European elderberry preparation “can inhibit influenza A and B viruses when given to patients within 48 hours of symptom development”. · Echinacea (Echinacea purpurea and Echinacea angustifolia) is well known for its immune modulating effects. E. purpurea extracts demonstrate significant immunomodulatory activities. “Among the many pharmacological properties reported, macrophage activation has been demonstrated most convincingly.” E. purpurea has been shown to have antiviral effects, with most studies looking at either rhinoviruses (colds) or herpes simplex virus type-1 (HSV-1). Its polysaccharides were able to exert an antiviral action on the development of HSV-1 disease when supplied prior to infection. Reductions in numbers of upper respiratory infections have been noted in several trials, but generally the differences in the large variety of commercial and non-commercial products studied have resulted in conflicting reports. However, a meta-analysis of previously published studies was published in the British medical journal The Lancet Infectious Diseases and concluded, “Published evidence supports echinacea’s benefit in decreasing the incidence and duration of the common cold.” · Garlic (Allium sativum) compounds have been shown to have some antiviral effects. For example, a compound called allitridin (diallyl trisulfide) has anti-human herpes virus (HCMV) activity via a mechanism associated with suppression of the virus’ gene expression. Other important and better known compounds include allicin and ajoene. Allicin has been shown to reduce the incidence of colds and flus. “Among the viruses which are sensitive to garlic extracts are the human cytomegalovirus, influenza B, herpes simplex virus type 1, herpes simplex virus type 2, parainfluenza virus type 3, vaccinia virus, vesicular stomatitis virus, and human rhinovirus type 2. · Larch tree (Larix occidentalis) polysaccharides (arabinogalactans) help to support healthy intestinal flora and aid healthy immune function. “They stimulate the immune system through the activation of phagocytosis, competitive binding of bacterial fimbrae, and the potentiation of the reticuloendothelial system's effects.” · Resveratrol, naturally occurring in grape vines, grape skins and red wine, improves immune response and down-regulates the activation and production of proinflammatory cytokines. · Selenium has been shown to help the immune system modulate inflammatory response in mice challenged with reactive agents. Animals deficient in the mineral had much poorer outcomes than those whose diets were supplemented with this antioxidant mineral. · Vitamin C (ascorbic acid, ascorbate) in divided doses supports immunity. Taking about 500 mg at a time enhances absorption and avoids a laxative effect possible at higher doses. In a two-year long controlled study, “vitamin C administration resulted in an 85-percent decrease in cold and flu symptoms compared to the control group”. In a controlled trial of 226 patients with influenza A, where about half received 300 mg of vitamin C daily: “Pneumonia was reported in two cases in the treatment group and 10 in the control group, while hospital stays for influenza or related complications averaged nine days in the vitamin C group and 12 days in the control group.” · Vitamin D (cholecalciferol, ergocalciferol) deficiencies have been associated with immune challenges (such as the flu) during the winter months when sunlight is not as able to produce the vitamin in our bodies. A deficiency can inhibit the body’s ability to maintain health and immunity. · Vitamin E (alpha-tocopherol) deficiencies have been shown to decrease immune response and increase inflammatory responses leading to possible tissue damage in the respiratory system. · Zinc is recommended for immunity. Use up to 30 mg per day for this use; higher doses could increase the need for copper. These statements have not been evaluated by the FDA. The information provided by this article is intended for scientific and historical reference only and is not intended to diagnose, treat, prevent or cure any disease. If you have been exposed to or think you may have flu or any disease, see a physician as soon as possible. Do not try to self treat swine flu or any other disease; influenza can be life-threatening. Please inform your physician before taking any food supplements if you take any medications or have a known medical condition. Read all product labels carefully and follow all directions and label cautions, and do not exceed the highest recommended servings. Neil E. Levin, CCN, DANLA is a board certified clinical nutritionist with a Diplomate in Advanced Nutritional Laboratory Assessment. He is a professional member of the International & American Associations of Clinical Nutritionists and serves on the Scientific Council of the national Clinical Nutrition Certification Board. REFERENCES http://www.tamiflu.com/treat.aspx http://www.relenza.com/ http://foodasmedicine.blogspot.com/2009/04/dr-joe-bresee-swine-flu.html http://www.cdc.gov/h1n1flu/ http://www.cdc.gov/od/oc/media/pressrel/r030107.htm Cunningham-Rundles S, McNeeley DF, Moon A. Mechanisms of nutrient modulation of the immune response. J Allergy Clin Immunol. 2005 Jun;115(6):1119-28; quiz 1129. Review. Zaslaver M, Offer S, Kerem Z, Stark AH, Weller JI, Eliraz A, Madar Z. Natural compounds derived from foods modulate nitric oxide production and oxidative status in epithelial lung cells. J Agric Food Chem. 2005 Dec 28;53(26):9934-9. Calder PC, Kew S. The immune system: a target for functional foods? Br J Nutr. 2002 Nov;88 Suppl 2:S165-77. Janeway, Charles A.; Travers, Paul; Walport, Mark; Shlomchik, Mark (2001) Immunobiology, 5th Ed., Garland Publishing, New York and London. Beck MA, Handy J, Levander OA. Host nutritional status: the neglected virulence factor. Trends Microbiol. 2004 Sep;12(9):417-23. Review. PMID: 15337163 Nogusa S, Gerbino J, Ritz BW. Low-dose supplementation with active hexose correlated compound improves the immune response to acute influenza infection in C57BL/6 mice. Nutr Res. 2009 Feb;29(2):139-43. PMID: 19285605 Ritz BW, Nogusa S, Ackerman EA, Gardner EM. Supplementation with active hexose correlated compound increases the innate immune response of young mice to primary influenza infection. J Nutr. 2006 Nov;136(11):2868-73. PMID: 17056815 Ritz BW. Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. Nutr Rev. 2008 Sep;66(9):526-31. Review. PMID: 18752476 Hancke JL. PARACTIN® useful for the treatment of autoimmune diseases, and Alzheimer disease by activation of PPAR-Receptor. Instituto de Farmacologia, Universidad Austral de Chile, Valdivia Chile. Poolsup N, Suthisisang C, Prathanturarug S, Asawamekin A, Chanchareon U. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: systematic review of randomized controlled trials. J Clin Pharm Ther. 2004 Feb;29(1):37-45. Paractin® website: http://www.paractinpr.com/research.php McKenna DJ, Hughes K, Jones K (2002) Astragalus. Alt Ther 8(6):34-40. Lei H, Wang B, Li, W-P, Yang Y, Zhou A-W, Chen M-Z (2003) Anti-aging effect of astragalosides and its mechanism of action. Acta Pharmacol Sin 245(3):230-234. Youdim KA, Martin A, Joseph JA (2000). Incorporation of the elderberry anthocyanins by endothelial cells increases protection against oxidative stress. Free Radic Biol Med 29(1):51-60. Zakay-Rones A, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M 1995) Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med 1(4):361-369. Roxas M, Jurenka J. Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations Altern Med Rev. 2007;12(1):25-48. Zakay-Rones A, Thom E, Wollan T, Wadstein J (2004) Randomized study of the efficacy and safety of oral elderberry extract in the treatment of influenza A and B virus infections. J Int Med Res 32(2):132-140. Manganelli REU, Zaccaro L, Tomei PE (2005) Antiviral activity in vitro of Urtica dioica L., Parietaria Diffusa M. et K. and Sambucus nigra L. J Ethnopharmacol 98(3):323-327. Barak V, Halperin T, Kalickman I (2001) The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 12(2):290-6. Barrett B. Medicinal properties of Echinacea: a critical review. Phytomedicine. 2003 Jan;10(1):66-86. Review. PMID: 12622467 Schoop R, Klein P, Suter A, Johnston SL. Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Clin Ther. 2006 Feb;28(2):174-83. Review. Saunders PR, Smith F, Schusky RW. Echinacea purpurea L. in children: safety, tolerability, compliance, and clinical effectiveness in upper respiratory tract infections. Can J Physiol Pharmacol. 2007 Nov;85(11):1195-9. PMID: 18066121 Senchina DS, McCann DA, Flinn GN, Wu L, Zhai Z, Cunnick JE, Wurtele ES, Kohut ML. Echinacea tennesseensis ethanol tinctures harbor cytokine- and proliferation-enhancing capacities. Cytokine. 2009 Mar 13. [Epub ahead of print] PMID: 19286391 Ghaemi A, Soleimanjahi H, Gill P, Arefian E, Soudi S, Hassan Z. Echinacea purpurea Polysaccharide Reduces the Latency Rate in Herpes Simplex Virus Type-1 Infections. Intervirology. 2009 Apr 17;52(1):29-34. [Epub ahead of print] PMID: 19372701 Binns SE, Hudson J, Merali S, Arnason JT. Antiviral activity of characterized extracts from echinacea spp. (Heliantheae: Asteraceae) against herpes simplex virus (HSV-I). Planta Med. 2002 Sep;68(9):780-3. PMID: 12357386 Shah SA, Sander S, White CM, Rinaldi M, Coleman CI. Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. Lancet Infect Dis. 2007 Jul;7(7):473-80. Review. Erratum in: Lancet Infect Dis. 2007 Sep;7(9):580. PMID: 17597571 Zhen H, Fang F, Ye DY, Shu SN, Zhou YF, Dong YS, Nie XC, Li G. Experimental study on the action of allitridin against human cytomegalovirus in vitro: Inhibitory effects on immediate-early genes. Antiviral Res. 2006 Oct;72(1):68-74. Epub 2006 Apr 27. PMID: 16844239 Ankri S, Mirelman D. Antimicrobial properties of allicin from garlic. Microbes Infect. 1999 Feb;1(2):125-9. Review. PMID: 10594976 Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. 2001 Jul-Aug;18(4):189-93. PMID: 11697022 Choi EM, Kim AJ, Kim YO, Hwang JK. Immunomodulating activity of arabinogalactan and fucoidan in vitro. J Med Food. 2005 Winter;8(4):446-53. Currier NL, Lejtenyi D, Miller SC Effect over time of in-vivo administration of the polysaccharide arabinogalactan on immune and hemopoietic cell lineages in murine spleen and bone marrow. Phytomedicine. 2003 Mar;10(2-3):145-53. Friel H, Lederman H. A nutritional supplement formula for influenza A (H5N1) infection in humans. Med Hypotheses. 2006;67(3):578-87. Epub 2006 Apr 18. PMID: 16624496 Beck MA. Selenium and vitamin E status: impact on viral pathogenicity. J Nutr. 2007 May;137(5):1338-40. Review. PMID: 17449602 Beck MA. Antioxidants and viral infections: host immune response and viral pathogenicity. J Am Coll Nutr. 2001 Oct;20(5 Suppl):384S-388S; discussion 396S-397S. Review. PMID: 11603647 Friel H, Lederman H. A nutritional supplement formula for influenza A (H5N1) infection in humans. Med Hypotheses. 2006;67(3):578-87. Epub 2006 Apr 18. PMID: 16624496 Nandi BK, Subramanian N, Majumder AK, Chatterjee IB. Effect of ascorbic acid on detoxification of histamine under stress conditions. Biochem Pharmacol. 1974 Feb 1;23(3):643-7. Johnston CS. The antihistamine action of ascorbic acid. Subcell Biochem. 1996;25:189-213. Johnston CS, Martin LJ, Cai X. Antihistamine effect of supplemental ascorbic acid and neutrophil chemotaxis. J Am Coll Nutr. 1992 Apr;11(2):172-6. Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85-94. Carcamo JM, Pedraza A, Borquez-Ojeda O, Golde DW. Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation. Biochemistry. 2002 Oct 29;41(43):12995-3002. Kimbarowski JA, Mokrow NJ. Colored precipitation reaction of the urine according to Kimbarowski (FARK) as an index of the effect of ascorbic acid during treatment of viral influenza. Dtsch Gesundheitsw. 1967;22:2413-2418. [Article in German] Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev. 2008 Mar;13(1):6-20. Review. PMID: 18377099 Cannell JJ, Zasloff M, Garland CF, Scragg R, Giovannucci E. On the epidemiology of influenza. Virol J. 2008 Feb 25;5:29. Review. PMID: 18298852 Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E. Epidemic influenza and vitamin D. Epidemiol Infect. 2006 Dec;134(6):1129-40. Epub 2006 Sep 7. Review. PMID: 16959053 Beck MA. Selenium and vitamin E status: impact on viral pathogenicity. J Nutr. 2007 May;137(5):1338-40. Review. PMID: 17449602 Friel H, Lederman H. A nutritional supplement formula for influenza A (H5N1) infection in humans. Med Hypotheses. 2006;67(3):578-87. Epub 2006 Apr 18. PMID: 16624496 Arroll B. Non-antibiotic treatments for upper-respiratory tract infections (common cold). Respir Med. 2005 Dec;99(12):1477-84. PMID: 16291073

Folic Acid: Risks or Myths?

2009-04-20T22:04:00.004-05:00

There are theoretical risks for isolated folic acid in high doses. But these supposed risks fly in the face of established science and are controversial, not at all conclusive. There is also confusion over the significance of the supposed risks of high dose isolated folic acid in test tube and animal studies which do not identify a danger for moderate level supplementation - or even higher dose supplementation if combined with multivitamins or vitamin B-12. In other words, if the theoretical risks do not reflect real world human activities and the way that people actually obtain essential vitamins from their diet, including supplementation, aren’t these improbable risks really irrelevant to us? On the other hand, these negative reports may stop people from taking essential vitamins in quite reasonable amounts even though they are known to promote human health. Published human clinical science has determined that folic acid can reduce birth defects and has been proven to do so. Clinical science has also found mechanisms by which folic acid can prevent cancers, as well as the theoretical possibility that very high doses given in isolation can stimulate colorectal cancers including prostate cancer. There is stronger evidence that taking B-12 or a multivitamin along with high folic acid actually reduces rates of prostate and colon cancers. For example, in one human clinical trial where food intake, blood and plasma levels of folic acid were considered, Multivitamin users had about 2/3 the risk of subsequent prostate cancer as Non-Multivitamin users; only the independent use of folic acid was considered a risk factor. The report concluded, “…on the whole, the biological and epidemiological evidence supports the potential for folate supplementation to prevent colorectal neoplasia in humans.” (Cole) This shows that single nutrient studies, especially if unpublished and not peer reviewed or subjected to subsequent comments by experts in the field, should not be given overinflated importance when they are merely preliminary studies that may conflict with more relevant published human clinical studies. In the case of such conflicts, the human clinicals should bear more weight and be seen as more convincing, especially those that mimic the full range of variables (nutrients) in the human diet. Folic acid itself is considered non-toxic. Also, “data from in vitro and in vivo studies indicate that folic acid is not genotoxic [damaging to genetic material]”. (UK Food Standards Agency) There have been reports of levels as high as 50,000 micrograms per day given with no signs of toxicity in humans. There are accepted problems associated with levels exceeding 5,000 micrograms a day, which resulted in a far more conservative Upper Limit of 1,000 micrograms daily being set. This effect has been demonstrated in patients suffering from pernicious anemia taken off of their successful medicine (vitamin B-12), which was replaced by 5,000 mcg/day of folic acid. The substitution of one vitamin for another was unsuccessful in treating pernicious anemia, but did mask some symptoms. This test – and a large safety margin - provided the rationale given for the current Upper Limit. But it does not logically imply danger to those who are not severely anemic and who obtain B-12 in adequate amounts. (Oakley) It is very uncommon for people to take folic acid singly in doses of thousands of micrograms daily, but this is the method which test tube and animal studies often use. Overemphasizing unproven cancer risks requires ignoring valid studies showing reductions of cancers by taking folic acid and multivitamins. Needlessly scaring people from taking their vitamins, which have in human clinical trials shown significant improvements in birth defect and cancer rates, is not helpful to our common goal of protecting public health. Neil E. Levin, CCN, DANLA QUOTES & REFERENCES: Dr. Gideon Koren, director of the Motherisk Program at the Hospital for Sick Children in Toronto , note that rates of birth defects such as spina bifida and cancers such as neuroblastoma have plummeted since folic acid supplementation was begun. He believes that the known benefits outweigh theoretical risks. "I think it is very important to remember that the scares about cancer are mostly from animal studies and laboratory studies, not from human experience," he says. "We are still awaiting to see such human experience." http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20090417/folic_acid_090418/20090419?hub=SciTech Health Canada recommends all women of childbearing age take 0.4 mg of folic acid a day, but says taking more than 1 mg a day of folic acid without the advice of a doctor is not recommended. "We continue to encourage all women who could become pregnant to take a daily supplement," the agency says on its website. "We caution against taking more than one multivitamin tablet a day, as excess amounts of certain vitamins can be toxic." http://www.ctv.ca/servlet/ArticleNews/story/CTVNews/20090417/folic_acid_090418/20090419?hub=SciTech “All women who could become pregnant should take a multivitamin containing 0.4 mg of Folic Acid every day. To help reduce the risk of NTDs, you should start taking the vitamin supplement at least three months before you get pregnant and continue through the first three months of your pregnancy. Talk to your health professional to find the supplement best for you…If you have had a previous pregnancy affected by an NTD or have a family history of this problem, see your doctor. You may be advised to take a higher dosage of Folic Acid. If you have diabetes, obesity or epilepsy, you may be at higher risk of having a baby with an NTD, and you should see your doctor before planning pregnancy… Do not take more than one daily dose of vitamin supplement as indicated on the product label. Increasing your dose of Folic Acid beyond 1 mg per day without the advice of a doctor is not recommended.” (Public Health Agency of Canada , 2/27/08; http://www.phac-aspc.gc.ca/fa-af/index-eng.php) The NIH’s Office of Dietary Supplement reports on the prevention of cancer with the use of supplemental folic acid as part of a multivitamin: “Over 88,000 women enrolled in the Nurses' Health Study who were free of cancer in 1980 were followed from 1980 through 1994. Researchers found that women ages 55 to 69 years in this study who took multivitamins containing folic acid for more than 15 years had a markedly lower risk of developing colon cancer.” (Giovannucci E, et al. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann Intern Med 1998;129:517-24; http://ods.od.nih.gov/factsheets/folate.asp) Cole BF, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. Polyp Prevention Study Group. JAMA. 2007 Jun 6;297(21):2351-9. PMID: 17551129 Figueiredo JC, et al. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst. 2009 Mar 18;101(6):432-5. Epub 2009 Mar 10. PMID: 19276452 Folic Acid, CASRN: 59-30-3. NLM TOXNET Hazardous Substances Database accessed online 28 March, 2009. http://toxnet.nlm.nih.gov/cgi-bin/sis/search/r?dbs+hsdb:@term+@na+folic+acid Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, McQueen MJ, Probstfield J, Fodor G, Held C, Genest J Jr; Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. N Engl J Med. 2006 Apr 13;354(15):1567-77. Epub 2006 Mar 12. Erratum in: N Engl J Med. 2006 Aug 17;355(7):746. PMID: 16531613 Oakley GP Jr. When will we eliminate folic acid-preventable spina bifida? Epidemiology. 2007 May;18(3):367-8. PMID: 17435446 http://www.food.gov.uk/multimedia/pdfs/evm_folicacid.pdf

Behind the Mirror

2009-04-15T12:04:00.002-05:00

"Pay no attention to the drugs behind the mirror." What some physicians do in excusing drug side effects while pointing fingers at dietary supplements; with apologies to the Wizard of Oz.

To Age is Human, To Mature Divine

2009-04-13T08:55:00.005-05:00

To Age is Human, To Mature Divine a new phrase, coined today, 4/13/2009 by Neil E. Levin

Gluten issues, allergies vs sensitivities vs digestive issues

2009-02-21T15:09:00.004-06:00

All grains contain gluten; some forms are just more allergenic or more difficult to process than others, which can vary from individual to individual. Wheat is the most common gluten reaction; which is also possible for rye, oats, barley and buckwheat. Some people are sensitive to certain proteins because of leaky gut, a condition where digestion is impaired because of GI tract disorders. Non-allergenic "delayed sensitivity reactions" to proteins may be caused by leaky gut and the specific immune cells reacting to these specific proteins can be reprogrammed to be non-reactive to them by completely avoiding these specific foods for at least 6 weeks. Not so for true food allergies, which can be permanent and trigger ever-increasing reactions with every occasional exposure. People's abilities to digest proteins vary with genetics, immune system capacity and probiotics present in the gut. There is even current research on specific bacteria that prevent the damage caused by wheat in susceptible people's guts. Only about 1% of the population tests as truly allergic to wheat protein, between 1-2% for dairy protein. Obviously, many more are (temporarily) sensitive to these proteins based on gut dysbiosis and leaky gut tissues failing to completely digest these foods. The issue of lactose intolerance is another possible cause of gas or bloating after consuming non-fermented dairy products (except for low-lactose products like whey protein isolate). The use of antacids is a major factor reducing digestion of proteins and minerals in the stomach, as well as reducing the essential acidic barrier against pathogenic organisms that may be present in our food and water; even from dirty hands that we use to eat. Stress and improper chewing may also contribute to the presence of extra undigested proteins in the gut, composed of undigested food and undesirable microbes. Who's left to clean up the mess and try to get some badly needed nutrients into the bloodstream? The immune system, though imperfectly. A major part of immune cell counts and activity is in the GI tract for exactly this reason, consuming a lot of energy. If digestion fails and the GI tract contains an unhealthy mixture of organisms and large protein masses, the result is a significant immune challenge by every measure, leading to inflammation and fatigue. Glutamine is an amino acid present in most protein-containing foods that is essential to brain and nerve function. Magnesium, other amino acids (ie taurine) and antioxidant co-factors render it far less overexciting to neurons. MSG and aspartame are additional proteins that can cause nerve overstimulus in some circumstances. There are ways to reduce these reactions, as described thoroughly by Dr. Russell Blailock in his books, lectures and articles. The bottom line: No need for most people to avoid soy, milk or grains if they can maintain the intregrity of their digestive and GI tracts properly. Most of those whose systems aren't in such good health can utilize fairly effective means of correcting these issues and eventually resuming the use of these foods in their diets, unless they are the relatively few with true allergies.

Price Lookup Codes Identify Organic and Genetically Engineered Produce

2009-02-21T14:43:00.004-06:00

The International Federation for Produce Coding (IFPC) creates Price-Look Up (PLU) codes for fresh fruits and vegetables. These four-digit codes are put on stickers and applied to the produce items. Organic and genetically engineered produce are identified by a fifth PLU digit on the sticker. You can identify organic items by the number "9" leading the five-digit PLU, and you can identify genetically engineered items by the number "8" leading a five-digit PLU number. Both of these categories will have five digits instead of the standard four. The four-digit code remains the same even if a fifth digit (8 or 9) is added. In the following example, conventional bananas have a standard PLU code of 4011. Organic bananas are coded 94011 and genetically engineered bananas are coded 84011. For me, the 9 prefix (for organic produce) is desirable and the 8 (for genetically engineered) is not. I use this rhyme to remind myself of the difference: “I hate eight, but nine is fine.” For more information about PLU codes, visit www.plucodes.com/plucodesfaq.asp

Stress and Sleep, melatonin and cortisol

2009-02-21T14:05:00.002-06:00

Sleep allows an overactive adrenal to rest overnight, also allowing your melatonin to give you a good night's sleep. Cortisol and melatonin are agonists, and fight for dominance. Cortisol is a stress hormone made by the adrenal gland and melatonin is an antioxidant sleep hormone produced by the pineal gland at night, in darkness. Normally melatonin takes over the night, slowing down cortisol production in the adrenal gland and encouraging proper rest and repair cycles. Then it wanes and cortisol and other adrenal hormones take over during the day, giving you energy. They should switch off in a normal daily cycle. If the adrenal won't shut down properly overnight due to stress, one may have inadequate melatonin resulting in an improper rest and repair cycle wearing you down. High cortisol levels are also associated with encouraging the depositing of fat in the abdomen, specifically. So reducing cortisol may also inhibit the formation of abdominal fat.

testing dietary supplements

2009-02-21T13:46:00.002-06:00

My experience with dietary supplements is that analysis of products with multiple ingredients, especially those at low concentrations, is very difficult and requires experience with the particular supplement matrix (formula plus excipients). Random testing of products off the shelf is fraught with technical difficulties. In addition, many ingredients lack standard, universally accepted testing methods within a dietary supplement matrix, which can result in confusion. These are sophisticated issues, whose resolution sometimes is difficult for anyone trying to ascertain product quality based on limited testing and lack of relevant experience. That is why most labs prefer to test single ingredient products, a tacit admission of the uncertainties involved in testing complex formulations. Testing is not as black and white as news releases often indicate or imply. Further, extrapolation of analytical results to nutrition, health and safety issues also requires expertise in these sometimes controversial areas, which very few labs have. It is important to verify label claims, but sometimes the manufacturer's validated procedures for qualification of an individual ingredient - combined with appropriate quality controls to assure that a proper mixture has been made - may more accurately represent the quality and quantity of that ingredient in a formula than any lab results obtained by applying a single analytical test to vastly different formulations containing that ingredient.