Showing posts with label cortisol. Show all posts
Showing posts with label cortisol. Show all posts

Tuesday, March 22, 2011

Sleep-Stress Interview, Natural Products Marketplace magazine

Everyone living in our modern world experiences stress, and if our ability to adequately control it diminishes so does our ability to get a good night’s sleep. Sleep time allows repair and recovery to occur, both mental and physical. The inability to recover from chronic stress can increase stress-related eating habits with a subsequent accumulation of abdominal fat on the one hand, and lead to physical and emotional exhaustion on the other. In fact, the deprivation of sound sleep is a common complaint that is associated with a lack of energy. Energy deficits can lead to a diminished immune response. So we see a host of common complaints that can be at least partially attributed to a lack of sleep and the causes thereof.

The lack of a good night’s sleep can be related to a lack of melatonin; a natural hormone made from the amino acid l-tryptophan and its metabolite 5-HTP. Melatonin is formed from serotonin, a metabolite of 5-HTP that is made in the pineal gland during darkness…this means that falling asleep in a bright room, or in front of the TV, may leave one less than fully engaged in sleep and its several stages of healthy brain waves that allow true relaxation to occur. Melatonin is also an antagonist of the aforementioned stress hormone cortisol, and so adequate darkness/sleep/melatonin production is a key factor in controlling chronic stress and its negative effects on the body.

The adrenal glands help the body respond and adjust to stress generated from both internal and external forces. Under chronic stress, cortisol can be overproduced, resulting in weight gain and difficulty in managing healthy blood sugar levels. Adaptogenic herbs help the body to manage the negative effects of stress, such as excess abdominal fat deposition, overeating, and low energy levels.

We see specific sleep solutions that are targeted to enhance certain normal mechanisms; for example, to reduce cortisol and/or increase melatonin to maintain them within healthy levels. Another strategy is to add certain amino acids that are precursors of relaxing or inhibitory neurotransmitters. And some people prefer to utilize individual herbs, while others prefer to take a formula combining multiple mechanisms.

Kava Kava helps people to relax but does not act as a strong sedative. Kava has been used by people to stay calm before taking a test and may support mental focus and calmness.

The essential mineral Magnesium has long been used, sometimes with Calcium, to relax muscles. Magnesium also has an effect to relax overstimulated brain neurons by acting against those excitotoxic states.

L-Theanine is an amino acid found commonly in green tea. L-Theanine promotes relaxation without the drowsiness or negative side effects associated with some other calming agents. L-Theanine also supports healthy cardiovascular function through this relaxing effect, as well as its antioxidant properties.

L-Tryptophan and 5-HTP products are available in various strengths; make sure that the one you buy has been safety, identity, and potency tested. These amino acids are precursors of the important neurotransmitter serotonin, as well as its metabolite melatonin. Melatonin is used by the body to regulate sleep cycles, as an antioxidant, and as an anti-stress aid; in addition to other wide-ranging health effects on the human body.

Relora® is an all-natural proprietary blend of plant extracts from Magnolia officinalis and Phellodendron amurense herbs that helps to control cortisol. Relora® is a safe, non-sedating formula that can help to alleviate symptoms associated with stress such as nervous tension, irritability, concentration difficulties and occasional sleeplessness. The relaxing effect of Relora® can thereby help to control appetite and prevent stress-related eating, aiding in weight control.

100% pure Essential Oils have long been used for aromatherapy, including some oils known to be relaxing. Whether using these oils to sniff, use with reed or other diffusers, blending into carrier oils (almond, olive, apricot kernel, etc.) for massage, or adding a few drops to bath water or potpourri, many people find some of these powerful oils to be very relaxing. Lavender, Chamomile, Marjoram, and Germanium Oils are especially soothing and relaxing.

Some supplements are safe to take daily; for example, the gentler stress vitamins, Chamomile tea, essential oils used in aromatherapy. It is best to be more cautious with stronger herbal and amino formulas, though there’s no strict rule of thumb on how long to take them. Chronic stress may need to be dealt with for many months, resisting a quick fix. On the other hand, one can often cut the melatonin dose down after a month or two of resetting the sleep cycle.

People may not sleep due to a number of factors, and their individual stressors makes it more difficult to figure out which products may help them to normalize their sleep and minimize their stress. Matching the person to the solution is always the biggest challenge, and some trial and error may need to be factored in before a solution is found.

For some products, like melatonin, chewables and liquids may be popular. For herbal formulas, capsules and liquids dominate, but we find that the chewables and capsules sell best for melatonin. Aminos tend to be in powders, chewables, and capsules, with the occasional tablet form.

Sometimes obvious things like limiting caffeine, setting nighttime winding down rituals, and creating a calm space for sleep can be helpful.

Saturday, February 21, 2009

Stress and Sleep, melatonin and cortisol

Sleep allows an overactive adrenal to rest overnight, also allowing your melatonin to give you a good night's sleep. Cortisol and melatonin are agonists, and fight for dominance. Cortisol is a stress hormone made by the adrenal gland and melatonin is an antioxidant sleep hormone produced by the pineal gland at night, in darkness. Normally melatonin takes over the night, slowing down cortisol production in the adrenal gland and encouraging proper rest and repair cycles. Then it wanes and cortisol and other adrenal hormones take over during the day, giving you energy. They should switch off in a normal daily cycle. If the adrenal won't shut down properly overnight due to stress, one may have inadequate melatonin resulting in an improper rest and repair cycle wearing you down. High cortisol levels are also associated with encouraging the depositing of fat in the abdomen, specifically. So reducing cortisol may also inhibit the formation of abdominal fat.

Thursday, June 28, 2007

My review of studies supporting the use of aromatherapy to reduce symptoms of aging

http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD003150/frame.html Aroma therapy is the use of pure essential oils from fragrant plants (such as Peppermint, Sweet Marjoram, and Rose) to help relieve health problems and improve the quality of life in general. The healing properties of aroma therapy are claimed to include promotion of relaxation and sleep, relief of pain, and reduction of depressive symptoms. Hence, aroma therapy has been used to reduce disturbed behaviour, to promote sleep and to stimulate motivational behaviour of people with dementia. Of the three randomized controlled trials found only one had useable data. The analysis of this one trial showed a significant effect in favour of aroma therapy on measures of agitation and neuropsychiatric symptoms. More large-scale randomized controlled trials are needed before firm conclusions can be reached about the effectiveness of aroma therapy. Aroma therapy for dementia. Cochrane Database Syst Rev. 2003;(3):CD003150. Review. PMID: 12917949 http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=9672344&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus RESULTS: Eight randomized, controlled trials were located. Collectively they indicate that peppermint oil could be efficacious for symptom relief in IBS. A metaanalysis of five placebo-controlled, double blind trials seems to support this notion. In view of the methodological flaws associated with most studies, no definitive judgment about efficacy can be given. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol. 1998 Jul;93(7):1131-5. PMID: 9672344 In aromatherapy, grapefruit is used to treat depression and induce euphoria, whereas lavender is beneficial in reducing stress and relaxing the mind. This raises the possibility that stimulation with grapefruit or lavender may influence the activity of sympathetic nerves. Mechanism of changes induced in plasma glycerol by scent stimulation with grapefruit and lavender essential oils. Neuroscience Letters, Volume 416, Issue 3, 18 April 2007, Pages 241-246 The antimicrobial and antioxidant properties of essential oils have been known for a long time, and a number of investigations have been conducted into their antimicrobial activities using various bacteria, viruses and fungi. A common feature of plant volatiles is their hydrophobic nature, and studies addressing the mode of antimicrobial action of such compounds generally point to the cell membrane as primary target (Stammati et al., 1999). Recent studies have shown that essential oils of oregano, thyme, clove and cinnamon are among the most active in this respect. Chemical analysis of these oils has shown the constituents to be principally carvacrol, thymol and eugenol and their precursors...Essential oils—their antimicrobial activity against Escherichia coli and effect on intestinal cell viability. Toxicology in Vitro, Volume 20, Issue 8, December 2006, Pages 1435-1445 Symptoms of tiredness, lack of muscle co-ordination and dysarthria, and difficulty in maintaining attention in elderly people may be wrongly labelled as part of the ageing process and so ignored. If adequate sleep can reduce these symptoms and restore therapeutic activity, it is of enormous value to elderly people in retaining their independence and quality of life. Safe promotion of sleep without daytime lethargy is needed. In order to test the hypotheses that Essential Oil of Lavender has a sedative effect, and that the resultant sleep promotes therapeutic activity, a pilot study was arranged with acutely ill elderly people. This was followed by a more detailed trial with long-term patients. The results show a positive trend towards improvement with lavender. The value of lavender for rest and activity in the elderly patient. Complementary Therapies in Medicine. Volume 4, Issue 1, January 1996, Pages 52-57 These findings clarify that lavender and rosemary enhance FRSA [free radical scavenging activity] and decrease the stress hormone, cortisol, which protects the body from oxidative stress. Smelling lavender and rosemary increases free radical scavenging activity and decreases cortisol level in saliva. Psychiatry Research Volume 150, Issue 1, 28 February 2007, Pages 89-96 A general feature of these various antioxidant parameters measured was that their activities remained higher in rats whose diets were supplemented with thyme oil, suggesting that they retained a more favourable antioxidant capacity during their life span. Dietary supplementation of thyme (Thymus vulgaris L.) essential oil during the lifetime of the rat: its effects on the antioxidant status in liver, kidney and heart tissues. Mechanisms of Ageing and Development. Volume 109, Issue 3, 8 September 1999, Pages 163-175 Symptoms of tiredness, lack of muscle co-ordination and dysarthria, and difficulty in maintaining attention in elderly people may be wrongly labelled as part of the ageing process and so ignored. If adequate sleep can reduce these symptoms and restore therapeutic activity, it is of enormous value to elderly people in retaining their independence and quality of life. Safe promotion of sleep without daytime lethargy is needed. In order to test the hypotheses that Essential Oil of Lavender has a sedative effect, and that the resultant sleep promotes therapeutic activity, a pilot study was arranged with acutely ill elderly people. This was followed by a more detailed trial with long-term patients. The results show a positive trend towards improvement with lavender. The value of lavender for rest and activity in the elderly patient. Complementary Therapies in Medicine. Volume 4, Issue 1, January 1996, Pages 52-57 Aromatherapy can be a useful addition to self-care especially in managing stress and minor self-limiting conditions. Caring for the wounded healer—nurturing the self. Journal of Bodywork and Movement Therapies. Volume 10, Issue 4, October 2006, Pages 251-260 The goal of this study was to investigate the impact of the essential oils of orange and lavender on anxiety, mood, alertness and calmness in dental patients. Two hundred patients between the ages of 18 and 77 years (half women, half men) were assigned to one of four independent groups. While waiting for dental procedures patients were either stimulated with ambient odor of orange or ambient odor of lavender. These conditions were compared to a music condition and a control condition (no odor, no music). Anxiety, mood, alertness and calmness were assessed while patients waited for dental treatment. Statistical analyses revealed that compared to control condition both ambient odors of orange and lavender reduced anxiety and improved mood in patients waiting for dental treatment. These findings support the previous opinion that odors are capable of altering emotional states and may indicate that the use of odors is helpful in reducing anxiety in dental patients. Ambient odors of orange and lavender reduce anxiety and improve mood in a dental office. Physiology & Behavior. Volume 86, Issues 1-2, 15 September 2005, Pages 92-95 In this review we detail the current state of knowledge about the effect of lavender oils on psychological and physiological parameters and its use as an antimicrobial agent. Although the data are still inconclusive and often controversial, there does seem to be both scientific and clinical data that support the traditional uses of lavender. Biological activities of lavender essential oil. Phytother Res. 2002 Jun;16(4):301-8. Review. PMID: 12112282