What is Taurine and how is it made?

Taurine is a nature-identical/natural form amino acid that’s commercially synthesized from common chemicals. It’s made from the reaction of sulfuric acid with mono-ethanol amine; also known as ethanolamine; which is an amino alcohol that’s also part of phospholipids, like the phosphatidylethanolamine (PE) in lecithin, that are important components of cell membranes. 

Taurine, a sulphur-containing amino acid, is the most abundant intracellular amino acid in humans, and is involved in numerous biological and physiological functions, including bile production and heart health. Once we pass infancy, we routinely synthesize taurine in our bodies from the amino acids methionine and cysteine with the aid of vitamin B₆. That makes it a nonessential amino acid for most of us; though specific groups of individuals are at risk for taurine deficiency and may benefit from supplementation. 

I personally take 1,000 mg of taurine twice a day for heart heath now, as I have had troubling arrhythmia incidents send me to the emergency room and am medically at risk for progressively worse outcomes over time. It has shown effectiveness in increasing exercise capability in heart failure patients and arterial compliance to nitric oxide to support healthy blood pressure. I also take l-carnitine, olive leaf extract, magnesium, l-citrulline, Pycnogenol, grape seed extract, hawthorn leaf and flower extract, a good multivitamin, and other supplements to support my cardiovascular health and hold off that disturbing prognosis as long as possible. 

Taurine has no d- or l- forms, similar to glycine but unlike most amino acids that have different optical rotations in distinct natural and synthetic forms. All taurine is the natural form, even if produced by chemical synthesis, whether commercially or in our bodies. 

My Interview on Memory and Brain Health for a trade magazine

The brain must be intact and healthy in order for it to perform normal functions like thought and memory. There is evidence that chronic or acute inflammation, or other insults to brain cells/tissues from chemicals or other damaging agents, can provoke negative health effects. In essence, the brain is literally under attack on a daily basis, requiring a constant infusion of supporting protective nutrients to maintain proper brain health and functionality.

Antioxidants and magnesium are key nutrients needed to protect the brain from chemicals called excitotoxins, such as MSG, which are damaging to brain cells when levels of various nutrients are insufficient to control them. The physical damage to brain cells that can be caused by oxidation, sometimes in the form of a bio-electrical spark causing a chain reaction that rips electrons from a string of innocent cells until an antioxidant ‘electron donor’ puts an end to it, can be prevented or stopped by antioxidants. Antioxidants also protect fats from oxidizing (going rancid), and since the brain is nearly half fat it is dependent on both fatty acids and antioxidants to protect its structural integrity.

While it is normally not necessary to see a physician before taking a brain/memory support dietary supplement, people on medications should always check if there are known interactions before using any new supplement and it is wise to always bring a list of your supplements to share with your doctor at your annual check-up. Those with known memory problems should request a medical evaluation to set a baseline level in order to maintain their mental assets and be able to compare future mental performance.

To aid this preservation of our mental faculties, it is obviously best to consume adequate levels of relevant protective nutrients for many years, rather than waiting until the senility of old age creeps up on us and then trying to regain lost abilities. Otherwise, careful eating and appropriate supplementation may be started ‘too little, too late.’

The best mental/brain support nutrients include some surprisingly ordinary ingredients: Lecithin, Vitamins A-E, and Antioxidants. Lecithin provides essential phospholipids for the brain, nerves, and cell membranes; including Choline, Serine, and other brain nutrients that directly support neurotransmitter production and memory. Lecithin’s Phosphatidyl Choline (PC) is a precursor of the neurotransmitter acetylcholine; in the central nervous system acetylcholine is involved in learning, memory, and mood. Phosphatidylserine (PS) also affects the levels of neurotransmitters in the brain related to mood, memory, and mental function.

Lecithin, which is a highly processed extract of soybean oil, does not in itself contain protein (allergens) or genetic material (GMOs), which the original soybeans may have contained. Some Lecithin products are derived from certified non-GMO soybeans or even sunflower seeds.

Another way to get Lecithin’s benefits is in the form of Krill Oil. Krill has its Omega-3 fatty acids bonded to phospholipids similar to those found in soy or egg lecithin. So krill not only supplies EPA, DHA, and phospholipids for brain, nerve, and membrane health but also enhances their bioavailability and access to the brain due to the ability of phospholipids to cross the blood-brain barrier better than ordinary fish oils. Fish Oils providing EPA and DHA should also be considered brain nutrients, as DHA is a significant physical component of the brain.

Vitamin E and its related compounds (the tocotrienols) have been shown to protect neurons (brain and nerve cells) from being damaged or even killed off by excitotoxic chemicals. The antioxidant benefits of this essential vitamin’s “family” of compounds also help to prevent oxidative reactions that can damage brain tissues. Look for gamma-tocopherol along with the usual alpha-tocopherol plus higher amounts of gamma- and delta- form tocotrienols.

Vitamin C directly pumps excitotoxins from neurons, protecting the brain and nerve cells from being damaged by these potentially toxic chemicals. There are several populations with impaired ascorbate absorption; including those with poor insulin sensitivity, those with gut inflammation, those who take aspirin, and those on low sodium diets; all situations where normal vitamin C uptake and utilization is often suboptimal.

Other antioxidants of benefit for brain health include Alpha Lipoic Acid, various carotenoids including Astaxanthin (also found in Krill oil), and Pycnogenol®. In addition to supplementation, it always helps to consume a variety of antioxidants from fruits and vegetables to maintain a good level and balance of antioxidants.

The formation of abnormal structures in the brain may in part be due to oxidative damage that perhaps can be kept within normal acceptable ranges by having a variety of antioxidant nutrients available. Genes in the subject cells are controlled by “switches,” that are in turn modulated by environmental “triggers.” The presence of various protective nutrients helps to maintain proper cellular health; whereas the deficiency of adequate protective nutrients can allow potentially damaging effects, leading to cell death and the subsequent formation of abnormal brain structures.

The presence of excessive amounts of saturated fats in the diet, especially if from an excess of processed foods, inevitably reduces the amount of available long-chain fatty acids EPA and DHA (DHA can be made from EPA) that are essential for brain and nerve health. The deficit of these two fatty acids increases the likelihood of uncontrolled inflammatory processes in the body, as an imbalance of beneficial dietary fats like EPA, DHA and GLA that can reduce the fatty acids needed to make prostaglandins responsible for maintaining a healthy inflammatory response. The fact that EPA is needed for healthy membranes throughout the body and DHA is an important constituent of the brain itself also testify to the importance of these fatty acids for healthy brain structures and functions, including memory.

• Natural antioxidant vitamins Beta-Carotene, C, and E are protective of brain tissues and are available in antioxidant formulas and multiple vitamins..

• Alpha GPC is a form of choline that is bioavailable to the brain; an acetylcholine precursor, it supports memory and cognitive acuity.

• DMAE is a naturally occurring amino metabolite known primarily as a precursor to choline and acetylcholine, chemicals in the brain responsible for nerve transmissions and cognitive function; DMAE has been used most predominantly to improve memory and focus while stimulating neural activity.

• NADH is a metabolite of niacin (vitamin B3) that is directly involved in neurotransmitter production to support mental alertness.

• Ginkgo biloba extract is thought to improve memory and quality of life, and is available in various strengths.

• Acetyl-L-Carnitine is a form of an important amino acid, which in short-term studies has improved memory in older adults.

• Vitamin B1 deficiencies have been associated with confusion and memory loss in seniors deficient in that nutrient.

• High strength fish oils and Krill oil supply the omega-3 fatty acids DHA and EPA that are important brain and nerve components often deficient in the general population.

• Genistein, a phytoestrogen found in Soy Protein Isolates and Soy Isoflavones, has been shown to act as an antioxidant to preserve brain cell integrity.

• Ashwagandha has been shown to be protective of brain cells in non-clinical laboratory experiments.

Memory and Age

Memory and Age By Neil E. Levin, CCN, DANLA The most important things for an older person to consider in protecting against minor memory loss – often attributed to “aging” – include: · Maintain at least a nominal physical activity level to keep circulation and body functions at optimal levels. · Take a good multivitamin to assure minimal levels of essential nutrients. Too many elders fail to eat properly or to get adequate levels of B vitamins and other key nutrients associated with proper cognitive function. Also, the elderly don’t absorb nutrients from food as efficiently, making supplementation even more important. · Don’t forget to eat meals. Often, single, divorced or widowed seniors fail to eat regular meals on schedule. This creates nutrient deficiencies that complicate their ability to maintain physical and mental health. · Don’t overeat on processed, high fat, high sodium foods such as fast foods to “compensate” for poor eating habits. · Take foods and supplements that are rich in antioxidants. Oxidative damage is clearly associated with many of the conditions that affect mental, as well as physical, capabilities in older people. This includes negative changes to the brain itself; and also the nervous system, the eyes and joints. · Use vitamin D, which may be in your multivitamin or calcium supplement, to compensate for the lack of direct sunlight on skin. This essential vitamin also helps with immunity, cardiovascular health and bone health. · If your dietary habits are reasonably good and you still want some more natural aids for brain and memory function, consider a brain nutrient formula. Of course, college age is a time when many students want to use brain nutrients to maximize their learning and recall, especially for tests. Many adults then coast through adulthood until they reach their 40’s or 50’s and start to get a little forgetful. By then, they should already be examining their diet, lifestyle and stress levels to consider whether they may need additional nutritional support for their mental functions. If they wait until things get bad - in their 60’s, 70’s or later - it may be too late to preserve their memories and mental acuity. Basic brain nutrients are multivitamins, lecithin and fish oil. Antioxidants will protect the brain’s structures and functions throughout adulthood. Magnesium, an essential mineral that is deficient in 90% of Americans, helps to reduce toxic effects of chemicals on neurons; as do antioxidants such as vitamin E, tocotrienols, and vitamin C. People will usually hint at the need, or ask about Ginkgo or look at the section. We’re not the family, friends or work colleagues that people try to hide symptoms from…after all; we are the ones that perfect strangers often disclose their bowel habits and other normally hidden quirks to. Speaking in user-friendly but technical structure-function language will often make the discussion less personal and more scientific, removing much of the emotional content of the health issue. Phosphatidyl Serine is a phospolipid compound derived from soy lecithin that plays an essential role in cell membrane composition and intercellular communication. Phosphatidyl Serine is a major structural component of neural membranes where it assists in the conduction of electrical impulses and facilitates the activity of neurotransmitters involved in learning, memory and mood. These properties make Phosphatidyl Serine formulas ideal basic supplements for the support of cognitive function. There is enough evidence of the safety and efficacy of PS for the FDA to have issued a qualified health claim for it. DMAE is known primarily as a precursor to choline and acetylcholine (chemicals in the brain responsible for nerve transmissions and cognitive function), and has been used most predominantly to improve memory and focus while stimulating neural activity. Many researchers believe that it may serve an anti-aging function by increasing the body’s capacity to produce acetylcholine – a deficiency commonly associated with memory loss. Scientific research has demonstrated that Ginkgo Biloba Extract has antioxidant activity in in vitro studies and thus may aid in maintaining healthy brain and memory function. The insulating myelin sheaths that protect the brain, spine and thousands of miles of nerves in the human body are almost two-thirds Lecithin. Lecithin is composed of many different components, including Choline, Inositol, Linoleic Acid, Phosphatidyl serine, fatty acids and triglycerides. These valuable constituents of Lecithin are vital for the proper functioning of many metabolic processes. And let’s not forget the benefit of DHA and fish oil. Fish oils are typically molecularly distilled and tested to be free of screened for the absence of potentially harmful levels of contaminants (i.e. mercury, heavy metals, PCB's, dioxins, and other contaminants). DHA is utilized in forming the brain and nerves. And last but not least, antioxidants and magnesium are very helpful in protecting brain structures and may be useful in preventing some of the feared declines associated with aging brains. For example, vitamin C actually pumps glutamates out of neurons.